Adaptimmune Therapeutics Plc - ADAP STOCK NEWS

Adaptimmune Therapeutics plc (Nasdaq: ADAP) announced major developments in cancer therapies, particularly targeting MAGE-A4. The SPEARHEAD-1 trial met its primary endpoint, paving the way for a BLA submission for afami-cel by Q4 2022. The company is advancing its allogeneic platform with an IND submission planned for 2023. Revenue for 2021 reached $6.1 million, a rise attributed to increased collaboration activities. However, R&D expenses rose to $111.1 million, contributing to a net loss of $158.1 million. The company confirmed financial guidance, projecting liquidity into early 2024.

Adaptimmune Therapeutics plc (Nasdaq:ADAP) will report its financial results for Q4 and the full year ending December 31, 2021, on March 14, 2022, before U.S. markets open. The announcement will be followed by a live teleconference and webcast at 8:30 a.m. EDT (12:30 p.m. GMT). The company focuses on developing cancer immunotherapy products using its SPEAR® T-cell platform to target multiple solid tumors. Investors can access the press release and webcast on the company's investor website.

Ensemble/Mosaic and Oxford Properties Group have formed a strategic partnership to develop up to 3 million square feet of life science properties at the Navy Yard in Philadelphia. This includes an investment in five existing properties and plans for two new buildings: 1201 Normandy Place (137,000 sq ft) and 333 Rouse Boulevard (105,000 sq ft), set to commence construction in 2022. Oxford's investment will enhance its $2 billion life science portfolio across North America, driven by a growing ecosystem of educational institutions and innovative companies.

Adaptimmune Therapeutics has appointed Cintia Piccina as Chief Commercial Officer, effective January 31, 2022. Piccina brings over 20 years of experience in the biopharmaceutical industry, particularly in cell and gene therapy. Her previous roles include Head of Commercial at 2Seventy Bio and SVP at bluebird bio, where she led the launch of Abecma, the first cell therapy for multiple myeloma. This leadership change aims to bolster Adaptimmune's commercial strategies as it prepares to submit its first BLA for afami-cel and expand its MAGE-A4 franchise.

The Phase 1 SURPASS trial presented by Adaptimmune Therapeutics (Nasdaq: ADAP) highlighted the efficacy of AKT inhibitors (AKTi) in enhancing SPEAR T-cell products. The addition of AKTi during ex vivo manufacturing improved T-cell proliferation and memory phenotype, leading to better antitumor responses. Notably, ADP-A2M4CD8 SPEAR T-cells displayed higher median persistence in patients, suggesting robust immune response potential. Results from the radiation sub-study indicated a disease control rate of 100%, underscoring the promising therapeutic effects of afami-cel.

Adaptimmune Therapeutics (ADAP) announced that its SPEARHEAD-1 trial has met its primary endpoint, with an overall response rate (ORR) of 34% in patients treated with afami-cel. This data will support a Biologics License Application (BLA) filing next year. The disease control rate stands at 85%, with a favorable benefit:risk profile observed. Translational data confirm afami-cel's efficacy against MAGE-A4 expressing targets both in vitro and in vivo.

Adaptimmune Therapeutics plc (ADAP) announced a strategic collaboration with Genentech, receiving a $150 million upfront payment. The SURPASS trial data presented at ESMO shows a 36% overall response rate and an 86% disease control rate across various solid tumors. The company has initiated the Phase 2 SURPASS-2 trial for esophageal and EGJ cancers and plans to begin SURPASS-3 for ovarian cancer in 2022. Financial results reveal a net loss of $42.4 million for Q3, while cash and liquidity are sufficient to fund operations into early 2024.

Deep Genomics has appointed Tal Zaks, MD, PhD, former CMO of Moderna, to its Strategic Advisory Board. Zaks brings valuable experience from leading mRNA vaccine development, including Moderna’s COVID-19 vaccine. This move aims to bolster Deep Genomics' mission to create programmable medicines through its advanced AI Workbench platform. With a recent $180 million funding, the company plans to expand its pipeline significantly, targeting thirty AI-discovered programs by 2024, while enhancing its research capabilities in Toronto and Cambridge.

Adaptimmune Therapeutics (Nasdaq:ADAP) plans to announce its third-quarter financial results for the period ending September 30, 2021, on November 4, 2021, prior to U.S. market opening. A live teleconference and webcast will follow at 8:00 a.m. EDT. The press release and webcast will be accessible via the investor section of the company’s website. Adaptimmune is focused on developing innovative cancer immunotherapy products using its unique SPEAR T-cell platform, targeting multiple solid tumors. This announcement comes with forward-looking statements regarding potential risks and uncertainties.