Welcome to our dedicated page for AC Immune news (Ticker: ACIU), a resource for investors and traders seeking the latest updates and insights on AC Immune stock.
AC Immune SA (NASDAQ: ACIU) generates frequent news flow as a clinical-stage biopharmaceutical company developing precision therapeutics and diagnostics for neurodegenerative diseases. Company updates often center on clinical trial progress for its active immunotherapies and small-molecule programs targeting misfolded proteins implicated in Alzheimer’s disease, Parkinson’s disease and other NeuroOrphan indications.
Investors following ACIU news can expect detailed reports on interim and top-line data from key studies, such as the Phase 2 VacSYn trial of ACI-7104.056 in early Parkinson’s disease and the Phase 2 ABATE and ReTain trials in Alzheimer’s disease. Recent releases have highlighted strong immunogenicity and favorable safety for ACI-7104.056, biomarker trends suggesting potential stabilization of Parkinson’s disease pathology, and peer-reviewed results for the Tau-targeting active immunotherapy ACI-35.030 published in eBioMedicine.
News items also cover AC Immune’s diagnostic imaging efforts, including preclinical and clinical updates on PET tracers like ACI-19626 for TDP-43 pathology, with data published in Nature Communications. Corporate communications frequently include quarterly financial results, cash runway disclosures, pipeline prioritization decisions, workforce adjustments, and information on collaborations with partners such as Janssen, Takeda and Lilly.
This ACIU news page aggregates these company-issued announcements and regulatory communications, giving readers a single place to review clinical milestones, scientific publications, conference presentations and strategic corporate actions. For those tracking AC Immune’s progress in precision prevention of neurodegenerative diseases, it provides an organized view of how the pipeline and partnerships are evolving over time.
AC Immune SA (NASDAQ: ACIU) revealed new interim data from its Phase 1b/2a trial for ACI-35.030, a pioneering pTau vaccine for early Alzheimer's disease. Findings show significant antibody induction specific to pathological pTau, with a favorable safety profile noted in all dosage cohorts. The study has been expanded to 24 participants to gather more data. CEO Andrea Pfeifer stated these results support ongoing late-stage development, potentially reshaping AD treatment towards earlier interventions alongside advanced diagnostics.
AC Immune SA (NASDAQ: ACIU) announced strong preclinical results for its optimized ACI-24 vaccine targeting neurotoxic pyroGlu-Abeta variants, crucial in Alzheimer's disease. The data, published in Brain Communications, highlights ACI-24's robust immune response in non-human primates and mice, outperforming other tested vaccines. The company plans to advance ACI-24 into clinical development for Alzheimer's and Down syndrome-related Alzheimer's disease in 2022. AC Immune is positioned as a leader in developing active vaccines for neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU), a leader in precision medicine for neurodegenerative diseases, will participate in the SVB Leerink 11th Annual Global Healthcare Conference from February 14-18, 2022. CEO Prof. Andrea Pfeifer will engage in a fireside chat on February 16 at 8:00 am ET, discussing the company’s strategic plans and seven upcoming clinical readouts. The event will be available via webcast on their website. AC Immune is advancing a robust pipeline with ten therapeutic and three diagnostic candidates, focusing on diseases like Alzheimer’s and Parkinson’s.
AC Immune SA (NASDAQ: ACIU) has received approximately USD 1.5 million in grants from The Michael J. Fox Foundation for Parkinson’s Research. This funding will support the development of innovative small molecules aimed at inhibiting alpha-synuclein (a-syn) aggregation and NLRP3 inflammasome activation in Parkinson’s disease. The grants enhance AC Immune's research capabilities and expand its portfolio, including an anti-a-syn vaccine and a novel imaging tracer, showcasing its commitment to precision medicine in treating neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) presented promising interim Phase 1b/2a trial results for ACI-35.030, a vaccine targeting pathological tau in Alzheimer's disease, at the 14th CTAD conference. The data shows significant antibody induction against pTau and its aggregated forms, indicating strong immunogenicity. Safety data revealed no clinically relevant concerns. The trial has expanded to 24 participants to support late-stage development. The results suggest potential for early intervention in Alzheimer's treatment, with further data expected from the ongoing study.
AC Immune announced positive topline results from its Phase 2 Lauriet study of semorinemab, an anti-Tau monoclonal antibody for mild-to-moderate Alzheimer’s disease (AD). The study achieved a 43.6% reduction in cognitive decline at week 49 as measured by the ADAS-Cog11 scale, confirming the treatment's efficacy across various subgroups. However, it did not meet the second co-primary endpoint related to daily living activities. Safety results were positive, indicating semorinemab had an acceptable safety profile with no unexpected adverse events. The ongoing open-label study aims to further assess long-term effects.
AC Immune SA (NASDAQ: ACIU) reported progress in its clinical trials and financial results for Q3 2021, achieving its first positive cognitive results for a Tau-targeting monoclonal antibody in Alzheimer’s disease. The Phase 2 Lauriet trial showed a statistically significant 43.6% reduction in cognitive decline. The company enhanced its portfolio through the acquisition of an alpha-synuclein vaccine candidate. Financially, AC Immune holds CHF 188.6 million in cash, sufficient to fund operations through Q1 2024, despite a net loss of CHF 15.9 million for the quarter.
AC Immune SA (NASDAQ: ACIU), a biopharmaceutical company based in Switzerland, is extending its research partnership with the University of Pennsylvania focused on TDP-43 proteinopathies. The collaboration aims to explore the mechanisms of TDP-43 misfolding and cell-to-cell transmission, which are important in neurodegenerative diseases like ALS and Alzheimer's. The initial research demonstrated distinct TDP-43 species affecting disease progression. AC Immune is also advancing its lead anti-TDP-43 antibody and developing a PET tracer for diagnostics.
AC Immune SA (NASDAQ: ACIU) announced the presentation of new data on its Alzheimer’s disease candidates at the upcoming Clinical Trials on Alzheimer’s Disease (C-TAD) Conference in Boston from November 9-12, 2021. Highlights include:
- Semorinemab: Phase 2 trial results presented on November 10.
- ACI-35.030: Interim Phase 1b/2a data on safety presented on November 12.
- ACI-24: Phase 2 study results from November 9-12.
This continues AC Immune's focus on neurodegenerative diseases with a pipeline of clinical candidates.
AC Immune (NASDAQ: ACIU) has appointed Dr. Monica Shaw and Prof. Monika Bütler to its Board of Directors following an extraordinary general meeting (EGM). They replace Mr. Martin Velasco and Dr. Peter Bollmann. Dr. Shaw brings extensive drug development experience, while Prof. Bütler contributes expertise in economics and public policy. Both express enthusiasm about advancing AC Immune's mission in precision medicine for neurodegenerative diseases like Alzheimer’s. The company has a strong pipeline and partnerships that may enhance shareholder value.
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