APOLLOMICS INC - APLM STOCK NEWS

Apollomics (NASDAQ: APLM) has entered into a development and commercialization agreement with LaunXP for vebreltinib in combination with EGFR inhibitor for non-small cell lung cancer (NSCLC) treatment in Asia, excluding mainland China, Hong Kong, and Macau.

The deal includes $10 million in upfront payments to Apollomics within 60 days, potential pre-commercial milestones up to $50 million, and royalties on net product sales. LaunXP will lead the development of the combination therapy in their designated territory.

Vebreltinib, Apollomics' proprietary c-Met inhibitor, combined with EGFR inhibitor therapy aims to transform NSCLC treatment by potentially delaying resistance mutations and improving patient outcomes.

Apollomics (NASDAQ: APLM) announced disappointing top-line results from its Phase 3 bridging trial of uproleselan in China for relapsed or refractory acute myeloid leukemia patients. The trial, which enrolled 140 subjects randomized 1:1, failed to demonstrate favorable benefits when comparing uproleselan plus chemotherapy versus chemotherapy alone.

The median overall survival in the uproleselan arm was 9.3 months versus 14.3 months in the chemotherapy-only arm. While the drug was generally well-tolerated, serious adverse events occurred in 43% of uproleselan patients compared to 39% in the control group. Following these results and a previous failed global Phase 3 trial by partner Glycomimetics, Apollomics is concluding the program with expected remaining expenses under $500,000.

Apollomics (Nasdaq: APLM) has successfully regained compliance with Nasdaq's minimum bid price requirement. The company received confirmation on December 10, 2024, that its Class A Ordinary Shares maintained a closing bid price of $1.00 or higher for ten consecutive business days from November 25 to December 9, 2024. This development ensures the continued listing of Apollomics' shares on the Nasdaq Capital Market under the symbol 'APLM'. The matter is now considered closed.

Apollomics (Nasdaq: APLM) announced a 1-for-100 reverse share split of its class A ordinary shares, effective November 25, 2024. The split was approved by shareholders at the Extraordinary General Meeting on November 14, 2024. The company's shares will continue trading under 'APLM' with a new CUSIP number G0411D123. The authorized share capital will increase to 130,000,000 shares. As part of the split, warrant exercise prices will be adjusted, with public warrants' exercise price increasing to $1,150.00 from $11.50. No fractional shares will be issued.

Apollomics Inc. (Nasdaq: APLM) presented data on vebreltinib for non-small cell lung cancer (NSCLC) with METex14 skipping mutations at the ESMO Congress 2024. Key findings include:

1. Efficacy in both treatment-naïve and previously treated patients:
- Treatment-naïve: 66.7% overall response rate (ORR), 17.3 months median duration of response (DOR), 13.8 months median progression-free survival (PFS)
- Previously treated: 61.1% ORR, 16.7 months median DOR, 7.4 months median PFS

2. Efficacy regardless of MET gene copy number (GCN):
- GCN<4: 67.8% ORR
- GCN<6: 69.2% ORR
- GCN>4: 100% ORR (5/5 patients)

3. Safety profile: 48.1% of patients experienced grade 3 or higher treatment-related adverse events, with edema being most common (16.7%). No deaths were reported due to treatment-emergent adverse events.

Apollomics Inc. (Nasdaq: APLM), a late-stage clinical biopharmaceutical company, has announced its participation in the H.C. Wainwright 26th Annual Global Investment Conference. The event will take place from September 9-11, 2024, both virtually and in-person at the Lotte New York Palace Hotel in New York, NY.

Key details of Apollomics' participation include:

• An on-demand company presentation available from September 9, 2024, at 7:00 am ET
• Presenters: Guo-Liang Yu, PhD (Chairman and CEO) and Matthew Plunkett, PhD (CFO)
• Management will be available for virtual one-on-one meetings
• The presentation will be accessible on the company's website

Apollomics focuses on developing oncology drug candidates for difficult-to-treat and treatment-resistant cancers.

Apollomics Inc. (Nasdaq: APLM) reported its first half 2024 financial results and clinical progress for vebreltinib. Key highlights include:

1. Promising preliminary results from the vebreltinib program for tumors with Met dysregulation, including non-CNS MET fusion tumors and NSCLC with MET amplification.

2. Cash position of $25.9 million as of June 30, 2024, with runway into Q3 2025.

3. R&D expenses of $16.9 million and G&A expenses of $10.2 million for H1 2024.

4. Net loss of $(35.2) million, or $(0.38) per share, including a $10 million impairment loss for uproleselan.

5. Strategic focus on vebreltinib for NSCLC patients with Met Amplification.

6. Raised $5.8 million in a PIPE financing in May 2024.

Apollomics Inc. (Nasdaq: APLM) announced positive preliminary data from its Phase 2 SPARTA trial of vebreltinib in patients with non-CNS MET fusion solid tumors. The study showed a 43% overall response rate, with six confirmed responses out of 14 patients. Key highlights include:

- One complete response in metastatic non-small cell lung cancer (NSCLC)
- Five partial responses across NSCLC, pancreatic cancer, and intrahepatic bile duct cancer
- Median overall survival of 12.4 months
- Median progression-free survival of 4.5 months
- Median duration of response of 5.6 months
- Longest ongoing response of 18 months

The company believes these results support vebreltinib's potential as a targeted therapy for tumors with MET alterations, which occur in 0.1-0.3% of solid tumors.

Apollomics Inc. (Nasdaq: APLM), a late-stage clinical biopharmaceutical company focusing on oncology drug candidates for difficult-to-treat and treatment-resistant cancers, has announced its participation in the Canaccord Genuity 44th Annual Growth Conference. The event is scheduled for August 13-15, 2024, in Boston, MA.

Key details of Apollomics' presentation:

• Date and Time: Tuesday, August 14, 2024, at 9:30 am ET
• Location: InterContinental Boston Hotel
• Presenter: Matthew Plunkett, PhD, Chief Financial Officer

The company management will be available for one-on-one meetings during the conference. Interested investors can contact their Canaccord Genuity representative to schedule meetings. A webcast link for the presentation will be available on the company's website under the Investors section on the Events page.