Allarity Therapeutics Presents Two AACR 2026 Posters Highlighting Stenoparib’s Potential in Colorectal Cancer as well as New Predictive Data Linking DRP® and Overall Survival in Ovarian Cancer
Rhea-AI Summary
Allarity Therapeutics (NASDAQ: ALLR) presented two posters at AACR Annual Meeting 2026 (April 17–22) highlighting new data on stenoparib (2X-121).
One poster links the stenoparib DRP® to enhanced overall survival in recurrent ovarian cancer; the other shows stenoparib modulates the WNT/β-catenin pathway and inhibits colorectal cancer cell growth at clinically relevant concentrations.
Positive
- None.
Negative
- None.
News Market Reaction – ALLR
In the Apr 21 session, ALLR gained 10.40%, reflecting a significant positive market reaction. Argus tracked a peak move of +13.0% during that session. Our momentum scanner triggered 11 alerts that day, indicating notable trading interest and price volatility.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 31 | Full-year 2025 earnings | Positive | +4.8% | Reported 2025 results with clinical progress and improved financial position. |
| Mar 06 | Debt financing | Positive | +21.6% | Closed $20M non-convertible debt to fund stenoparib toward FDA approval. |
| Feb 18 | Phase 2 dosing start | Positive | +8.7% | First patients dosed in VA-funded Phase 2 SCLC trial with stenoparib combo. |
| Feb 03 | Trial enrollment open | Positive | -8.1% | VA-funded Phase 2 SCLC trial opened for enrollment across 11 VA sites. |
| Dec 31 | CEO year-end letter | Positive | +6.9% | CEO highlighted strategic refocus on stenoparib and encouraging survival data. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Positive strategic, financing, and clinical updates have usually been followed by positive one-day moves, with only one notable divergence on a clinical trial enrollment update.
Over the past six months, Allarity has focused on advancing stenoparib and strengthening its balance sheet. Key events include full-year 2025 results with FDA Fast Track designation and a $20 million debt financing, plus multiple Phase 2 trial milestones in ovarian and small cell lung cancer. Most of these updates, including the financing on Mar 6, 2026 and VA-funded trial dosing on Feb 18, 2026, were followed by positive price reactions, framing today’s AACR data within a generally constructive news trajectory.
Key Terms
parp medical
wnt pathway medical
drug response predictor (drp®) medical
companion diagnostic medical
overall survival medical
tankyrase medical
wnt/β-catenin signaling pathway medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- New AACR data highlight stenoparib’s potential in colorectal cancer through WNT pathway modulation
- The Stenoparib-DRP® companion diagnostic is associated with enhanced overall survival in Ovarian Cancer patients
- Posters now available on Allarity’s website
TARPON SPRINGS, Fla., April 21, 2026 – Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company dedicated to developing stenoparib (2X-121)—a differentiated, dual PARP and WNT pathway inhibitor— today announced that it has published two scientific posters being presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, held April 17–22 in San Diego, California. Both are now available in the Scientific Publications section of the Company’s website.
The two posters highlight new data supporting stenoparib’s differentiated mechanism of action as well as the Company’s proprietary Drug Response Predictor (DRP®) for stenoparib as a companion diagnostic platform.
Poster presentations
Poster 1
Title: A Drug Response Predictor (DRP®) is associated with enhanced overall survival in the phase 2 trial in advanced, recurrent ovarian cancer patients treated twice daily with 2X-121/stenoparib (NCT03878849)
Session Title: Biomarkers Predictive of Therapeutic Benefit 3
Session Time: April 20, 2026, 9:00 AM – 12:00 PM
This poster highlights clinical data demonstrating that the highest stenoparib DRP® scores are associated with enhanced overall survival in patients treated with stenoparib, reinforcing the value of DRP-based patient selection in ring-fencing those patients most likely to benefit from stenoparib.
Poster 2
Title: 2X-121/stenoparib - a novel, dual inhibitor of PARP and tankyrase in phase 2 clinical trials in advanced ovarian cancer - blocks the WNT signaling pathway and inhibits growth of human colorectal cancer cell lines at clinically relevant drug concentrations
Session Title: Novel Antitumor Agents 2
Session Time: April 21, 2026, 9:00 AM – 12:00 PM
This poster presents new findings demonstrating stenoparib’s unique mechanism of action to modulate the WNT/β-catenin signaling pathway and to inhibit the growth of colorectal cancer cell lines at clinically relevant concentrations. Colon and rectal cancers remain among the most prevalent and deadly cancers in the United States, with a high number of both new cases and cancer-related deaths each year, according to the National Cancer Institute, underscoring the significant unmet medical need in this indication.
Chief Executive Officer of Allarity Therapeutics, Thomas Jensen, commented:
“These new data highlight the potential for stenoparib in one of the largest areas of unmet need in oncology—colorectal cancer—where we believe stenoparib’s unique mechanism of action could make it a highly relevant therapy for this patient population. Moreover, based on insights from our ongoing stenoparib clinical development, we believe our DRP® platform may play an important role in identifying those patients most likely to achieve the outcomes we ultimately seek in cancer therapy: enhanced and extended survival with a favorable tolerability profile. It is difficult to overstate the importance of this, as extended survival- especially from an easy-to-take oral therapy without the typical toxicities of chemotherapy- addresses the most critical considerations for both patients and oncologists when selecting a particular therapy.”
Both posters are available on the Company’s website under the Scientific Publications section.
About Stenoparib/2X-121
Stenoparib is an orally available, small-molecule dual-targeted inhibitor of PARP1/2 and tankyrase 1/2. At present, tankyrases are attracting significant attention as emerging therapeutic targets for cancer, principally due to their role in regulating the WNT signaling pathway. Aberrant WNT/β-catenin signaling has been implicated in the development and progression of numerous cancers. By inhibiting PARP and blocking WNT pathway activation, stenoparib’s unique therapeutic action shows potential as a promising therapeutic for many cancer types, including ovarian cancer, Small Cell Lung Cancer and colorectal cancer. Allarity has secured exclusive global rights for the development and commercialization of stenoparib, which was originally developed by Eisai Co. Ltd. and was formerly known under the names E7449 and 2X-121. Allarity has two ongoing Phase 2 trial protocols for stenoparib in Ovarian Cancer patients. In the first, patients who had had 2+ lines of therapy were enrolled on stenoparib and given drug twice daily. This protocol has been closed to further enrollment but continues for the enrolled patients who are still receiving benefit from stenoparib administration. The updated data from this study were presented at the AACR special conference on advances in Ovarian Cancer in September 2025. Note that, as these data are from an ongoing trial, analyses may change as the study fully matures. An amended protocol designed expressly to capitalize on the emerging clinical experience with stenoparib in platinum resistant patients began enrolling patients in the summer of 2025. This amended protocol enrolls only platinum resistant or platinum-ineligible patients and is designed to accelerate the clinical development of stenoparib toward FDA approval. In parallel, a separate Phase 2 trial evaluating stenoparib in combination with temozolomide for relapsed small cell lung cancer (SCLC) began enrolling patients in early 2026 and is currently enrolling patients across multiple U.S. Veterans Administration (VA) sites.
About the Drug Response Predictor – DRP® Companion Diagnostic
Allarity uses its drug-specific DRP® to select those patients who, by the gene expression signature of their cancer, may have a high likelihood of benefiting from a specific drug. By screening patients before treatment, and only treating those patients with a sufficiently high, drug-specific DRP score, the therapeutic benefit rate may be enhanced. The DRP method builds on the comparison of sensitive vs. resistant human cancer cell lines, including transcriptomic information from cell lines, combined with clinical tumor biology filters and prior clinical trial outcomes. DRP is based on messenger RNA expression profiles from patient biopsies. The DRP® platform has shown an ability to provide a statistically significant prediction of the clinical outcome from drug treatment in cancer patients across dozens of clinical studies (both retrospective and prospective). The DRP platform, which may be useful in all cancer types and is patented for dozens of anti-cancer drugs, has been extensively published in the peer-reviewed literature.
About Allarity Therapeutics
Allarity Therapeutics, Inc. (NASDAQ: ALLR) is a clinical-stage biopharmaceutical company dedicated to developing personalized cancer treatments. The Company is focused on development of stenoparib, a novel PARP/tankyrase inhibitor for advanced ovarian cancer patients, using its DRP® technology to develop a companion diagnostic that can be used to select those patients expected to derive the greatest clinical benefit from stenoparib. Allarity is headquartered in the U.S., with a research facility in Denmark, and is committed to addressing significant unmet medical needs in cancer treatment. For more information, visit www.allarity.com.
Follow Allarity on Social Media
LinkedIn: https://www.linkedin.com/company/allaritytx/
Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements provide the Company’s current expectations or forecasts of future events. The words “anticipates,” “believe,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “might,” “plan,” “possible,” “potential,” “predicts,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include, but are not limited to, statements regarding the publication and presentation of data from the AACR 2026 Annual Meeting; the interpretation and significance of the data presented; the potential applicability of stenoparib in colorectal cancer and other cancer indications; and the potential utility of the Company’s DRP® companion diagnostic platform. Any forward-looking statements in this press release are based on management’s current expectations of future events and are subject to multiple risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, risks related to the possibility that the data presented may not be predictive of future clinical results; the risk that preclinical findings may not translate into clinical benefit; the risk that the Company’s DRP® companion diagnostic may not be successfully developed, validated, or applied in future clinical settings; and broader risks related to the Company’s clinical development, regulatory progress, and financial resources. For a discussion of other risks and uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled “Risk Factors” in our Form 10-K annual report filed with the Securities and Exchange Commission (the “SEC”) on March 30, 2026, available at the SEC’s website at www.sec.gov, and as well as discussions of potential risks, uncertainties and other important factors in the Company’s subsequent filings with the SEC. All information in this press release is as of the date of the release, and the Company undertakes no duty to update this information unless required by law.
###
Company Contact:
investorrelations@allarity.com
Media Contact:
Thomas Pedersen
Carrotize PR & Communications
+45 6062 9390
tsp@carrotize.com
Attachment
