Angle Plc Stock Price, News & Analysis

ANGLE has achieved a groundbreaking milestone by securing FDA De Novo clearance for its Parsortix system, designed to harvest cancer cells from the blood of metastatic breast cancer patients. This marks the first FDA clearance for a product that extracts intact cancer cells, potentially transforming personalized cancer care. The clearance, earned after over six years of research and extensive clinical testing, positions ANGLE favorably in the growing liquid biopsy market, projected to exceed $100 billion annually in the U.S. alone.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) announced funding approval from Prostate Cancer UK for a clinical study at Barts Cancer Institute to assess the Parsortix system's effectiveness in predicting prostate cancer progression. The £750,000 grant will support a five-year study involving 200 men facing radical prostatectomy. The trial aims to determine if circulating tumor cells (CTCs) can forecast cancer spread, potentially establishing a new standard of care in prostate cancer treatment. This innovative approach could enhance treatment decision-making, reducing unnecessary surgeries and improving patient outcomes.

ANGLE plc (AIM:AG)(OTCQX:ANPCY) reported preliminary results for the year ending December 31, 2021, highlighting progress on FDA reviews and clinical studies. Revenue increased to £1.0 million, up from £0.8 million in 2020, while losses rose to £15.0 million due to planned investments. Key developments included the launch of clinical laboratories in the UK and US, and completion of patient enrollment in an ovarian cancer study. Cash and equivalents stood at £31.8 million. The company anticipates a regulatory response from the FDA and expects to resume ovarian cancer study analysis soon.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY), a leader in liquid biopsy technology, will release its preliminary results for the year ending December 31, 2021, on April 28, 2022. An analyst meeting is scheduled for 10:00 am BST at Berenberg's London office. A live webcast will be available on ANGLE's Investor Centre page, with a recording accessible later. ANGLE's technology includes the Parsortix system, a liquid biopsy tool designed for comprehensive cancer analysis, and has received a CE Mark in Europe, with an FDA submission underway for use in metastatic breast cancer patients.

ANGLE plc presented results from its Parsortix system at the AACR 2022 conference, showcasing its effectiveness in analyzing circulating tumor cells (CTCs) from triple negative breast cancer (TNBC) patients. The poster highlighted a higher positivity rate for CTCs compared to alternative methods, particularly noting the presence of mesenchymal phenotype CTCs and clusters. This technology supports longitudinal monitoring in cancer drug trials and is part of ANGLE's pharma services. The Parsortix system is designed for non-invasive cancer analysis and has a strong patent portfolio in multiple countries.

ANGLE plc announced results from the Molecular Oncology Laboratory at ETH Zurich, demonstrating the effectiveness of its Parsortix system in isolating circulating tumor cells (CTCs) for identifying actionable drug targets in metastatic breast cancer. The study revealed specific genes involved in metastasis, where their inhibition reduced CTC cluster formation and metastatic potential. Given that ~90% of cancer deaths are due to metastasis, this research highlights the Parsortix system's capability in advancing targeted therapies, potentially improving patient outcomes. The findings are peer-reviewed and published in Cancer Research.

ANGLE plc has announced promising research results from the University of Maryland regarding its Parsortix system for liquid biopsy. The study, focusing on triple-negative breast cancer (TNBC), demonstrated that the isolation of live circulating tumor cells (CTCs) can provide quick insights into patient responses to therapies targeting metastasis. Notably, vinorelbine treatment improved the time to cancer spread significantly. As TNBC cases continue to rise, this research could enhance treatment options and offer rapid, actionable insights for patients facing limited therapies.

ANGLE plc has announced significant findings from a study on triple negative breast cancer (TNBC) using their Parsortix system. Conducted by the Fondazione IRCCS Istituto Nazionale dei Tumori, the research shows that Parsortix can harvest intact circulating tumor cells (CTCs) for whole genome sequencing, identifying actionable genetic targets. The study revealed treatment-induced resistance and highlights the utility of CTC analysis for personalized medicine in patients with limited treatment options. The findings have been published in Scientific Reports.

ANGLE plc (AIM:AGL)(OTCQX:ANPCY) has received a Certificate of Registration from the Centers for Medicare and Medicaid Services (CMS) for its US clinical laboratory, marking a significant step towards achieving CLIA accreditation.

This accreditation will enable the laboratory to process samples for patient management across most US states. Following a CMS audit, a Certificate of Compliance will be issued. With laboratory accreditation progressing in both the US and UK, ANGLE aims to enhance its commercial offerings and support its pharma services business, as noted by Chief Medical Officer, Dr. Todd Druley.