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AbbVie Announces UK Pricing Strategy for ELAHERE® (mirvetuximab soravtansine-gynx)

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AbbVie (NYSE:ABBV) has announced its pricing strategy for ELAHERE® (mirvetuximab soravtansine-gynx) in the UK, setting the list price equal to US levels. ELAHERE is the first-and-only approved FRα-directed antibody drug conjugate (ADC) for treating platinum-resistant ovarian cancer patients who have received 1-3 prior treatments.

The company is currently in discussions with NICE to ensure fair valuation of ELAHERE, which represents the first new treatment in 10 years for platinum-resistant ovarian cancer in the UK. The drug received MHRA approval in July 2025, following FDA approval in March 2024 and European Commission approval in November 2024.

AbbVie (NYSE:ABBV) ha annunciato la sua strategia di prezzo per ELAHERE® (mirvetuximab soravtansine-gynx) nel Regno Unito, fissando il prezzo di listino al livello statunitense. ELAHERE è il primo e unico ADC diretto verso FRα approvato per trattare pazienti con cancro ovarico resistente al platinum che hanno ricevuto 1-3 trattamenti precedenti.

L'azienda è attualmente in trattative con NICE per garantire una valutazione equa di ELAHERE, che rappresenta il primo nuovo trattamento in 10 anni per il cancro ovarico resistente al platinum nel Regno Unito. Il farmaco ha ottenuto l'approvazione MHRA nel luglio 2025, seguito dall'approvazione FDA nel marzo 2024 e dall'approvazione della Commissione Europea nel novembre 2024.

AbbVie (NYSE:ABBV) ha anunciado su estrategia de fijación de precios para ELAHERE® (mirvetuximab soravtansine-gynx) en el Reino Unido, estableciendo el precio de lista al mismo nivel que en EE. UU. ELAHERE es el primer y único conjugado anticuerpo-drug (ADC) dirigido a FRα para el tratamiento de pacientes con cáncer de ovario resistente al platino que han recibido 1-3 tratamientos previos.

La empresa se encuentra actualmente en conversaciones con NICE para garantizar una valoración justa de ELAHERE, que representa el primer nuevo tratamiento en 10 años para el cáncer de ovario resistente al platino en el Reino Unido. El fármaco obtuvo la aprobación de MHRA en julio de 2025, tras la aprobación de la FDA en marzo de 2024 y la aprobación de la Comisión Europea en noviembre de 2024.

AbbVie (NYSE:ABBV)는 영국에서 ELAHERE® (mirvetuximab soravtansine-gynx)의 가격 전략을 발표했으며, 목록가를 미국 수준과 동일하게 설정했습니다. ELAHERE는 FRα 지시 항체-약물 접합체(ADC)로서 백금-저항성 난소암 환자(이전 치료 1-3회) 치료에 대한 최초이자 유일한 승인 치료제입니다.

회사는 현재 NICE와의 논의를 통해 ELAHERE의 공정한 평가를 보장하려 하고 있으며, 이는 영국에서 백금-저항성 난소암에 대한 지난 10년간의 최초의 새로운 치료법을 나타냅니다. 이 약은 2025년 7월 MHRA 승인을 받았으며, 그 전 2024년 3월 FDA 승인, 2024년 11월 유럽위원회 승인을 받았습니다.

AbbVie (NYSE:ABBV) a annoncé sa stratégie de tarification pour ELAHERE® (mirvetuximab soravtansine-gynx) au Royaume-Uni, en fixant le prix de liste au même niveau que les États-Unis. ELAHERE est la première et unique thérapie ciblant FRα sous forme d’ADC approuvée pour le traitement du cancer de l’ovaire résistant au platine chez des patientes ayant reçu 1 à 3 traitements antérieurs.

L’entreprise est actuellement en discussion avec NICE pour assurer une évaluation équitable d’ELAHERE, qui représente la première nouvelle option de traitement en 10 ans pour le cancer de l’ovaire résistant au platine au Royaume-Uni. Le médicament a reçu l’approbation MHRA en juillet 2025, après l’approbation de la FDA en mars 2024 et l’approbation de la Commission européenne en novembre 2024.

AbbVie (NYSE:ABBV) hat seine Preisstrategie für ELAHERE® (mirvetuximab soravtansine-gynx) im Vereinigten Königreich bekanntgegeben und dabei den Listenpreis auf das US-Niveau festgelegt. ELAHERE ist der erste und einzige FRα-ausgerichtete Antikörper-Drogen-Verbindung (ADC), die zur Behandlung von platinresistentem Eierstockkrebs bei Patientinnen mit 1-3 vorangegangenen Behandlungen zugelassen ist.

Das Unternehmen führt derzeit Gespräche mit NICE, um eine faire Bewertung von ELAHERE sicherzustellen, was die erste neue Behandlung in 10 Jahren für platinresistenten Ovarialkrebs im Vereinigten Königreich darstellt. Das Medikament erhielt die MHRA-Zulassung im Juli 2025, nach der FDA-Zulassung im März 2024 und der Zulassung durch die Europäische Kommission im November 2024.

أبڤي (NYSE:ABBV) أعلنت عن استراتيجية التسعير لـ ELAHERE® (mirvetuximab soravtansine-gynx) في المملكة المتحدة، بتثبيت سعر القائمة عند المستوى نفسه كما في الولايات المتحدة. ELAHERE هو أول وأفضل مركّب مضاد للجسم-دواء موجّه إلى FRα (ADC) معتمد لعلاج سرطان المبيض المقاوم للبلاتين عند النساء اللواتي خضعن لعلاج سابق من 1-3 جولات.

الشركة تجري حالياً مناقشات مع NICE لضمان تقييم عادل لـ ELAHERE، الذي يمثل أول علاج جديد خلال 10 سنوات لسرطان المبيض المقاوم للبلاتين في المملكة المتحدة. حصل الدواء على موافقة MHRA في يوليو 2025، تلاها موافقة FDA في مارس 2024 وموافقة المفوضية الأوروبية في نوفمبر 2024.

AbbVie (NYSE:ABBV)宣布了在英国对 ELAHERE®(mirvetuximab soravtansine-gynx)的定价策略,将目录价格设定为美国水平。ELAHERE 是面向 FRα 的第一款也是唯一获批的 ADC(抗体-药物偶联物),用于治疗接受过 1-3 次先前治疗的铂类耐药性卵巢癌患者。

公司目前正在与 NICE 进行磋商,以确保对 ELAHERE 的公允估值,这也标志着英国铂类耐药性卵巢癌在过去 10 年来首次推出的新治疗方案。该药于 2025 年 7 月获得 MHRA 批准,之前分别在 2024 年 3 月获得 FDA 批准、2024 年 11 月获得欧盟委员会批准。

Positive
  • First new treatment approved in 10 years for platinum-resistant ovarian cancer in the UK
  • Already secured key regulatory approvals: FDA, European Commission, and MHRA
  • Addresses significant unmet need in ovarian cancer treatment
Negative
  • UK market access depends on ongoing NICE price negotiations
  • Higher US-level pricing strategy may face challenges in UK market acceptance

Insights

AbbVie's equal US-UK pricing for ELAHERE signals stronger global pricing power and potential revenue growth, despite UK market access challenges.

AbbVie's announcement to price ELAHERE at US levels in the UK represents a significant strategic shift in pharmaceutical pricing approaches. This antibody-drug conjugate (ADC) for platinum-resistant ovarian cancer is positioned as a premium-priced innovation, breaking from the typical pattern of lower European pricing compared to US markets.

This pricing strategy signals AbbVie's confidence in ELAHERE's clinical value proposition. As the first new treatment in a decade for platinum-resistant ovarian cancer and the only FRα-directed ADC, AbbVie clearly believes it can command premium pricing globally based on therapeutic differentiation rather than market-by-market negotiations.

The timing is particularly noteworthy as AbbVie faces the upcoming $12+ billion Humira revenue cliff. ELAHERE represents part of AbbVie's strategy to offset these losses through high-value oncology assets. However, this approach carries substantial risk in the UK market, where NICE's cost-effectiveness thresholds are notoriously stringent.

The explicit statement that "the value given to ELAHERE will determine the ability to launch in the UK" suggests AbbVie is prepared to delay or forego the UK market if price concessions are demanded. This represents an unusually aggressive negotiating stance with NICE, effectively challenging the UK system to fully recognize innovation value or lose access.

While ambitious, this approach may encounter significant resistance from UK payers, potentially delaying patient access. For investors, this signals AbbVie's commitment to maintaining global premium pricing for breakthrough therapies, which could positively impact long-term revenue projections if successful, but poses near-term market access challenges in price-sensitive markets.

  • The list price will be consistent with the United States to reflect the value of the innovation
  • AbbVie is committed to ensuring that developed nations fully recognize the value of our medicines in improving patient outcomes, consistent with the level of recognition in the United States

NORTH CHICAGO, Ill., Sept. 29, 2025 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced plans to launch ELAHERE® (mirvetuximab soravtansine-gynx) in the U.K. at a list price equal to the U.S., reflecting the advanced innovation and value of the treatment for adult patients with folate receptor-alpha (FRα) positive, platinum-resistant high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment regimens.1 ELAHERE is the first-and-only approved FRα-directed antibody drug conjugate (ADC) medicine.

"Scientific progress in treating ovarian cancer and other serious diseases requires a collaborative approach among all developed nations," said Jeff Stewart, executive vice president and chief commercial officer, AbbVie. "Developed markets must recognize and support the value that innovative therapies bring to patients and societies to help ensure sustainable access and continued investment in medical innovation so that patients everywhere benefit from the next generation of therapies."

AbbVie is in discussions with the National Institute for Health and Care Excellence (NICE) to ensure that ELAHERE, which will address a significant unmet need among women suffering from ovarian cancer, is valued fairly. The value given to ELAHERE will determine the ability to launch in the U.K.

Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide.2 More than 200,000 women die with the disease globally every year.2 ELAHERE is the first new treatment in 10 years to be licensed for the treatment of women in the U.K. with platinum-resistant ovarian cancer.

The European Commission granted approval of ELAHERE in November 2024 and was granted full FDA approval in the U.S. in March 2024. In July, the Medicines and Healthcare products Regulatory Agency (MHRA) approved ELAHERE, reinforcing that enabling access to high-quality, safe and effective medical products is a priority.3

About ELAHERE® (mirvetuximab soravtansine-gynx)

ELAHERE is a first-in-class antibody drug conjugate (ADC) composed of a folate receptor alpha binding antibody, cleavable linker, and the maytansinoid payload DM4, a potent tubulin inhibitor designed to kill the targeted cancer cells.

Mirvetuximab soravtansine (approved under the brand name ELAHERE®) was granted approval by the European Commission in November 2024, and was granted full FDA approval in the United States in March 2024.

Marketing authorization submissions for mirvetuximab soravtansine are under review in multiple other countries.

ELAHERE U.S. USE and IMPORTANT SAFETY INFORMATION 

What is ELAHERE?

ELAHERE is a prescription medicine used to treat adults with folate receptor-alpha positive ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who:

  • have not responded to or are no longer responding to treatment with platinum-based chemotherapy and
  • have received 1 to 3 prior types of chemotherapy.

Your healthcare provider will perform a test to make sure that ELAHERE is right for you.
It is not known if ELAHERE is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ELAHERE?

ELAHERE can cause serious side effects, including:

Eye problems. Eye problems are common with ELAHERE and can also be severe. Tell your healthcare provider right away if you develop any eye problems during treatment with ELAHERE, including blurred vision, dry eyes, sensitivity to light, eye pain, eye redness, or new or worsening vision changes.

  • Your healthcare provider will send you to see an eye care professional to check your eyes before you start treatment with ELAHERE, during treatment with ELAHERE, and as needed for any worsening signs and symptoms of eye problems.
  • Your healthcare provider will prescribe steroid eye drops and lubricating eye drops before you start and during your treatment with ELAHERE. You should use eye drops as directed by your healthcare provider.
  • Do not wear contact lenses throughout your treatment with ELAHERE unless you are told to use them by your healthcare provider.

What should I tell my healthcare provider before receiving ELAHERE?

Tell your healthcare provider about all of your medical conditions, including if you:

  • have vision or eye problems.
  • have numbness or tingling in your hands or feet.
  • have liver problems.
  • are pregnant or plan to become pregnant. ELAHERE can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ELAHERE.

Patients who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with ELAHERE.
    • You should use an effective birth control (contraception) during treatment and for 7 months after your last dose of ELAHERE.
  • are breastfeeding or plan to breastfeed. It is not known if ELAHERE passes into your breast milk. Do not breastfeed during treatment and for 1 month after your last dose of ELAHERE.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking certain other medicines during treatment with ELAHERE may cause side effects.

What are the possible side effects of ELAHERE?

ELAHERE can cause serious side effects, including:

  • Eye problems. Eye problems are common with ELAHERE and can also be severe. Tell your healthcare provider right away if you develop any eye problems during treatment with ELAHERE, including blurred vision, dry eyes, sensitivity to light, eye pain, eye redness, or new or worsening vision changes.
  • Lung problems (pneumonitis). ELAHERE can cause severe or life-threatening inflammation of the lungs that may lead to death. Tell your healthcare provider right away if you get new or worsening symptoms, including trouble breathing, shortness of breath, cough, or chest pain.
  • Peripheral neuropathy. Nerve problems called peripheral neuropathy are common during treatment with ELAHERE and can also be severe. Your healthcare provider will monitor you for signs and symptoms of nerve problems. Tell your healthcare provider if you get new or worsening numbness, tingling, burning sensation or pain in your hands or feet or muscle weakness.

The most common side effects and abnormal labs of ELAHERE include:

•      increased liver enzymes in the blood

•      feeling tired

•      blurred vision

•      nausea

•      diarrhea

•      stomach-area (abdominal) pain

•      changes in the cornea (part of the eye)

•      peripheral neuropathy

•      muscle, bone, or joint pain

•      decreased red or white blood cell counts

•     decreased platelets

•     decreased magnesium level in the blood

•     dry eye

•     constipation

•     vomiting

•     decreased albumin level in the blood

•     decreased appetite

Your healthcare provider may change your dose of ELAHERE, delay treatment, or completely stop treatment if you have certain side effects.

These are not all of the possible side effects of ELAHERE. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

Please see  Full Prescribing Information , including Boxed WARNING and  Medication Guide .

Globally, prescribing information varies; refer to the individual country product label for complete information.

About AbbVie in Oncology
AbbVie is committed to elevating standards of care and bringing transformative therapies to patients worldwide living with difficult-to-treat cancers. We are advancing a dynamic pipeline of investigational therapies across a range of cancer types in both blood cancers and solid tumors. We are focusing on creating targeted medicines that either impede the reproduction of cancer cells or enable their elimination. We achieve this through various, targeted treatment modalities and biology interventions, including small molecule therapeutics, antibody-drug conjugates (ADCs), immuno-oncology-based therapeutics, multispecific antibody and novel CAR-T platforms. Our dedicated and experienced team joins forces with innovative partners to accelerate the delivery of potential breakthrough medicines.

Today, our expansive oncology portfolio comprises approved and investigational treatments for a wide range of blood cancers and solid tumors. We are evaluating more than 35 investigational medicines in multiple clinical trials across some of the world's most widespread and debilitating cancers. As we work to have a remarkable impact on people's lives, we are committed to exploring solutions to help patients obtain access to our cancer medicines. For more information, please visit http://www.abbvie.com/oncology.

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology, neuroscience and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X (formerly Twitter) and YouTube.

Forward-Looking Statements 

Some statements in this news release are, or may be considered, forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions and uses of future or conditional verbs, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, changes to laws and regulations applicable to our industry, the impact of global macroeconomic factors, such as economic downturns or uncertainty, international conflict, trade disputes and tariffs, and other uncertainties and risks associated with global business operations. Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," of AbbVie's 2024 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission, as updated by its Quarterly Reports on Form 10-Q and in other documents that AbbVie subsequently files with the Securities and Exchange Commission that update, supplement or supersede such information. AbbVie undertakes no obligation, and specifically declines, to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law.

Global Media:

Marianne Ostrogorski

+1 (224) 240-6336

marianne.ostrogorski@abbvie.com

Investors: 

Liz Shea

+1 (847) 935-2211

Liz.Shea@abbvie.com 

References

1ELAHERE. Summary of Product Characteristics. Available from: https://www.ema.europa.eu/en/documents/product-information/elahere-epar-product-information_en.pdf.

2WHO International Agency for Research on Cancer. GLOBOCAN 2022. Cancer Today. Absolute numbers, Mortality, Females, age [0-74], in 2022. Available from: https://gco.iarc.who.int/media/globocan/factsheets/populations/900-world-fact-sheet.pdf.

3Mirvetuximab soravtansine approved to treat adult patients who have ovarian, fallopian tube or primary peritoneal cancer. https://www.gov.uk/government/news/mirvetuximab-soravtansine-approved-to-treat-adult-patients-who-have-ovarian-fallopian-tube-or-primary-peritoneal-cancer.

Cision View original content:https://www.prnewswire.com/news-releases/abbvie-announces-uk-pricing-strategy-for-elahere-mirvetuximab-soravtansine-gynx-302569509.html

SOURCE AbbVie

FAQ

What is the UK pricing strategy for AbbVie's ELAHERE?

AbbVie plans to launch ELAHERE in the UK at a list price equal to the US price, reflecting the treatment's advanced innovation and value.

What approvals has ELAHERE received so far?

ELAHERE received FDA approval in March 2024, European Commission approval in November 2024, and MHRA approval in July 2025.

What type of cancer does ELAHERE treat?

ELAHERE treats FRα-positive, platinum-resistant high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer in adult patients who have received 1-3 prior systemic treatments.

When did ABBV receive MHRA approval for ELAHERE in the UK?

The Medicines and Healthcare products Regulatory Agency (MHRA) approved ELAHERE in July 2025.

What is unique about ELAHERE in ovarian cancer treatment?

ELAHERE is the first-and-only approved FRα-directed antibody drug conjugate (ADC) and the first new treatment in 10 years for platinum-resistant ovarian cancer in the UK.
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