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Acumen Pharmaceuticals, Inc. - $ABOS STOCK NEWS

Welcome to our dedicated page for Acumen Pharmaceuticals news (Ticker: $ABOS), a resource for investors and traders seeking the latest updates and insights on Acumen Pharmaceuticals stock.

Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS), headquartered in Charlottesville, VA with additional offices in Indianapolis, IN and Newton, MA, is a clinical-stage biopharmaceutical company innovating in the field of Alzheimer's disease (AD) and other neurodegenerative disorders. Acumen's core focus is on the development of novel, disease-modifying treatments by targeting toxic soluble amyloid-beta oligomers (AβOs), which are believed to be a primary underlying cause of AD. The company’s lead therapeutic candidate, sabirnetug (ACU193), is a humanized monoclonal antibody designed to selectively target these AβOs, thereby preventing synaptic dysfunction and neurodegeneration.

Acumen's scientific founders are pioneers in AβO research, contributing to decades of understanding in the field. This extensive research has culminated in the development of sabirnetug, which demonstrated positive topline results from the Phase 1 INTERCEPT-AD clinical trial. The trial showed that sabirnetug is well-tolerated, with a favorable safety profile, and demonstrated statistically significant, dose-related amyloid plaque reduction, validating its proof-of-mechanism.

Currently, Acumen is advancing sabirnetug into the Phase 2 ALTITUDE-AD trial, which aims to further evaluate its clinical efficacy and safety in early Alzheimer's disease. The company is also planning a Phase 1 study to explore a subcutaneous dosing option, enhancing patient accessibility and treatment convenience.

Acumen Pharmaceuticals remains committed to advancing its pioneering research into practical therapeutic solutions. The company's strategic partnerships, including a recent collaboration with Lonza for the manufacturing of sabirnetug, underscore its dedication to bringing effective treatments to market. With a strong financial footing, including $296.6 million in cash and marketable securities as of March 31, 2024, Acumen is well-positioned to support its clinical and operational activities into the first half of 2027.

Acumen’s mission is driven by the urgent need for safe and effective treatment options for Alzheimer's patients. Their work continues to be fueled by robust scientific insights and a commitment to improving the lives of those afflicted by AD.

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Acumen Pharmaceuticals (NASDAQ: ABOS) reported its Q1 2024 financial results and business highlights. The company announced the initiation of ALTITUDE-AD, a Phase 2 study of sabirnetug (ACU193) for early Alzheimer's disease, with the first patient dosed in May 2024. A Phase 1 study for a subcutaneous form of sabirnetug is expected in mid-2024. As of March 31, 2024, Acumen had $296.6 million in cash and equivalents, projected to fund operations into H1 2027. Financial results showed a net loss of $14.9 million, up from $11.3 million YoY. R&D expenses rose to $12.4 million from $8.7 million, while G&A expenses increased to $5.3 million from $4.4 million.

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Acumen Pharmaceuticals (NASDAQ: ABOS), a clinical-stage biopharmaceutical company, announced its participation in the H.C. Wainwright 2nd Annual BioConnect Investor Conference. The company focuses on developing therapeutics targeting toxic soluble amyloid beta oligomers for treating Alzheimer's disease. The management will join a fireside chat scheduled for May 20, 2024, at 12:30 p.m. ET. The event will be available via a live webcast on the company's investor relations page, with an archive accessible for 90 days.

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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) will participate in the 2024 Bank of America Healthcare Conference to discuss their novel therapeutic for treating Alzheimer's disease. The event will take place on May 15, 2024, and can be accessed via a live webcast on their website.

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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) has started the ALTITUDE-AD Phase 2 clinical trial of sabirnetug (ACU193) in early Alzheimer's Disease, representing a significant development in Alzheimer's research. This trial aims to evaluate the efficacy and safety of sabirnetug in patients with early AD, with promising Phase 1 results supporting its mechanism of action. The study will enroll approximately 540 patients with early AD and assess primary and secondary endpoints over 18 months.

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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) will report first quarter 2024 financial results on May 14, 2024. The company is focused on developing a novel therapeutic for Alzheimer's disease. A conference call and webcast will be held to provide a business and financial update.

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Acumen Pharmaceuticals presents comprehensive clinical and biomarker data for Sabirnetug (ACU193) at the American Academy of Neurology 2024 Annual Meeting. The presentation includes insights on safety profile, target engagement, and biomarker changes. Sabirnetug, a humanized monoclonal antibody, shows potential as a next-generation treatment for early Alzheimer's disease.
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Acumen Pharmaceuticals partners with Lonza for manufacturing of sabirnetug, a monoclonal antibody targeting toxic soluble amyloid beta oligomers in Alzheimer's disease. Sabirnetug enters Phase 2 clinical trial in 2024.
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Acumen Pharmaceuticals, Inc. (ABOS) reported financial results for 2023, highlighting Phase 1 success with sabirnetug in Alzheimer's disease treatment. The company plans to initiate Phase 2 and subcutaneous dosing studies in 2024. Cash reserves of $306.1 million support operations till 2027.
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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) is set to present data from its Phase 1 INTERCEPT-AD study evaluating sabirnetug (ACU193) in early Alzheimer's disease at the American Academy of Neurology Annual Meeting. The company's sabirnetug is the first humanized monoclonal antibody to engage AβOs, a toxic form of amyloid beta. Acumen aims to deepen insights into safety, target engagement, and biomarker findings from the study. The company plans to initiate a Phase 2 trial for sabirnetug in the first half of 2024.
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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) will report Q4 and year-end 2023 financial results on March 26, 2024. The company focuses on developing a therapeutic for Alzheimer's disease targeting toxic soluble amyloid beta oligomers.
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FAQ

What is Acumen Pharmaceuticals’ main focus?

Acumen Pharmaceuticals focuses on developing novel treatments targeting toxic soluble amyloid-beta oligomers (AβOs) for Alzheimer's disease and other neurodegenerative diseases.

What is sabirnetug (ACU193)?

Sabirnetug (ACU193) is a humanized monoclonal antibody developed by Acumen Pharmaceuticals to selectively target toxic soluble amyloid-beta oligomers, which are implicated in the pathology of Alzheimer's disease.

What were the results of the Phase 1 INTERCEPT-AD trial?

The Phase 1 INTERCEPT-AD trial demonstrated that sabirnetug was well-tolerated with a favorable safety profile. It showed statistically significant, dose-related amyloid plaque reduction, confirming proof-of-mechanism.

What is the Phase 2 ALTITUDE-AD trial?

The ALTITUDE-AD trial is a Phase 2, multi-center, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the clinical efficacy and safety of sabirnetug in patients with early Alzheimer’s disease.

What are some recent achievements of Acumen Pharmaceuticals?

Recent achievements include the initiation of the Phase 2 ALTITUDE-AD trial, positive results from the Phase 1 INTERCEPT-AD trial, and a manufacturing collaboration with Lonza for sabirnetug.

What is Acumen’s financial condition?

As of March 31, 2024, Acumen Pharmaceuticals has $296.6 million in cash and marketable securities, supporting its clinical and operational activities into the first half of 2027.

Where is Acumen Pharmaceuticals headquartered?

Acumen Pharmaceuticals is headquartered in Charlottesville, VA, with additional offices in Indianapolis, IN, and Newton, MA.

What is the significance of targeting amyloid-beta oligomers (AβOs)?

Targeting AβOs is significant because they are believed to play a critical role in the early and persistent pathology of Alzheimer’s disease, leading to synaptic dysfunction and neurodegeneration.

What future plans does Acumen Pharmaceuticals have for sabirnetug?

Future plans include advancing sabirnetug in the Phase 2 ALTITUDE-AD trial and initiating a Phase 1 study to support a subcutaneous dosing option to enhance patient accessibility.

How can investors get more information about Acumen Pharmaceuticals?

Investors can obtain more information by visiting Acumen Pharmaceuticals' official website at www.acumenpharm.com and accessing the 'Investors' tab for updates and resources.

Acumen Pharmaceuticals, Inc.

Nasdaq:ABOS

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158.61M
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2.06%
Biological Product (except Diagnostic) Manufacturing
Manufacturing
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United States of America
CHARLOTTESVILLE