Welcome to our dedicated page for Apellis Pharmace news (Ticker: APLS), a resource for investors and traders seeking the latest updates and insights on Apellis Pharmace stock.
Apellis Pharmaceuticals, Inc. (Nasdaq: APLS) generates frequent news as a commercial-stage biopharmaceutical company focused on C3 complement science. Its updates often center on the performance and expansion of its approved C3-targeting medicines, SYFOVRE for geographic atrophy (GA) secondary to age-related macular degeneration and EMPAVELI/Aspaveli for complement-mediated rare diseases such as C3 glomerulopathy (C3G), primary IC-MPGN, and paroxysmal nocturnal hemoglobinuria (PNH).
Investors following APLS news can expect regular disclosures on commercial execution, including U.S. net product revenues, patient start forms, market share in GA, and payer coverage trends in C3G and primary IC-MPGN. Apellis also issues news on long-term clinical data, such as five-year GALE extension results for SYFOVRE and one-year VALIANT data for EMPAVELI, which highlight durability of treatment effect and safety profiles.
Another major category of Apellis news involves clinical and regulatory milestones. Releases cover Phase 2 and Phase 3 trial progress, pivotal trial initiations in new nephrology indications like focal segmental glomerulosclerosis and delayed graft function, regulatory approvals, and opinion timelines from agencies such as the U.S. Food and Drug Administration and the European Medicines Agency. The company also announces publication of key data in peer-reviewed journals, including The New England Journal of Medicine.
Corporate and financial communications are a further news stream, including quarterly financial results, cash and cash equivalents updates, royalty and collaboration agreements with partners such as Sobi, and participation in major healthcare and investor conferences. For readers tracking APLS, this news page provides a centralized view of Apellis’ commercial performance, pipeline evolution, regulatory events, and strategic transactions related to its complement-based therapies.
Apellis Pharmaceuticals (Nasdaq: APLS) announced that the FDA accepted its unsolicited amendment to the New Drug Application (NDA) for intravitreal pegcetacoplan, aimed at treating geographic atrophy (GA) due to age-related macular degeneration (AMD). The new PDUFA goal date is set for February 26, 2023. The FDA also stated no advisory committee meeting will occur. The 24-month clinical data from Phase 3 studies DERBY and OAKS was included, suggesting a strong product profile with efficacy and safety. Apellis plans to submit an EU marketing application by the end of 2022.
Apellis Pharmaceuticals (APLS) reported Q3 2022 net product revenues of $17.7 million from EMPAVELI, contributing to total revenues of $22.1 million. The company plans to submit 24-month Phase 3 efficacy data for intravitreal pegcetacoplan for geographic atrophy (GA) to the FDA, with a PDUFA target action date set for February 2023. Cash and investments reached $708.6 million, providing a strong cash runway into Q1 2024. R&D expenses increased to $95.2 million. Despite a net loss of $191.3 million, Apellis continues to advance its product pipeline.
On November 4, 2022, Apellis Pharmaceuticals (Nasdaq: APLS) announced the approval of equity awards for 7 new employees as part of their 2022 Inducement Stock Incentive Plan. A total of 20,375 restricted stock units (RSUs) were granted, with 25% vesting after one year and the remainder vesting annually, dependent on continued employment. This initiative aligns with Nasdaq Listing Rule 5635(c)(4) and supports the company's growth strategy in the biopharmaceutical sector.
Apellis Pharmaceuticals (APLS) has announced plans to submit 24-month efficacy data from the Phase 3 DERBY and OAKS studies as part of its New Drug Application (NDA) for intravitreal pegcetacoplan, targeting geographic atrophy (GA) related to age-related macular degeneration (AMD). This submission will be a Major Amendment, extending the review period by three months with a new PDUFA target action date of February 2023. The company anticipates that these long-term data will strengthen the product profile at launch with minimal impact on the launch timeline originally scheduled for January.
Apellis Pharmaceuticals announced positive results from its long-term extension study of EMPAVELI (pegcetacoplan) for treating adults with paroxysmal nocturnal hemoglobinuria (PNH). The study, to be presented at the ASH Annual Meeting on Dec. 10, shows sustained improvements over two years, with mean hemoglobin levels at 11.6 g/dl, 83% of patients transfusion-free, and 73% achieving normalized lactate dehydrogenase levels. The therapy demonstrated efficacy in both treatment-naïve and previously treated patients, with no new safety concerns reported.
Apellis Pharmaceuticals (APLS) has announced a conference call scheduled for November 7, 2022, at 4:30 p.m. ET to discuss its third quarter 2022 financial results. The live call will be accessible via phone and through a webcast available on the company's website. The firm is recognized for pioneering the first new class of complement medicine in 15 years, aiming to develop transformative therapies for rare, retinal, and neurological diseases. Further information on the event and the company can be found on their official website.
Apellis Pharmaceuticals (Nasdaq: APLS) has granted equity awards to 8 new employees as equity inducement awards under the 2022 Inducement Stock Incentive Plan. The awards were approved on October 3, 2022, in compliance with Nasdaq Listing Rule 5635(c)(4). Each employee received options to purchase 38,840 restricted stock units (RSUs), which will vest annually over four years, contingent on continued employment. This move is part of Apellis' strategy to attract talent and enhance its strong position in the biopharmaceutical industry, particularly in complement medicine.
Apellis Pharmaceuticals announced promising results from the 24-month Phase 3 OAKS study of pegcetacoplan for treating geographic atrophy (GA) related to age-related macular degeneration (AMD). New analyses revealed that patients receiving pegcetacoplan treatments, both monthly and every-other-month, exhibited improved visual function near GA lesion borders compared to sham treatments. The data supports pegcetacoplan's potential as the first effective therapy for GA, aiming for regulatory submissions to the European Medicines Agency and a PDUFA target action date of November 26, 2022, in the U.S.
Apellis Pharmaceuticals (APLS) announced four oral presentations at the AAO Annual Meeting regarding pegcetacoplan for treating geographic atrophy (GA) due to age-related macular degeneration. The presentations will cover 24-month safety and efficacy results from Phase 3 DERBY and OAKS studies. The FDA has granted Priority Review for pegcetacoplan, with a target action date of November 26, 2022. The company plans to submit a marketing authorization application to the European Medicines Agency by year-end.
Apellis Pharmaceuticals (Nasdaq: APLS) announced an updated timing for its fireside chat at the Bank of America Global Healthcare Conference. The chat is scheduled for September 16, 2022, at 9:55 a.m. BST / 4:55 a.m. ET. This event will be accessible via a live webcast on the company's website. Apellis is recognized for its innovative work in complement medicine, having introduced the first targeted C3 therapy in 15 years to treat rare, retinal, and neurological diseases.