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Aileron Therapeutics (NASDAQ: ALRN) provided a business update on January 5, 2022, focusing on its clinical trial plans for its chemoprotective agent ALRN-6924. The company aims to initiate a Phase 1b trial in neoadjuvant breast cancer by 1H22, with interim data expected in 4Q22. Aileron also anticipates interim results from an ongoing NSCLC trial in 2Q22 and topline results in 4Q22. In 2021, Aileron secured 11 new patents, enhancing its intellectual property portfolio to over 170 patents globally, reinforcing its commitment to developing safer chemotherapy alternatives.
Aileron Therapeutics (Nasdaq: ALRN) announced that Dr. Manuel Aivado will present a company overview at two upcoming virtual conferences: the H.C. Wainwright BIOCONNECT Conference from January 10-12, 2022, and the Emerging Growth Conference on January 5, 2022. The H.C. Wainwright presentation will be available on-demand starting January 10 at 7:00 a.m. ET. Aileron's ALRN-6924 is a first-in-class chemoprotective agent targeting p53-mutated cancers, aiming to improve chemotherapy tolerability while preserving healthy cells.
Aileron Therapeutics (NASDAQ:ALRN) expressed deep sorrow over the passing of Nobel Laureate Robert H. Grubbs, Ph.D., a member of its Scientific Advisory Board since 2011. Grubbs, a prominent chemist, significantly influenced Aileron's stapled peptide technology and the chemoprotective agent ALRN-6924.
His contributions to metathesis reactions enabled the development of specialized drugs and plastics. Aileron vows to honor his legacy by advancing ALRN-6924, aimed at improving the chemotherapy experience for patients with p53-mutated cancers.
Aileron Therapeutics (NASDAQ:ALRN) continues its Phase 1b trial of ALRN-6924 for p53-mutated non-small cell lung cancer (NSCLC). Planned data readouts include interim results in 2Q22 and topline results in 4Q22. As of September 30, 2021, the company reported $52.2 million in cash, expected to fund operations until mid-2023. R&D expenses rose to $4.3 million, while net loss increased to $6.7 million. ALRN-6924 aims to protect healthy cells from chemotherapy-induced side effects, potentially addressing a critical need for cancer patients.
Aileron Therapeutics has presented new preclinical data at the AACR-NCI-EORTC conference, highlighting ALRN-6924's potential as a chemoprotective and radioprotective agent for patients with p53-mutated cancers undergoing chemotherapy. The data shows that ALRN-6924 activates p21, which may help protect healthy cells from chemotherapy and radiation-induced toxicities. The company is currently conducting a Phase 1b clinical trial in patients with advanced non-small cell lung cancer, aiming to reduce chemotherapy side effects while maintaining efficacy.
Aileron Therapeutics (ALRN) announced new preclinical data on its investigational drug ALRN-6924, showcasing its potential as a radioprotective agent against radiation-induced toxicities. ALRN-6924, a first-in-class MDM2/MDMX dual inhibitor, aims to protect healthy cells during chemotherapy for patients with p53-mutated cancers. The data will be presented at the AACR-NCI-EORTC conference on October 7, 2021. The Phase 1b trial for ALRN-6924 is underway, evaluating its effectiveness in non-small cell lung cancer patients treated with carboplatin and pemetrexed.
Aileron Therapeutics (ALRN) announced positive outcomes from its Phase 1b trial of ALRN-6924 in small cell lung cancer (SCLC) patients receiving topotecan, showing significant reductions in chemotherapy-induced neutropenia, thrombocytopenia, and anemia compared to historical controls. Preliminary findings from a Phase 1 pharmacology study confirmed the optimal dose of ALRN-6924 at 0.3 mg/kg, demonstrating its pharmacodynamic effects. These results inform future studies of ALRN-6924 as a chemoprotective agent across various p53-mutated cancers.
Aileron Therapeutics (Nasdaq: ALRN) announced its upcoming presentations at the ESMO Virtual Congress 2021, including preliminary data from a Phase 1 study of ALRN-6924 in healthy volunteers and final results from a Phase 1b study in patients with small cell lung cancer (SCLC) receiving topotecan. ALRN-6924 aims to protect healthy cells from chemotherapy-induced side effects while targeting cancer cells. The findings support ongoing and future studies in patients with p53-mutated cancers.
Aileron Therapeutics (Nasdaq: ALRN) announced that CEO Manuel Aivado will present at the H.C. Wainwright Virtual Global Investment Conference from September 13-15, 2021. His presentation will cover the progress of ALRN-6924, a selective chemoprotective agent targeting p53-mutated cancers. The on-demand presentation will be available to registered attendees starting September 13, 2021, at 7 AM ET and accessible for 30 days on Aileron's website. Aileron aims to enhance chemotherapy tolerability and improve patients' quality of life by protecting healthy cells during treatment.
Aileron Therapeutics (Nasdaq: ALRN) reported initial findings from its study of ALRN-6924, showcasing that a 0.3 mg/kg dose was well tolerated and induced p53-mediated p21 in normal bone marrow cells. This Phase 1b trial aims to evaluate ALRN-6924 as a chemoprotective agent for patients with advanced p53-mutated non-small cell lung cancer (NSCLC). Nearly 1 million patients in the U.S. are diagnosed yearly with p53-mutated cancers. Aileron also plans to present more data from this study at the upcoming ESMO Congress in September 2021.
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