Welcome to our dedicated page for Acumen Pharmaceuticals news (Ticker: ABOS), a resource for investors and traders seeking the latest updates and insights on Acumen Pharmaceuticals stock.
Acumen Pharmaceuticals (NASDAQ: ABOS) operates at the intersection of neuroscience research and clinical drug development, making its news particularly relevant for investors tracking Alzheimer's disease therapeutics. As a clinical-stage biopharmaceutical company targeting amyloid-beta oligomers, Acumen generates news tied directly to scientific milestones and regulatory progress.
News coverage for Acumen typically includes clinical trial updates such as patient enrollment progress, study design announcements, and data readouts from ongoing trials. The company also announces research presentations at medical conferences where scientists share findings on drug candidates and disease biology. These conference presentations often precede or accompany peer-reviewed publications.
Partnership announcements represent another important news category for Acumen. Collaborations with other pharmaceutical companies, academic institutions, or contract research organizations can expand the company's development capabilities and validate its therapeutic approach. Such deals may include licensing agreements, research collaborations, or manufacturing partnerships.
Financial news includes quarterly earnings reports detailing cash position and research spending, which are critical metrics for pre-revenue biotechnology companies. Capital raises, public offerings, and financing transactions directly impact the company's ability to fund ongoing clinical programs.
Tracking Acumen's news flow provides insight into the progress of Alzheimer's disease research and the clinical development timeline for oligomer-targeting therapies. Bookmark this page to follow material developments as they occur.
Acumen Pharmaceuticals (NASDAQ: ABOS) presented new preclinical and clinical-trial recruitment data at the 18th Annual CTAD conference on December 1-4, 2025. A collaborative study with JCR Pharmaceuticals showed that fusing transferrin receptor (TfR) binders to AβO-targeting antibodies (including sabirnetug/ACU193) produced 15–68 fold increases in brain penetration in mice while preserving target binding. Acumen and JCR are developing TfR-targeting antibodies for clinical testing. Recruitment analysis from the Phase 2 ALTITUDE-AD trial tracked 2,362 screened across 76 sites with 542 enrolled, finding site databases and physician referrals were the most reliable recruitment methods.
Acumen Pharmaceuticals (NASDAQ: ABOS) announced on Nov 17, 2025 that the first participant was dosed in the open-label extension (OLE) of its Phase 2 ALTITUDE-AD trial of sabirnetug (ACU193) in people with early Alzheimer’s disease.
The OLE offers participants who completed the 18-month placebo-controlled portion additional dosing of 35 mg/kg IV every four weeks for 52 weeks. Clinical measures and safety monitoring remain the same. The company cited Phase 1 INTERCEPT-AD results showing favorable safety, low ARIA-E rates, target engagement, and biomarker effects including amyloid plaque reduction at highest doses. Acumen expects topline ALTITUDE-AD results in late 2026.
Acumen Pharmaceuticals (NASDAQ: ABOS) reported Q3 2025 results and a business update on Nov. 12, 2025. The company had $136.1 million in cash, cash equivalents and marketable securities as of Sept. 30, 2025, which it expects will support operations into early 2027. Acumen continues its Phase 2 ALTITUDE-AD study of sabirnetug (ACU193) and began dosing the open-label extension in Nov. 2025. The company expects non-clinical data for its Enhanced Brain Delivery program in early 2026 and Phase 2 topline results for ALTITUDE-AD in late 2026. Q3 R&D expense was $22.0M and net loss was $26.5M.
Acumen Pharmaceuticals (NASDAQ: ABOS) announced that George Golumbeski, Ph.D. has been appointed Chairman of its Board of Directors, bringing more than 30 years of biopharma experience.
The Board now totals eight members. Management highlighted Golumbeski’s expertise in portfolio strategy, collaborations, licensing and M&A and said his experience aligns with anticipated catalysts next year for Acumen’s Phase 2 sabirnetug trial and its Enhanced Brain Delivery program.
Acumen Pharmaceuticals (NASDAQ: ABOS) announced it will report third quarter 2025 financial results on Wednesday, November 12, 2025. The company will host a conference call and live audio webcast at 8:00 a.m. ET to provide a business and financial update.
Investors must register in advance to receive dial-in numbers and PIN; the live webcast link will be provided and an archived webcast will be available for at least 30 days in the Investors section of the company website.
Acumen Pharmaceuticals (NASDAQ: ABOS) said management will participate in a fireside chat at the Stifel Healthcare Conference on Tuesday, Nov. 11, 2025 at 4:40 p.m. ET. The company is a clinical-stage biopharmaceutical developer focused on therapeutics targeting toxic soluble amyloid beta oligomers for Alzheimer’s disease. A live webcast will be available via the company Investors page and archived for 90 days.
Acumen Pharmaceuticals (NASDAQ: ABOS), a clinical-stage biopharmaceutical company focused on developing treatments for Alzheimer's disease, has announced its participation in two upcoming investor conferences in September 2025.
The company will participate in Citi's 2025 Biopharma Back to School Conference with a fireside chat on September 2 at 3:15 p.m. ET, and the Cantor Global Healthcare Conference 2025 with a fireside chat on September 5 at 9:10 a.m. ET. Both presentations will be available via webcast on the company's website for 90 days.
Acumen Pharmaceuticals (NASDAQ: ABOS) reported Q2 2025 financial results and business updates for its Alzheimer's disease therapeutics development. The company maintains a strong cash position of $166.2 million as of June 30, 2025, expected to fund operations into early 2027.
Key developments include operational innovations in the ALTITUDE-AD Phase 2 trial of sabirnetug, achieving 40% reduction in screening costs through innovative biomarker testing. The company also announced a collaboration with JCR Pharmaceuticals to develop Enhanced Brain Delivery (EBD™) therapy, combining sabirnetug with JCR's blood-brain barrier-penetrating technology.
Financial results show R&D expenses increased to $37.1 million from $19.5 million year-over-year, while net loss widened to $41.0 million from $20.5 million. Topline results from ALTITUDE-AD are expected in late 2026.
Acumen Pharmaceuticals (NASDAQ: ABOS), a clinical-stage biopharmaceutical company focused on developing treatments for Alzheimer's disease, has scheduled its second quarter 2025 financial results announcement for August 12, 2025.
The company will host a conference call and audio webcast at 8:00 a.m. ET to discuss business updates and financial performance. Participants must pre-register at least one day in advance to receive dial-in information. The webcast will be archived for 30 days on Acumen's investor relations website.
Acumen Pharmaceuticals (NASDAQ: ABOS) presented significant findings at the Alzheimer's Association International Conference (AAIC) 2025 regarding their Phase 2 ALTITUDE-AD study of sabirnetug for early Alzheimer's disease. The company reported a 40% reduction in clinical trial screening costs through an innovative pTau217 blood-based screening assay.
The two-step screening process demonstrated high efficiency, with 48% of participants meeting initial pTau217 thresholds and 81% of those subsequently confirming amyloid positivity. Additionally, nonclinical studies revealed sabirnetug's superior selectivity for amyloid beta oligomers (AβOs), achieving 8,750-fold selectivity for Aβ1-42 stabilized oligomers over Aβ1-40 monomers, outperforming other tested antibodies including lecanemab and aducanumab.
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