Altimmune to Present Phase 2b IMPACT Data on Pemvidutide in MASH in Late-Breaking Oral Podium Presentation and Late-Breaking Poster at AASLD The Liver Meeting® 2025

Rhea-AI Summary

Altimmune (Nasdaq: ALT) will present 24-week Phase 2b IMPACT data for pemvidutide in metabolic dysfunction-associated steatohepatitis (MASH) at AASLD The Liver Meeting® 2025 in Washington, D.C., Nov 7–11, 2025.

Two late-breaking presentations are scheduled: an oral podium on Nov 11, 2025 at 11:45 a.m. ET by Dr. Mazen Noureddin covering the randomized, placebo-controlled trial (publication 5001), and a late-breaking poster on Nov 8, 2025 from 1:00–2:00 p.m. ET by Dr. Julio Gutierrez showing AI-based digital pathology analysis of liver fibrosis (publication 5025). The company expects to announce 48-week data in Q4 2025 and will post the presentation and poster on its Events page.

Insights

Clinical Trial & Corporate Impact Analyst

Late‑breaking 24‑week Phase 2b data presentations for pemvidutide are scheduled at AASLD Nov 7–11, 2025; 48‑week data expected in Q4 2025.

The company advances a mid‑stage efficacy and safety data set into major scientific forums, which formally communicates clinical outcomes to clinicians, regulators, and trial sites. Presenting both an oral late‑breaking abstract and a poster that includes AI‑based digital pathology shows focus on measurable endpoints for liver fibrosis and broader engagement with the hepatology community.

Key dependencies and risks include the actual direction and magnitude of the 24‑week results (not stated here), peer reception at the meeting, and the forthcoming 48‑week data report in Q4 2025. If the 24‑week readout lacks clear efficacy or raises safety concerns, scientific scrutiny could weigh on perception; conversely, robust fibrosis reduction would drive clinical interest. Monitor the oral presentation on Nov 11, 2025 and the poster session on Nov 8, 2025 for concrete endpoint data and any adverse event summaries within the presentation materials.

Oral presentation to highlight 24-week efficacy and safety data

Poster to feature results of AI-based analyses of liver fibrosis reduction

GAITHERSBURG, Md., Oct. 20, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing novel peptide-based therapeutics for liver and cardiometabolic diseases, today announced that 24-week data from its Phase 2b IMPACT trial of pemvidutide in metabolic dysfunction-associated steatohepatitis (MASH) will be presented in late-breaking oral and poster presentations at The Liver Meeting^® 2025, hosted by the American Association for the Study of Liver Diseases (AASLD) in Washington, D.C., November 7–11, 2025.

Details of the presentations are as follows:

Poster Presentation Details

• Abstract Title: Reduction of Liver Fibrosis by AI-Based Digital Pathology Analysis: Results from the Pemvidutide Phase 2 IMPACT Trial
• Session: Saturday Late-Breaking Posters (publication number 5025)
• Date/Time: The presenter will present/take questions during Poster Session II on Saturday, November 8, 2025 from 1:00 – 2:00 p.m. ET. The poster will be on display throughout The Liver Meeting^®
• Presenter: Dr. Julio Gutierrez, Transplant Hepatologist at the Scripps Organ and Cell Transplant Program and Senior Medical Director at Altimmune

Oral Presentation Details

• Abstract Title: A Phase 2, Multicenter, Randomized, Placebo-Controlled Trial of Pemvidutide in Metabolic Dysfunction-Associated Steatohepatitis
• Session: Late-Breaking Abstracts Parallel Session 3 (publication number 5001)
• Date/Time: Tuesday, November 11, 2025 at 11:45 a.m. ET
• Presenter: Dr. Mazen Noureddin, Professor of Medicine at the Houston Methodist Hospital and Co-Chairman of the Board for Summit and Pinnacle Clinical Research

The AASLD late-breaking presentations will focus on the recent IMPACT Phase 2b readout of the 24-week data. In addition, Altimmune expects to announce 48-week data in Q4 2025.

A copy of the presentation and poster will be accessible on the Events section of the Altimmune website.

About the Phase 2b IMPACT Study

The IMPACT (NCT05989711) trial enrolled 212 participants with biopsy-confirmed MASH and fibrosis stages F2/F3 with and without diabetes randomized 1:2:2 to receive weekly subcutaneous pemvidutide doses at either 1.2 mg, 1.8 mg, or placebo for 24 weeks. Key efficacy endpoints were MASH resolution without worsening of fibrosis, or fibrosis improvement without worsening of MASH at 24 weeks. Secondary endpoints included weight loss and non-invasive tests of fibrosis. Participants will receive a total of 48 weeks of treatment, and a final readout is anticipated in the fourth quarter of 2025.

About Pemvidutide

Pemvidutide is a novel, investigational, peptide-based 1:1 GLP-1/glucagon dual receptor agonist in development for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH), Alcohol Use Disorder (AUD), and Alcohol-Associated Liver Disease (ALD). The combined activation of GLP-1 and glucagon receptors results in appetite suppression, weight loss, and direct effects on the liver, including reductions in liver fat, inflammation and fibrosis. The FDA granted Fast Track designations to pemvidutide for the treatment of MASH and AUD, both areas of significant unmet medical need. The 48-week readout from the ongoing IMPACT Phase 2b MASH trial is expected in Q4 2025. Phase 2 trials in AUD (RECLAIM) and ALD (RESTORE) were initiated in May 2025 and July 2025, respectively and are currently ongoing.

About Altimmune

Altimmune is a late clinical-stage biopharmaceutical company focused on developing novel peptide-based therapeutics for liver and cardiometabolic diseases. The Company’s lead product candidate is pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of MASH, Alcohol Use Disorder (AUD), Alcohol-associated Liver Disease (ALD) and obesity. For more information, please visit www.altimmune.com.

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Investor Contact:
Lee Roth
Burns McClellan
Phone: 646-382-3403
lroth@burnsmc.com

Media Contact:
Elliot Fox
Real Chemistry
efox@realchemistry.com

This press release was published by a CLEAR® Verified individual.

FAQ

When will Altimmune (ALT) present pemvidutide Phase 2b 24-week data at AASLD 2025?

Altimmune will present 24-week IMPACT data during late-breaking sessions at AASLD The Liver Meeting® 2025, Nov 7–11, 2025; the oral presentation is on Nov 11, 2025 at 11:45 a.m. ET.

Who is presenting the late-breaking oral pemvidutide data for ALT at AASLD 2025?

The oral presentation on Nov 11, 2025 at 11:45 a.m. ET will be presented by Dr. Mazen Noureddin (publication number 5001).

What will the ALT poster at AASLD 2025 show and when is it presented?

The late-breaking poster (publication 5025) presents AI-based digital pathology analysis of liver fibrosis from the pemvidutide Phase 2 IMPACT trial and will be presented during Poster Session II on Nov 8, 2025 from 1:00–2:00 p.m. ET.

Will Altimmune provide additional pemvidutide data beyond the 24-week readout?

Yes, Altimmune expects to announce 48-week data in Q4 2025.

Where can investors access Altimmune's pemvidutide presentation and poster after AASLD?

A copy of the presentation and poster will be accessible on the Events section of Altimmune's website.

What specific endpoints will Altimmune highlight in the AASLD late-breaking presentations for ALT pemvidutide?

The presentations will focus on the 24-week efficacy and safety data and AI-based analyses of liver fibrosis from the IMPACT Phase 2b trial.