AbbVie Inc. reports pharmaceutical developments across immunology, neuroscience, oncology and Allergan Aesthetics. Recurring updates include financial results by product portfolio, clinical and real-world data for therapies such as SKYRIZI and RINVOQ, FDA regulatory submissions and response letters, and medical-conference presentations in inflammatory bowel disease and other immune-mediated conditions.
Company news also covers pipeline spending, acquired in-process research and development, manufacturing capacity for medicines in core therapeutic areas, and investor conference appearances. AbbVie’s product references commonly include SKYRIZI, RINVOQ, Botox Therapeutic, Vraylar, Ubrelvy, Qulipta, Venclexta, Imbruvica and Elahere.
AbbVie (NYSE: ABBV) has released positive results from the Phase 3 SELECT-PsA 2 clinical trial of RINVOQ® (upadacitinib, 15 mg, once daily), showing sustained improvements in active psoriatic arthritis for over one year. At week 56, 29% of patients achieved minimal disease activity, and 60% achieved ACR20 response. The study also reported improvements in skin clearance and no new significant safety issues. These results highlight RINVOQ's potential in managing psoriatic arthritis symptoms long-term, supporting its recent EU approval for this indication.
AbbVie announced new data presented at EULAR 2021, showing RINVOQ (upadacitinib) 15 mg leads to higher rates of clinical remission and low disease activity in moderate to severe rheumatoid arthritis patients compared to HUMIRA (adalimumab) over three years. Clinical remission was achieved in 32% of RINVOQ patients versus 22% with HUMIRA. The safety profile of RINVOQ remained consistent over 4.5 years, with no new risks identified. Overall, this data reinforces the efficacy and safety of RINVOQ as a treatment option.
AbbVie (NYSE: ABBV) will participate in Bernstein's 37th Annual Strategic Decisions Conference on June 2, 2021, at 2:30 p.m. Central Time. Presenters will include Michael Severino, M.D., vice chairman and president, and Robert A. Michael, executive vice president and CFO. A live audio webcast will be available on AbbVie's Investor Relations website, with an archived edition posted later the same day. AbbVie is committed to developing innovative medicines across various therapeutic areas, including immunology, oncology, and neurology.
AbbVie (NYSE: ABBV) will present key data from its migraine portfolio at the 2021 American Headache Society Annual Scientific Meeting, scheduled for June 3-6. A total of 23 abstracts, including four podium presentations, will cover significant findings on preventive and acute migraine treatments, highlighting atogepant and UBRELVY®. Dr. Mitchell Mathis emphasized the importance of these advancements in addressing the debilitating impact of migraines on millions. Presentations will include studies on treatment gaps, efficacy, and patient quality of life, showcasing AbbVie's commitment to the migraine community.
AbbVie (NYSE: ABBV) has received European Commission approval for VENCLYXTO (venetoclax) in combination with hypomethylating agents azacitidine or decitabine. This treatment is aimed at adult patients with newly diagnosed acute myeloid leukemia (AML) who cannot undergo intensive chemotherapy. The approval applies to all 27 EU member states, Iceland, Liechtenstein, and Norway. Clinical trials indicate that this combination improves overall survival compared to azacitidine alone, marking a significant advancement in AML treatment options.
AbbVie (NYSE: ABBV) announced it will present 41 abstracts on its immunology assets at the EULAR 2021 Virtual Congress from June 2-5. Key data includes RINVOQ efficacy and safety results for rheumatoid arthritis (RA) and psoriatic arthritis (PsA) from one to three years. Additionally, integrated safety data from Phase 3 SELECT trials for RINVOQ will be discussed, highlighting AbbVie's focus on advancing treatment for rheumatic diseases. The company's commitment to innovation in rheumatology is underscored by these presentations.
AbbVie presented late-breaking data from two Phase 3 studies, ADVANCE and MOTIVATE, at the DDW 2021 Conference, showcasing the efficacy of investigational drug risankizumab in treating moderately to severely active Crohn's disease. Patients receiving 600 mg or 1200 mg of risankizumab demonstrated significantly higher rates of clinical remission and endoscopic response compared to placebo, with p-values 0.001. The safety profile was consistent with previous trials, showing lower rates of serious adverse events compared to placebo. Results are submitted for publication, with ongoing studies for maintenance therapy.
On May 24, 2021, AbbVie announced that The Lancet published primary analysis results from pivotal Phase 3 clinical trials (Measure Up 1, Measure Up 2, and AD Up) assessing RINVOQ (upadacitinib) for treating moderate to severe atopic dermatitis in adults and adolescents. The studies demonstrated that RINVOQ met all primary and secondary endpoints, showcasing its efficacy and safety when compared to placebo. The results indicate potential advancements in treatment options for atopic dermatitis, affecting a significant percentage of the population.
AbbVie will participate in the UBS Global Healthcare Virtual Conference on May 25, 2021, at 11:00 a.m. Central time. Key executives participating include Michael Severino, Robert A. Michael, and Jeffrey R. Stewart. A live audio webcast will be available on AbbVie’s Investor Relations website, with an archived version accessible later the same day. AbbVie is dedicated to developing innovative medicines across various therapeutic areas such as immunology, oncology, and neuroscience.
AbbVie (NYSE: ABBV) will present results from 43 abstracts across 12 cancers at the ASCO Annual Meeting (June 4-8) and EHA Congress (June 9-17). Key presentations include data on the CAPTIVATE study concerning chronic lymphocytic leukemia (CLL) patients treated with an ibrutinib and venetoclax combination. Notable highlights include long-term data from various trials such as CLL14 and MURANO. These presentations aim to advance blood cancer treatment and showcase AbbVie's expanding oncology portfolio, reflecting its commitment to improving patient outcomes.