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Agilent to Appeal Patent Office Decision on CRISPR gRNA Patents
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Rhea-AI Summary
Agilent Technologies plans to appeal the U.S. Patent and Trademarks Office's decision regarding the Inter Partes review of its patents related to CRISPR guide RNA. The company disagrees with the opinion of unpatentability and believes in the innovative contributions made by its scientists. The decision does not affect Agilent's ability to make or sell chemically modified gRNA guides.
Positive
Agilent intends to appeal the USPTO's decision, showing confidence in its patents and continued leadership in CRISPR technologies.
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SANTA CLARA, Calif.--(BUSINESS WIRE)--
Agilent Technologies Inc. (NYSE: A), announced today the company intends to appeal the U.S. Patent and Trademarks Office (USPTO) Patent Trial and Appeal Board’s (PTAB) Final Written Decision in connection with the Inter Partes review (IPR) of U.S. Patent Nos. 10,337,001 & 10,900,034 (the Agilent Patents). The PTAB recently reversed the USPTO’s original decision granting claims directed towards chemically modified synthetic CRISPR guide RNA.
Agilent respectfully disagrees with the PTAB’s opinion of unpatentability in view of prior art previously considered by the USPTO during its primary examination. The work presented in the two Agilent Patents is also discussed in a publication as part of a broader collaboration with Stanford University in the widely cited paper: Hendel, Ayal et al. “Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells.” Nature biotechnology vol. 33,9 (2015): 985-989. doi:10.1038/nbt.3290.
The Agilent Patents describe synthesis and testing of hundreds of chemically modified CRISPR guide RNA molecules that were shown to improve the efficiency of CRISPR-based gene editing. Prior to the work done by Agilent’s inventors, it was not known whether the many chemical modifications Agilent made to the various and long guide RNAs would disrupt functionality of the gRNA:Cas enzyme complex. That answer was discovered and disclosed by the Agilent inventors as a multidisciplinary team and using Agilent’s own patented chemical synthesis methods.
Building upon its years of expertise in nucleic acid synthesis, Agilent offers the scientific community both research-grade and cGMP-grade guide RNA products incorporating chemical modifications. Agilent’s SureGuide research-grade gRNA products are made and sold in Agilent’s production facility in Santa Clara, California. Agilent’s Nucleic Acid Solutions Division makes and sells its large-scale, cGMP-grade ClinGuide products in its state-of-the art production facilities headquartered in Boulder, Colorado.
Agilent is confident in the innovative contributions made by its scientists and intends to appeal to the United States Court of Appeals for the Federal Circuit. This patent family also remains open with ongoing prosecution of new claims. Agilent’s Patents will persist until all appeals have been exhausted, and the PTAB decision does not affect Agilent’s continued leadership in CRISPR technologies as a provider of superior-quality guide RNAs. The PTAB’s decision in no way affects Agilent’s ability to make or sell chemically modified gRNA guides.
About Agilent Technologies
Agilent Technologies Inc. (NYSE: A) is a global leader in analytical and clinical laboratory technologies, delivering insights and innovation that help our customers bring great science to life. Agilent’s full range of solutions includes instruments, software, services, and expertise that provide trusted answers to our customers' most challenging questions. The company generated revenue of $6.85 billion in fiscal 2022 and employs 18,000 people worldwide. Information about Agilent is available at www.agilent.com. To receive the latest Agilent news, subscribe to the Agilent Newsroom. Follow Agilent on LinkedIn and Facebook.
Agilent Technologies is appealing the U.S. Patent and Trademarks Office's decision regarding its patents related to CRISPR guide RNA.
What does the decision by the PTAB mean for Agilent?
The decision does not affect Agilent's ability to make or sell chemically modified gRNA guides.
Where are Agilent's gRNA products made and sold?
Agilent's SureGuide research-grade gRNA products are made and sold in Santa Clara, California, while its large-scale, cGMP-grade ClinGuide products are made and sold in Boulder, Colorado.
What does Agilent's patent family include?
Agilent's patent family includes ongoing prosecution of new claims and will persist until all appeals have been exhausted.
analytical scientists and clinical researchers worldwide rely on agilent to help fulfill their most complex laboratory demands. our instruments, software, services and consumables address the full range of scientific and laboratory management needs—so our customers can do what they do best: improve the world around us. whether a laboratory is engaged in environmental testing, academic research, medical diagnostics, pharmaceuticals, petrochemicals or food testing, agilent provides laboratory solutions to meet their full spectrum of needs. we work closely with customers to help address global trends that impact human health and the environment, and to anticipate future scientific needs. our solutions improve the efficiency of the entire laboratory, from sample prep to data interpretation and management. customers trust agilent for solutions that enable insights...for a better world.
