New Research Reveals Genomic Profile of Seborrheic Dermatitis and Answers Key Questions on Immune Response and Skin Barrier Dysfunction
Arcutis Biotherapeutics, Inc. highlights new research revealing the gene expression profile of seborrheic dermatitis, a unique inflammatory skin disease with its own molecular signature. The study suggests distinct skin barrier disruption in seborrheic dermatitis, providing key insights into the immune response of the condition.
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New research sponsored by Arcutis Biotherapeutics, Inc. unveils the gene expression profile of seborrheic dermatitis.
The study indicates unique skin barrier disruption in seborrheic dermatitis with its own disease-specific pattern.
The research sheds light on the immune response and associated skin barrier disruption of seborrheic dermatitis.
Findings suggest that seborrheic dermatitis has a distinct immunological molecular profile compared to other immune-mediated skin conditions.
The study identifies specific gene expression patterns related to immune activation and skin barrier markers in seborrheic dermatitis.
Arcutis is committed to advancing scientific understanding of seborrheic dermatitis through further research and collaboration with the dermatology community.
The discovery of a unique molecular signature for seborrheic dermatitis represents a significant advancement in the field of immuno-dermatology. The identification of 1,374 differentially expressed genes (DEGs) between affected individuals and healthy controls, with a notable upregulation of Th17 and Th22 pathways, suggests potential new targets for therapeutic intervention. The correlation between Investigator's Global Assessment (IGA) scores and immune markers provides a quantifiable measure that could improve the precision of treatment efficacy evaluations. Moreover, the reported downregulation of skin barrier markers like CLDN1/8 underscores the importance of maintaining skin integrity in managing the disease. This research could pave the way for Arcutis Biotherapeutics to develop novel treatments that address the specific pathophysiology of seborrheic dermatitis, which may have been inadequately served by therapies designed for other inflammatory skin conditions such as psoriasis or atopic dermatitis.
Understanding the molecular underpinnings of seborrheic dermatitis opens new avenues for targeted treatments that could significantly improve patient outcomes. The emphasis on Th17 and Th22-related pathways, which differ from those commonly associated with atopic dermatitis and psoriasis, highlights the unique inflammatory nature of the condition. The downregulation of tight junction proteins and lipid metabolism genes is particularly noteworthy, as it suggests that therapeutic strategies might need to focus not only on controlling inflammation but also on restoring the skin barrier function. This could lead to the development of specialized topicals or systemic treatments that specifically enhance barrier integrity and correct the lipid metabolism defects associated with seborrheic dermatitis.
This research underpins the potential for Arcutis Biotherapeutics to carve out a niche in the competitive landscape of dermatological treatments. As seborrheic dermatitis is a common condition with limited targeted treatment options, the company's focus on this disease could lead to an increased market share and generate interest among investors. The noninvasive tape-stripping technique for transcriptome analysis could also be seen as a methodological innovation, reducing patient discomfort and potentially accelerating the clinical research process. The collaboration with renowned institutions like Mount Sinai may enhance the credibility of the findings and could facilitate future partnerships or funding opportunities. However, it's important to monitor subsequent clinical trials and regulatory approval processes, as these will be the ultimate test of the research's commercial viability.
03/09/2024 - 04:00 PM
Findings show that seborrheic dermatitis is a unique inflammatory skin disease with its own molecular signature Suggests skin barrier disruption in seborrheic dermatitis is distinct with its own disease-specific pattern SAN DIEGO, Calif., March 09, 2024 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc.
“Our research group has had a longstanding interest in defining the immunological pathways that underlie many inflammatory skin diseases, such as atopic dermatitis and psoriasis, shaping our understanding of these diseases and leading to new treatments,” said Emma Guttman-Yassky, MD, PhD, the Waldman Professor of Dermatology and Immunology and Health System Chair of The Department of Dermatology, and Director of the Laboratory for Inflammatory Skin Diseases at the Icahn School of Medicine at Mount Sinai. “We are excited to have successfully employed noninvasive tape-stripping techniques developed from studying these diseases to study an understudied and undertreated inflammatory skin disease, seborrheic dermatitis. These findings will help establish the groundwork for greater understanding of this very common condition.”
“The pathophysiology of seborrheic dermatitis has been poorly understood. We sought to understand the gene expression patterns in seborrheic dermatitis in order to determine if this profile is distinct from or similar to other immune-mediated skin conditions,” said Benjamin Ungar, MD, director of the Alopecia Center of Excellence and director of the Rosacea & Seborrheic Dermatitis Clinic at Mount Sinai Health System. “Our data reveal that seborrheic dermatitis has a distinct immunological molecular profile. In addition, the skin barrier disruption observed in seborrheic dermatitis has unique molecular underpinnings, primarily in the tight junction of the epithelial skin cells and lipid metabolism pathways. These findings are the first to characterize the molecular profile of seborrheic dermatitis, and they will play an important role in advancing our understanding of this common and under-treated condition.” Dr. Ungar is also an assistant professor of Dermatology at the Icahn School of Medicine at Mount Sinai.
The data reported at AAD are from an observational study in which tape-strips were collected from facial lesions from 27 untreated patients with seborrheic dermatitis (Investigator’s Global Assessment score mild [IGA 2, n=400], moderate [IGA 3, n=19], severe [IGA 4, n=4]) and the facial skin of 18 healthy controls and analyzed with RNA sequencing (RNA-seq). Tape-strips are a non-invasive alternative to biopsy for transcriptome analysis and expression profiling.
These data demonstrate that seborrheic dermatitis is an immune disease with a uniquely polarized profile distinct from atopic dermatitis and plaque psoriasis. In addition, skin barrier disruption is suggested by a downregulation of tight junction and lipid metabolism genes. Specific findings include:
1,374 differentially expressed genes (DEGs) were identified between seborrheic dermatitis and healthy controls (674 with increased expression, 700 with decreased expression). Strong and significant upregulation of Th17-related (i.e. IL23A, PI3, LL37) and Th22-related (i.e. IL22, S100A8, S100A12) pathways were detected in seborrheic dermatitis compared with controls. Seborrheic dermatitis also showed significant Th1 activation (OASL, STAT1, CXCL9) compared with controls. There was significant downregulation of skin barrier markers (CLDN1/8, FA2H, ELOVL3) in seborrheic dermatitis compared with controls. IGA positively correlated with immune markers, including Th1/IFNG, Th17/IL17A, and Th22/IL22 [r>0.3; P<0.1 for all] and negatively correlated with skin barrier markers (SMPD4, MGLL, PLA2G15 [r≤-0.38; P<0.05]). “Despite the high prevalence of seborrheic dermatitis, there has been little dedicated clinical or basic research into the underlying cause of this chronic, inflammatory skin disease for decades. Through this collaborative research effort, we have begun to shed some light on the pathways involved in the immune response and demonstrate that seborrheic dermatitis is clearly distinct from psoriasis or atopic dermatitis, which may help explain the clinical expression of the disease, and ultimately provide important insights into its management,” said Patrick Burnett, MD, PhD, FAAD, chief medical officer, Arcutis. “We are committed to advancing the scientific understanding of this disease through additional research and collaboration with the larger dermatology research and clinical community.”
Mount Sinai has received grants from Arcutis for research conducted by Dr. Ungar and Dr. Guttman. In addition, Dr. Ungar and Dr. Guttman have served as paid consultants for Arcutis.
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What is the focus of the research highlighted by Arcutis Biotherapeutics, Inc.?
The research focuses on revealing the gene expression profile of seborrheic dermatitis, providing insights into the immune response and skin barrier disruption of the condition.
Where was the research presented?
The research was presented in a scientific session at the American Academy of Dermatology (AAD) annual meeting in San Diego, California.
Who led the research on seborrheic dermatitis at The Kimberly and Eric J. Waldman Department of Dermatology?
Dr. Benjamin Ungar, director of the Alopecia Center of Excellence and director of the Rosacea & Seborrheic Dermatitis Clinic at Mount Sinai Health System, led the research.
What were the key findings related to gene expression in seborrheic dermatitis?
The study identified 1,374 differentially expressed genes (DEGs) between seborrheic dermatitis and healthy controls, showing upregulation of Th17-related and Th22-related pathways.
How did the study suggest skin barrier disruption in seborrheic dermatitis?
The study revealed downregulation of tight junction and lipid metabolism genes in seborrheic dermatitis compared to healthy controls, indicating skin barrier disruption.
