Welcome to our dedicated page for AC Immune news (Ticker: ACIU), a resource for investors and traders seeking the latest updates and insights on AC Immune stock.
AC Immune SA (NASDAQ: ACIU) generates frequent news flow as a clinical-stage biopharmaceutical company developing precision therapeutics and diagnostics for neurodegenerative diseases. Company updates often center on clinical trial progress for its active immunotherapies and small-molecule programs targeting misfolded proteins implicated in Alzheimer’s disease, Parkinson’s disease and other NeuroOrphan indications.
Investors following ACIU news can expect detailed reports on interim and top-line data from key studies, such as the Phase 2 VacSYn trial of ACI-7104.056 in early Parkinson’s disease and the Phase 2 ABATE and ReTain trials in Alzheimer’s disease. Recent releases have highlighted strong immunogenicity and favorable safety for ACI-7104.056, biomarker trends suggesting potential stabilization of Parkinson’s disease pathology, and peer-reviewed results for the Tau-targeting active immunotherapy ACI-35.030 published in eBioMedicine.
News items also cover AC Immune’s diagnostic imaging efforts, including preclinical and clinical updates on PET tracers like ACI-19626 for TDP-43 pathology, with data published in Nature Communications. Corporate communications frequently include quarterly financial results, cash runway disclosures, pipeline prioritization decisions, workforce adjustments, and information on collaborations with partners such as Janssen, Takeda and Lilly.
This ACIU news page aggregates these company-issued announcements and regulatory communications, giving readers a single place to review clinical milestones, scientific publications, conference presentations and strategic corporate actions. For those tracking AC Immune’s progress in precision prevention of neurodegenerative diseases, it provides an organized view of how the pipeline and partnerships are evolving over time.
AC Immune SA (NASDAQ: ACIU) unveiled a novel class of neurodegenerative disease-fighting drug-candidates called morADC (Morphomer® Antibody Drug Conjugate) at AAIC 2024. This technology combines brain-penetrant Morphomer® small molecules with SupraAntigen® monoclonal antibodies to target toxic proteins in the central nervous system. Key findings include:
1. Significant synergies in blood-brain barrier penetration and protein aggregation inhibition
2. Capability for single or dual-targeting strategies
3. Enhanced anti-aggregation effects compared to parent molecules
4. Multiplied antibody brain exposure
The morADC platform aims to overcome challenges faced by existing modalities and improve clinical outcomes for patients with neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) announced that its active-immunotherapy candidate, ACI-35.030 (now called JNJ-2056), has received Fast Track designation from the FDA for Alzheimer's disease treatment. The therapy targets the pathologic form of the Tau protein, phosphorylated Tau (pTau). A Phase 2b clinical trial called ReTain is currently recruiting participants with preclinical Alzheimer's disease.
Key points:
- First active immunotherapy tested in a preclinical AD population
- Potential therapeutic advantages and benefits in convenience and access
- Shown to specifically target toxic form of Tau in Phase 1b/2a clinical testing
- Developed in partnership with Janssen Pharmaceuticals
- ReTain trial is fully funded and conducted by Janssen
AC Immune SA (NASDAQ: ACIU) will present three oral presentations at the Alzheimer's Association International Conference (AAIC 2024) in Philadelphia, showcasing its precision medicine pipeline for neurodegenerative diseases. The presentations will focus on:
1. [18F]ACI-19626, a first-in-class TDP-43-PET tracer
2. ACI-24.060, an active immunotherapy inducing anti-Abeta antibodies
3. morADC (Morphomer®-Antibody Drug Conjugates), a new class of neurodegenerative disease-fighting drugs
Additionally, a poster presentation will compare clinical endpoint progression rates in sporadic Alzheimer's disease and Down Syndrome-related Alzheimer's disease.
The clinical-stage biopharmaceutical company AC Immune (NASDAQ: ACIU) announced its participation in the Jefferies 2024 Global Healthcare Conference in New York, scheduled for June 5-6, 2024.
Company management will engage in a fireside chat on June 5 at 3:30 PM (ET), which can be accessed via webcast. Additionally, AC Immune will hold one-on-one meetings with investors. This involvement aims to highlight their precision medicine advancements for neurodegenerative diseases.
The webcast and an archived replay will be available on AC Immune’s website.
AC Immune reported its first quarter 2024 financial results and corporate update, highlighting a landmark deal with Takeda for ACI-24.060 with $100 million upfront and potential payments of up to $2.1 billion. The ACI-24.060 ABATE Phase 2 trial is on track to report results in Q2 2024, and the ACI-7104.056 VacSYn Phase 2 trial in Parkinson's disease is progressing. The company has a three-year cash runway with CHF 104.8 million. Financially, the company had a cash balance of CHF 104.8 million, R&D expenses of CHF 15.2 million, and reported a net loss of CHF 17.9 million for the quarter.
AC Immune and Takeda have signed an exclusive option and license agreement for ACI-24.060, an active immunotherapy targeting Amyloid Beta for Alzheimer's disease. Takeda will pay AC Immune $100 million upfront, with additional potential milestones totaling around $2.1 billion. AC Immune will host a conference call and webcast to discuss the agreement.
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