Arcutis Announces Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update
Rhea-AI Summary
Arcutis (Nasdaq: ARQT) reported strong commercial momentum for ZORYVE with Q4 2025 net product revenue of $127.5M (up 84% YoY, +29% sequential) and full-year 2025 net product revenue of $372.1M (up 123% YoY). The company generated $26.2M operating cash flow in Q4, raised 2026 net product sales guidance to $480–$495M, and expects an sNDA submission for ZORYVE cream 0.05% in infants in Q2 2026.
Arcutis also expanded its dermatology sales force, secured broader Medicare access, and holds cash and marketable securities of $221.3M as of Dec 31, 2025.
Positive
- Q4 ZORYVE net product revenue of $127.5M (+84% YoY)
- Full-year ZORYVE net product revenue $372.1M (+123% YoY)
- $26.2M operating cash flow in Q4 2025
- Raised 2026 net product sales guidance to $480–$495M
- sNDA accepted with PDUFA date June 29, 2026
Negative
- SG&A increased to $274.6M in 2025 (+20% YoY)
- Full-year net loss of $16.1M for 2025 remains a loss
- Other revenue declined from $30.0M (2024) to $4.0M (2025)
- Cash and marketable securities down to $221.3M from $228.6M
Market Reaction – ARQT
Following this news, ARQT has gained 9.22%, reflecting a notable positive market reaction. Our momentum scanner has triggered 6 alerts so far, indicating moderate trading interest and price volatility. The stock is currently trading at $29.50. This price movement has added approximately $279M to the company's valuation.
Data tracked by StockTitan Argus (15 min delayed). Upgrade to Silver for real-time data.
Key Figures
Market Reality Check
Peers on Argus
ARQT was up 2.55% while momentum peers like BEAM (-8.36%) and TVTX (-5.08%) moved lower, indicating a stock-specific reaction rather than a sector-wide move.
Previous Earnings Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Oct 28 | Q3 2025 earnings | Positive | +27.0% | Strong Q3 revenue growth and turn to net income with solid cash balance. |
| Aug 06 | Q2 2025 earnings | Positive | -8.1% | Robust revenue growth and reduced net loss alongside key regulatory wins. |
| May 06 | Q1 2025 earnings | Positive | -4.3% | High ZORYVE growth and broad coverage gains despite continued net loss. |
| Feb 25 | FY/Q4 2024 earnings | Positive | +8.4% | Strong Q4 revenue ramp, large full-year growth, and cash-rich balance sheet. |
| Nov 06 | Q3 2024 earnings | Positive | +7.7% | Substantial revenue acceleration and improving gross-to-net dynamics. |
Earnings have often driven sizable moves, with mostly positive reactions but some divergences when strong results did not translate into gains.
Recent history shows Arcutis using strong ZORYVE growth to improve its financial profile across multiple quarters. Prior earnings highlighted rapid revenue expansion, a shift to profitability in Q3 2025, and initial 2026 guidance of $455–$470M. Today’s update extends that trajectory with higher net product revenue, positive cash from operations, and raised 2026 guidance, building directly on the company’s prior earnings milestones.
Historical Comparison
Past earnings headlines moved ARQT by an average of 6.13%. Today’s 2.55% move is smaller than typical but directionally consistent with prior positive earnings reactions.
Earnings releases show steady ZORYVE revenue growth, improving losses into net income by Q3 2025, and progressively higher 2026 sales guidance, underscoring a multi-quarter ramp in the dermatology franchise.
Market Pulse Summary
The stock is up +9.2% following this news. A strong positive reaction aligns with Arcutis’s pattern of earnings-driven moves, where prior reports have sometimes produced double-digit gains. The combination of higher ZORYVE revenues, positive Q4 net income of $17.4M, and raised 2026 guidance to $480–$495M reinforced the existing uptrend above the 200-day MA. Investors have often rewarded this name when growth and profitability progress together.
Key Terms
phosphodiesterase-4 (pde4) inhibitor medical
atopic dermatitis medical
seborrheic dermatitis medical
vitiligo medical
hidradenitis suppurativa medical
supplemental new drug application (snda) regulatory
prescription drug user fee act (pdufa) regulatory
rule 10b5-1 trading plan financial
AI-generated analysis. Not financial advice.
- Q4 2025 net product revenue for ZORYVE® (roflumilast) was
$127.5 million , an84% increase compared to Q4 2024, and a29% increase compared to Q3 2025 - Full year 2025 net product revenue for ZORYVE was
$372.1 million , an increase of123% over the prior year - Reported positive topline data for the INTEGUMENT-INFANT Phase 2 trial of ZORYVE cream
0.05% in children ages 3 to 24 months with mild to moderate atopic dermatitis, with a Supplemental New Drug Application (sNDA) submission expected in Q2 2026 - Announced expansion of its dermatology sales force and, separately, the initiation of a targeted Arcutis commercialization effort for primary care and pediatric health care providers
- Produced positive operating cash flow in Q4 2025 and anticipates maintaining positive operating cash flow on a quarterly basis going forward
- Company raised 2026 full year net product sales guidance to
$480 million –$495 million
WESTLAKE VILLAGE, Calif., Feb. 25, 2026 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT), a commercial-stage biopharmaceutical company focused on developing meaningful innovations in immuno-dermatology, today reported financial results for the quarter and year ended December 31, 2025, and provided a business update.
“In 2025, Arcutis continued its strong performance trend, with more than
Fourth Quarter and Full Year 2025 Financial Results and Business Update
Commercial Highlights
ZORYVE—a highly potent and selective phosphodiesterase-4 (PDE4) inhibitor in once-daily cream and foam formulations, approved in the United States and Canada for the treatment of plaque psoriasis, atopic dermatitis, and seborrheic dermatitis.
- ZORYVE net product sales for the fourth quarter of 2025 were
$127.5 million , reflecting29% sequential growth over the third quarter of 2025 and84% year-over-year growth. Sequential growth was driven by increasing demand across products and improved gross-to-net (GTN) pricing. - ZORYVE net product sales for the full year of 2025 were
$372.1 million , reflecting a123% increase versus 2024. This year-over-year growth was primarily driven by increasing demand across products. - Secured Medicare access beginning in January 2026, with approximately one in three Medicare patients now having non-preferred access to ZORYVE.
- The Company launched ZORYVE cream
0.05% for the treatment of atopic dermatitis in children ages 2 to 5 years old following Food and Drug Administration (FDA) approval in early October 2025. - Announced expansion of its dermatology sales force to optimize prescriber targeting and call frequency in order to deepen adoption of ZORYVE.
- Mutually agreed to terminate the promotion agreement with Kowa in January 2026. The Company plans to assume responsibility for sales and promotion of ZORYVE in the pediatric and primary care settings with a targeted sales team.
Clinical and Regulatory Developments
- sNDA accepted for ZORYVE cream
0.3% for the treatment of plaque psoriasis down to 2 years of age with a Prescription Drug User Fee Act (PDUFA) target action date set for June 29, 2026. - Reported positive topline results for the INTEGUMENT-INFANT Phase 2 study evaluating ZORYVE cream
0.05% in infants with atopic dermatitis ages 3 to 24 months old. The Company plans to submit an sNDA for ZORYVE cream0.05% for this age group in Q2 2026. - The Company continues to enroll patients in Phase 2 proof-of-concept studies with ZORYVE foam
0.3% for the treatment of vitiligo and hidradenitis suppurativa, and expects to report decisions on program advancement in these indications in the fourth quarter of 2026 and first quarter of 2027, respectively. - The Company is preparing to enroll the first patient in a Phase 1 study of ARQ-234, a fusion protein that is a potent and highly selective checkpoint agonist of the CD200 receptor, being developed as a potential novel biologic treatment for atopic dermatitis, in Q1 2026.
Corporate Updates
- Achieved positive cash flow with
$26.2 million of cash flow from operations in Q4 2025 driven by the continued momentum of ZORYVE net sales growth combined with expense discipline. - Announced that professional golfer Max Homa, six-time PGA Tour winner, joined the Free to Be Me Awareness campaign, urging individuals with seborrheic dermatitis to tee up a conversation with their health care providers.
- Appointed Amit Munshi to the Board of Directors in December 2025 following the retirement of Bhaskar Chaudhuri.
- The Company obtained one new U.S. patent in Q4 2025 related to topical roflumilast foam compositions, extending exclusivity in the United States for our foam formulation from 2041 to 2042.
Fourth Quarter and Full Year 2025 Summary Financial Results
Total revenues for the quarter ended December 31, 2025 were
Cost of sales for the quarter ended December 31, 2025 was
Research and development (R&D) expenses for the quarter ended December 31, 2025 were
Selling, general, and administrative (SG&A) expenses for the quarter ended December 31, 2025 were
Net income was
Cash, cash equivalents, restricted cash, and marketable securities were
Financial Guidance
The Company raised net product revenue guidance for the full year 2026 from between
Conference Call and Webcast
Arcutis management will host a conference call and webcast today at 4:30 p.m. ET to discuss the financial results for the quarter and provide a business update. The webcast for this event can be accessed on the “Events” section of the Company’s website. The replay of the webcast will be available on the Arcutis website following the event.
About Arcutis
Arcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a commercial-stage medical dermatology company that champions meaningful innovation to address the urgent needs of individuals living with immune-mediated dermatological diseases and conditions. With a commitment to solving the most persistent patient challenges in dermatology, Arcutis has a growing portfolio of advanced targeted topicals approved to treat three major inflammatory skin diseases. Arcutis’ unique dermatology development platform, coupled with our dermatology expertise allows us to develop differentiated therapies against biologically validated targets, and has produced a robust pipeline for a range of inflammatory dermatological conditions. For more information, visit www.arcutis.com or follow Arcutis on LinkedIn, Facebook, Instagram and X.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. For example, statements contained in this press release regarding matters that are not historical facts are forward-looking statements. These statements are based on the Company's current beliefs and expectations. Such forward-looking statements include, but are not limited to, statements regarding the potential to address large markets with significant unmet need; the development, submission, and potential approval, and potential commercialization of product candidates and expanded indications; the potential commercial success and growth of ZORYVE in plaque psoriasis, seborrheic dermatitis, and atopic dermatitis; anticipated net product sales for 2026; the expansion of the Company's dermatology sales force and the success of the Company's efforts in primary care and pediatric health care providers; the Company's ability to maintain positive operating cash flow on a quarterly basis; the building and advancement of the Company's pipeline; and the timing of regulatory filings and potential approvals. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements and you should not place undue reliance on our forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in the clinical development process and regulatory approval process, the timing of regulatory filings, the timing, expenses, and success of our commercialization efforts, including uncertainty of future commercial sales and related items that can impact net sales, and our ability to defend our intellectual property. For a further description of the risks and uncertainties applicable to our business, see the “Risk Factors” section of our Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on February 25, 2026, as well as any subsequent filings with the SEC. Any forward-looking statements that the Company makes in this press release are made pursuant to the Private Securities Litigation Reform Act of 1995, as amended, and speak only as of the date of this press release. Except as required by law, we undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.
Contacts:
Media
Amanda Sheldon, Head of Corporate Communications
media@arcutis.com
Investors
Brian Schoelkopf, Head of Investor Relations
ir@arcutis.com
| ARCUTIS BIOTHERAPEUTICS, INC. Condensed Consolidated Balance Sheets (In thousands) (unaudited) | |||||||
| December 31, | December 31, | ||||||
| 2025 | 2024 | ||||||
| ASSETS | |||||||
| Current assets: | |||||||
| Cash and cash equivalents | $ | 42,907 | $ | 71,335 | |||
| Restricted cash | 308 | 617 | |||||
| Marketable securities | 178,075 | 156,620 | |||||
| Trade receivable, net | 146,229 | 73,066 | |||||
| Inventories | 22,634 | 14,526 | |||||
| Prepaid expenses and other current assets | 21,079 | 19,656 | |||||
| Total current assets | 411,232 | 335,820 | |||||
| Property, plant, and equipment, net | 1,043 | 1,041 | |||||
| Intangible assets, net | 14,812 | 9,479 | |||||
| Operating lease right-of-use asset | 4,467 | 1,953 | |||||
| Other assets | 1,419 | 596 | |||||
| Total assets | $ | 432,973 | $ | 348,889 | |||
| LIABILITIES AND STOCKHOLDERS’ EQUITY | |||||||
| Current liabilities: | |||||||
| Accounts payable | $ | 12,528 | $ | 14,220 | |||
| Current portion of long-term debt, net | 1,000 | — | |||||
| Accrued and other current liabilities | 116,310 | 66,793 | |||||
| Total current liabilities | 129,838 | 81,013 | |||||
| Operating lease liability, long-term | 5,266 | 2,562 | |||||
| Long-term debt, net | 107,959 | 107,203 | |||||
| Other long-term liabilities | 431 | 570 | |||||
| Total liabilities | 243,494 | 191,348 | |||||
| Stockholders’ equity: | |||||||
| Common stock | 12 | 12 | |||||
| Additional paid-in capital | 1,327,595 | 1,279,479 | |||||
| Accumulated other comprehensive loss | (44 | ) | (7 | ) | |||
| Accumulated deficit | (1,138,084 | ) | (1,121,943 | ) | |||
| Total stockholders’ equity | 189,479 | 157,541 | |||||
| Total liabilities and stockholders’ equity | $ | 432,973 | $ | 348,889 | |||
| ARCUTIS BIOTHERAPEUTICS, INC. Condensed Consolidated Statements of Operations (In thousands, except per share data) (unaudited) | |||||||||||||||
| Three Months Ended December 31, | Year Ended December 31, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Revenues: | |||||||||||||||
| Product revenue, net | $ | 127,503 | $ | 69,360 | $ | 372,072 | $ | 166,542 | |||||||
| Other revenue | 2,000 | 2,000 | 4,000 | 30,000 | |||||||||||
| Total revenues | 129,503 | 71,360 | 376,072 | 196,542 | |||||||||||
| Operating expenses: | |||||||||||||||
| Cost of sales | 11,688 | 6,905 | 36,695 | 19,128 | |||||||||||
| Research and development | 20,451 | 14,480 | 77,051 | 76,420 | |||||||||||
| Selling, general, and administrative | 78,977 | 57,607 | 274,553 | 229,391 | |||||||||||
| Total operating expenses | 111,116 | 78,992 | 388,299 | 324,939 | |||||||||||
| Income (loss) from operations | 18,387 | (7,632 | ) | (12,227 | ) | (128,397 | ) | ||||||||
| Other income (expense): | |||||||||||||||
| Interest income | 2,166 | 2,881 | 8,897 | 16,126 | |||||||||||
| Interest expense | (3,001 | ) | (5,551 | ) | (12,083 | ) | (27,168 | ) | |||||||
| Other income (expense), net | 313 | (163 | ) | 443 | 47 | ||||||||||
| Income (loss) before income taxes | 17,865 | (10,465 | ) | (14,970 | ) | (139,392 | ) | ||||||||
| Provision for income taxes | $ | 470 | $ | 323 | $ | 1,171 | $ | 647 | |||||||
| Net income (loss) | $ | 17,395 | $ | (10,788 | ) | $ | (16,141 | ) | $ | (140,039 | ) | ||||
| Earnings (loss) per share: | |||||||||||||||
| Basic | $ | 0.14 | $ | (0.09 | ) | $ | (0.13 | ) | $ | (1.16 | ) | ||||
| Diluted | $ | 0.13 | $ | (0.09 | ) | $ | (0.13 | ) | $ | (1.16 | ) | ||||
| Weighted-average shares used in computing earnings (loss) per share: | |||||||||||||||
| Basic | 128,251 | 124,919 | 127,234 | 120,958 | |||||||||||
| Diluted | 135,635 | 124,919 | 127,234 | 120,958 | |||||||||||