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Adlai Nortye (NASDAQ: ANL) has announced its plans to present preliminary data of AN0025 in combination with definitive chemoradiotherapy (dCRT) at the ASCO 2024 Annual Meeting in Chicago from May 31 to June 4, 2024. AN0025, a selective EP4 inhibitor, has shown antitumor activity by modulating macrophages and immunosuppressive myeloid cells. The study, AN0025S0104, is a single-arm, open-label, multicenter, Phase Ib trial, assessing the safety, tolerability, and feasibility of AN0025 plus dCRT for unresectable locally advanced or recurrent esophageal cancer (EC) and esophagogastric junction cancer. Previous studies highlighted the synergistic efficacy of AN0025 with CRT in rectal cancer. Adlai Nortye aims to address unmet patient needs through innovative oncology research.
Adlai Nortye announced the dosing of the first patient in its Phase II clinical trial, named ARTEMIS, for palupiprant (AN0025) in treating locally advanced rectal cancer. This study, led by the Cancer Research UK Clinical Trials Unit at the University of Leeds, aims to compare total neoadjuvant therapy (TNT) with or without AN0025 in patients with moderate to high-risk rectal cancer. The trial involves 140 patients, divided into two groups, and will evaluate clinical complete response (cCR) rate six months post-radiotherapy. The trial builds on encouraging Phase Ib results and seeks to improve efficacy while minimizing invasive surgeries.
