Altimmune, Inc. develops pemvidutide, a late clinical-stage dual-action therapy targeting glucagon and GLP-1 receptors for serious liver diseases. Company news centers on pemvidutide development in metabolic dysfunction-associated steatohepatitis (MASH), alcohol use disorder (AUD) and alcohol-associated liver disease (ALD), including clinical trial updates and FDA designations such as Fast Track and Breakthrough Therapy Designation where granted.
Altimmune updates also cover financial results, business updates, investor conference participation and capital actions used to fund development activity. Recurring financing news includes public offerings, registered direct offerings, common stock, pre-funded warrants and common stock warrants.
Altimmune, Inc. (Nasdaq: ALT) reported its Q3 2020 financial results, highlighting a revenue increase to $2.9 million from $0.6 million year-over-year, largely driven by U.S. government contracts. The company is advancing several investigational candidates, including AdCOVID, T-COVID, and ALT-801, with plans for clinical trials commencing this year. Research and development expenses rose to $17 million, leading to a net loss of $17.8 million, or $0.54 per share. Altimmune has secured approximately $200 million to support its pipeline initiatives.
Altimmune, Inc. (Nasdaq: ALT) announced it will release its third quarter 2020 financial results on November 10, 2020. A conference call for investors will follow at 8:30 a.m. ET on the same day, where management will discuss the financial results and provide a business update. The company, focused on developing intranasal vaccines and therapies, has a diverse pipeline including products for COVID-19, anthrax, and liver disease. For more details, investors can access the conference call via a webcast.
Altimmune, a clinical-stage biopharmaceutical company (Nasdaq: ALT), announced its participation in two upcoming virtual investor conferences. The first is the H.C. Wainwright Hepatitis B Virus Conference on October 20, 2020, at 1:30 PM EDT, which will be webcast through the company's investor relations page. The second event is the B. Riley Securities Liver Disease Symposium on October 29, 2020. Altimmune specializes in intranasal vaccines and therapies for liver diseases, including COVID-19 and hepatitis B.
Altimmune's AdCOVID, a single-dose intranasal COVID-19 vaccine, shows promising preclinical results. The comprehensive evaluation highlights AdCOVID's ability to stimulate serum neutralizing antibodies, T cell responses, and mucosal immunity in the respiratory tract. In studies with mice, AdCOVID demonstrated a median neutralization titer of 1:563, exceeding FDA's convalescent plasma standard. The company plans to file an IND and begin a Phase 1 trial in Q4 2020. AdCOVID's advantages include easy storage, broad immune activation, and potential for self-administration.
Altimmune, Inc. (Nasdaq: ALT) announced a preclinical data presentation on ALT-801, a GLP-1/glucagon receptor dual agonist, targeting NASH at the Digital International Liver Congress™ 2020. The presentation highlighted ALT-801’s superior efficacy compared to semaglutide in reducing body weight, liver fat, and fibrosis markers in a preclinical mouse model. The company is preparing to start its first human Phase 1 trial in Australia in Q4 2020, with results anticipated in spring 2021.
Altimmune, Inc. (Nasdaq: ALT) reported promising results from preclinical studies of its intranasal COVID-19 vaccine candidate, AdCOVID. The research demonstrated significant stimulation of CD4+ and CD8+ T cell responses in the lungs of mice, with a strong bias towards CD8+ T cells within 10 days post-vaccination. AdCOVID showed a 29-fold increase in mucosal IgA antibodies specific to the spike protein. The company is on track to start a Phase 1 safety and immunogenicity study in Q4 2020. The vaccine's intranasal administration could facilitate rapid distribution without cold-chain logistics.
Altimmune, Inc. (Nasdaq: ALT) announced it will report its financial results for Q2 2020 before the market opens on August 12, 2020, and will host a conference call at 8:30 am ET. The company is focused on developing intranasal vaccines and immune modulating therapies, including those for COVID-19 and liver diseases. Notable products in their pipeline include AdCOVID™, NasoShield™, and ALT-801. Investors can access the conference call via the provided webcast link.
Altimmune, Inc. (Nasdaq: ALT) has partnered with Vigene Biosciences to manufacture its intranasal COVID-19 vaccine, AdCOVID. Following encouraging pre-clinical results, Altimmune plans to initiate a Phase 1 clinical trial in Q4 2020. The collaboration aims to produce at least 100 million doses of AdCOVID in 2021. AdCOVID is designed to activate both mucosal and systemic immunity, potentially offering effective defense against SARS-CoV-2 infection and spread. The partnership leverages Vigene's viral vector expertise and state-of-the-art manufacturing capabilities.
Altimmune, Inc. (Nasdaq: ALT) announced a public offering of 4,119,564 shares of common stock and pre-funded warrants for 1,630,436 shares, raising approximately $132.2 million. The offering price was $23.00 per share and $22.9999 per warrant. Proceeds will be utilized for scaling manufacturing, advancing clinical trials of AdCOVID, and continuing the development of ALT-801 for NASH. Jefferies, Evercore ISI, and Piper Sandler managed the offering, with Roth Capital Partners as co-manager. The securities were offered under a Form S-3 shelf registration.
Altimmune, Inc. (Nasdaq: ALT) announced a public offering of 3,369,564 shares of its common stock at $23.00 per share, along with pre-funded warrants to purchase 1,630,436 shares at $22.999 each. The offering is expected to generate gross proceeds of $115 million, closing around July 16, 2020. Funds will support manufacturing and clinical trials for AdCOVID, an intranasal COVID-19 vaccine, and ALT-801, for treating NASH. The underwriters have a 30-day option to purchase an additional 750,000 shares.