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Spero Therapeuti Financials

SPRO
Source SEC Filings (10-K/10-Q) Updated Sep 30, 2025 Currency USD FYE December
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This page shows Spero Therapeuti (SPRO) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 10 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Key Financial Metrics

Revenue
$48.0M
YoY-53.8%
5Y CAGR+21.5%

Spero Therapeuti generated $48.0M in revenue in fiscal year 2024. This represents a decrease of 53.8% from the prior year.

EBITDA
-$73.4M
YoY-435.8%

Spero Therapeuti's EBITDA was -$73.4M in fiscal year 2024, measuring earnings before interest, taxes, depreciation, and amortization. This represents a decrease of 435.8% from the prior year.

Free Cash Flow
N/A
Net Income
-$68.6M
YoY-400.6%

Spero Therapeuti reported -$68.6M in net income in fiscal year 2024. This represents a decrease of 400.6% from the prior year.

EPS (Diluted)
$-1.27
YoY-395.3%

Spero Therapeuti earned $-1.27 per diluted share (EPS) in fiscal year 2024. This represents a decrease of 395.3% from the prior year.

Cash & Debt
$52.9M
YoY-30.7%
5Y CAGR+12.2%

Spero Therapeuti held $52.9M in cash against $0 in long-term debt as of fiscal year 2024.

Dividends Per Share
N/A
Shares Outstanding
55M
YoY+3.0%
5Y CAGR+23.3%

Spero Therapeuti had 55M shares outstanding in fiscal year 2024. This represents an increase of 3.0% from the prior year.

Gross Margin
N/A
Operating Margin
-152.9%
YoY-173.6pp
5Y CAGR+195.5pp

Spero Therapeuti's operating margin was -152.9% in fiscal year 2024, reflecting core business profitability. This is down 173.6 percentage points from the prior year.

Net Margin
-142.9%
YoY-164.9pp
5Y CAGR+192.7pp

Spero Therapeuti's net profit margin was -142.9% in fiscal year 2024, showing the share of revenue converted to profit. This is down 164.9 percentage points from the prior year.

Return on Equity
N/A
R&D Spending
$96.8M
YoY+88.1%
5Y CAGR+8.0%

Spero Therapeuti invested $96.8M in research and development in fiscal year 2024. This represents an increase of 88.1% from the prior year.

Share Buybacks
N/A
Capital Expenditures
N/A

SPRO Income Statement

Metric Q3'25 Q2'25 Q1'25 Q3'25 Q3'25 Q2'25 Q1'25 Q4'24
Revenue $5.4M-61.6% $14.2M+141.6% $5.9M-61.0% $15.0M+11.7% $13.5M+32.1% $10.2M+10.0% $9.3M-87.4% $73.5M
Cost of Revenue N/A N/A N/A N/A N/A N/A N/A N/A
Gross Profit N/A N/A N/A N/A N/A N/A N/A N/A
R&D Expenses $8.6M-19.4% $10.7M-21.6% $13.6M-52.8% $28.8M+7.3% $26.9M+13.2% $23.7M+36.9% $17.3M+4.7% $16.6M
SG&A Expenses $4.2M-29.0% $5.9M-13.9% $6.8M-3.3% $7.1M+35.7% $5.2M-6.1% $5.5M-6.5% $5.9M-8.0% $6.4M
Operating Income -$7.9M-223.9% -$2.4M+83.4% -$14.7M+32.2% -$21.7M-16.8% -$18.6M+2.5% -$19.1M-36.3% -$14.0M-127.7% $50.5M
Interest Expense N/A N/A N/A N/A N/A N/A N/A N/A
Income Tax $0 N/A N/A N/A $290K N/A N/A N/A
Net Income -$7.4M-334.2% -$1.7M+87.7% -$13.9M+33.6% -$20.9M-21.8% -$17.1M+4.0% -$17.9M-41.0% -$12.7M-124.7% $51.2M
EPS (Diluted) $-0.13-333.3% $-0.03+88.0% $-0.25+34.2% $-0.38-18.8% $-0.32+3.0% $-0.33-37.5% $-0.24-124.7% $0.97

SPRO Balance Sheet

Metric Q3'25 Q2'25 Q1'25 Q3'25 Q3'25 Q2'25 Q1'25 Q4'24
Total Assets $54.2M-12.8% $62.1M-20.1% $77.7M-29.7% $110.5M-18.2% $135.2M-9.8% $149.9M-10.6% $167.7M-8.1% $182.4M
Current Assets $52.3M-11.9% $59.4M-20.5% $74.7M-30.4% $107.3M-18.5% $131.6M+7.7% $122.2M-12.8% $140.2M+6.8% $131.2M
Cash & Equivalents $48.6M+55.9% $31.2M-36.2% $48.9M-7.6% $52.9M-30.7% $76.3M+20.1% $63.5M-22.8% $82.3M+7.8% $76.3M
Inventory N/A N/A N/A N/A N/A N/A N/A N/A
Accounts Receivable N/A N/A N/A N/A N/A N/A N/A N/A
Goodwill N/A N/A N/A N/A N/A N/A N/A N/A
Total Liabilities $27.7M-5.5% $29.3M-33.3% $43.9M-31.9% $64.4M-7.5% $69.7M+0.4% $69.4M-2.9% $71.5M-5.4% $75.5M
Current Liabilities $13.6M-8.7% $14.9M-48.7% $29.2M-40.6% $49.1M0.0% $49.1M+7.6% $45.6M+9.1% $41.8M+12.6% $37.2M
Long-Term Debt N/A N/A N/A N/A N/A N/A N/A N/A
Total Equity $26.5M-19.3% $32.8M-2.9% $33.8M-26.7% $46.1M-29.6% $65.5M-18.6% $80.5M-16.4% $96.2M-10.0% $106.9M
Retained Earnings -$482.6M-1.6% -$475.2M-0.4% -$473.5M-3.0% -$459.6M-4.8% -$438.8M-4.1% -$421.6M-4.4% -$403.7M-3.2% -$391.1M

SPRO Cash Flow Statement

Metric Q3'25 Q2'25 Q1'25 Q3'25 Q3'25 Q2'25 Q1'25 Q4'24
Operating Cash Flow N/A N/A -$4.0M N/A N/A N/A $5.9M N/A
Capital Expenditures N/A N/A N/A N/A N/A N/A N/A N/A
Free Cash Flow N/A N/A N/A N/A N/A N/A N/A N/A
Investing Cash Flow N/A N/A N/A N/A N/A N/A N/A N/A
Financing Cash Flow N/A N/A N/A N/A N/A N/A N/A N/A
Dividends Paid N/A N/A N/A N/A N/A N/A N/A N/A
Share Buybacks N/A N/A N/A N/A N/A N/A N/A N/A

SPRO Financial Ratios

Metric Q3'25 Q2'25 Q1'25 Q3'25 Q3'25 Q2'25 Q1'25 Q4'24
Gross Margin N/A N/A N/A N/A N/A N/A N/A N/A
Operating Margin -145.5%-128.2pp -17.2%+233.6pp -250.8%-106.4pp -144.4%-6.4pp -138.0%+48.9pp -186.9%-36.1pp -150.9%-219.6pp 68.7%
Net Margin -135.7%-123.7pp -12.0%+224.1pp -236.1%-97.2pp -138.8%-11.5pp -127.3%+47.9pp -175.2%-38.5pp -136.7%-206.4pp 69.7%
Return on Equity N/A N/A N/A N/A N/A N/A N/A 47.9%
Return on Assets -13.6%-10.9pp -2.7%+15.1pp -17.8%+1.1pp -18.9%-6.2pp -12.7%-0.8pp -11.9%-4.4pp -7.5%-35.6pp 28.1%
Current Ratio 3.83-0.1 3.97+1.4 2.56+0.4 2.19-0.5 2.680.0 2.68-0.7 3.35-0.2 3.53
Debt-to-Equity 1.04+0.2 0.89-0.4 1.30-0.1 1.40+0.3 1.06+0.2 0.86+0.1 0.74+0.0 0.71
FCF Margin N/A N/A N/A N/A N/A N/A N/A N/A

Financial Health Signals

Profitability Growth Leverage Liquidity Cash Flow Returns 32 / 100
Financial Profile 32/100
Profitability
0
Growth
0
Leverage
59
Liquidity
67
Cash Flow
N/A
Returns
N/A

Based on FY2024 annual data. Scores normalized against common benchmarks.

Piotroski F-Score Weak
1/9

Financial strength trend (9 signals). 7-9 = strong, 0-3 = weak.

Earnings Quality Low Quality
0.34x

Operating cash flow vs net income. Above 1.0x = cash-backed earnings.

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Frequently Asked Questions

What is Spero Therapeuti's annual revenue?

Spero Therapeuti (SPRO) reported $48.0M in total revenue for fiscal year 2024. This represents a -53.8% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is Spero Therapeuti's revenue growing?

Spero Therapeuti (SPRO) revenue declined by 53.8% year-over-year, from $103.8M to $48.0M in fiscal year 2024.

Is Spero Therapeuti profitable?

No, Spero Therapeuti (SPRO) reported a net income of -$68.6M in fiscal year 2024, with a net profit margin of -142.9%.

What is Spero Therapeuti's earnings per share (EPS)?

Spero Therapeuti (SPRO) reported diluted earnings per share of $-1.27 for fiscal year 2024. This represents a -395.3% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

What is Spero Therapeuti's EBITDA?

Spero Therapeuti (SPRO) had EBITDA of -$73.4M in fiscal year 2024, measuring earnings before interest, taxes, depreciation, and amortization.

What is Spero Therapeuti's operating margin?

Spero Therapeuti (SPRO) had an operating margin of -152.9% in fiscal year 2024, reflecting the profitability of core business operations before interest and taxes.

What is Spero Therapeuti's net profit margin?

Spero Therapeuti (SPRO) had a net profit margin of -142.9% in fiscal year 2024, representing the share of revenue converted into profit after all expenses.

What is Spero Therapeuti's operating cash flow?

Spero Therapeuti (SPRO) generated -$23.4M in operating cash flow during fiscal year 2024, representing cash generated from core business activities.

What are Spero Therapeuti's total assets?

Spero Therapeuti (SPRO) had $110.5M in total assets as of fiscal year 2024, including both current and long-term assets.

How much does Spero Therapeuti spend on research and development?

Spero Therapeuti (SPRO) invested $96.8M in research and development during fiscal year 2024.

How many shares does Spero Therapeuti have outstanding?

Spero Therapeuti (SPRO) had 55M shares outstanding as of fiscal year 2024.

What is Spero Therapeuti's current ratio?

Spero Therapeuti (SPRO) had a current ratio of 2.19 as of fiscal year 2024, which is generally considered healthy.

What is Spero Therapeuti's debt-to-equity ratio?

Spero Therapeuti (SPRO) had a debt-to-equity ratio of 1.40 as of fiscal year 2024, measuring the company's financial leverage by comparing total debt to shareholder equity.

What is Spero Therapeuti's return on assets (ROA)?

Spero Therapeuti (SPRO) had a return on assets of -62.0% for fiscal year 2024, measuring how efficiently the company uses its assets to generate profit.

What is Spero Therapeuti's cash runway?

Based on fiscal year 2024 data, Spero Therapeuti (SPRO) had $52.9M in cash against an annual operating cash burn of $23.4M. This gives an estimated cash runway of approximately 27 months at the current burn rate. Cash runway measures how long a company can continue operating before running out of cash, assuming no additional funding.

What is Spero Therapeuti's Piotroski F-Score?

Spero Therapeuti (SPRO) has a Piotroski F-Score of 1 out of 9, indicating weak financial health. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7–9 indicate strong and improving fundamentals.

Are Spero Therapeuti's earnings high quality?

Spero Therapeuti (SPRO) has an earnings quality ratio of 0.34x, considered low quality (accrual-driven). This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation.

How financially healthy is Spero Therapeuti?

Spero Therapeuti (SPRO) scores 32 out of 100 on our Financial Profile, indicating weak overall financial health. This composite score evaluates six dimensions: profitability (operating margin), revenue growth, leverage (debt-to-equity), liquidity (current ratio), cash flow quality (free cash flow margin), and shareholder returns (return on equity). Each dimension is normalized against standard financial benchmarks.