Welcome to our dedicated page for Arvinas news (Ticker: ARVN), a resource for investors and traders seeking the latest updates and insights on Arvinas stock.
Arvinas Inc operates at the forefront of targeted protein degradation, a novel therapeutic approach that generates distinct news catalysts compared to traditional drug developers. The company's PROTAC platform, which induces complete protein degradation rather than temporary inhibition, produces news around clinical trial results, regulatory milestones, and scientific presentations that demonstrate this innovative mechanism in action.
News coverage for Arvinas typically centers on clinical data releases from its oncology programs, particularly trials evaluating protein degraders in hormone-dependent cancers. Each data readout provides insights into whether targeted protein degradation delivers on its theoretical advantages over conventional inhibitors, including deeper responses, longer durability, and activity in resistant disease. These clinical updates often include pharmacodynamic data confirming actual protein degradation in patients, a unique aspect of PROTAC development that validates the mechanism alongside efficacy measures.
Regulatory developments represent another key news category, including FDA interactions, clinical trial initiations, and submission milestones. For a company pioneering a new drug class, regulatory feedback shapes both individual program trajectories and the broader acceptance of protein degradation as a viable therapeutic modality. Scientific presentations at major oncology and drug discovery conferences also generate newsworthy content, as Arvinas shares preclinical data on pipeline expansion and mechanistic insights that inform the investment thesis around PROTAC technology.
Partnership announcements and collaborations provide additional news flow, signaling both industry validation of the platform and potential revenue streams. These deals often involve major pharmaceutical companies seeking to apply targeted protein degradation to their own proprietary targets, expanding the technology's reach beyond Arvinas' wholly-owned programs. Financial results and corporate developments round out the news landscape, offering insights into cash runway, program prioritization, and strategic direction as the company advances its clinical-stage pipeline toward potential commercialization.
Arvinas (NASDAQ: ARVN) presented preclinical data showing enhanced antitumor activity when its PROTAC BCL6 degrader ARV-393 is combined with glofitamab (CD20×CD3) at ASH 2025.
Key findings: concomitant ARV-393 (3 mg/kg) + glofitamab (0.15 mg/kg) produced 81% tumor growth inhibition (TGI) and sequential dosing produced 91% TGI vs 38% and 36% for each agent alone; higher-dose ARV-393 (6 mg/kg) combinations yielded markedly higher tumor regressions (10/10 and 7/8 mice vs 5/11 and 0/11 for single agents). RNA sequencing showed CD20 upregulation and increased interferon/antigen-presentation gene expression. Arvinas plans to initiate a Phase 1 combination cohort in DLBCL in 2026.
Arvinas (Nasdaq: ARVN) announced that Chief Medical Officer Noah Berkowitz, M.D., Ph.D. and Chief Financial Officer Andrew Saik will present in a fireside chat at the Piper Sandler 37th Annual Healthcare Conference.
The presentation is scheduled for Thursday, December 4, 2025 at 11:00 a.m. ET in New York. A live audio webcast will be available on the company’s Events and Presentations web page.
Arvinas (Nasdaq: ARVN) announced multiple abstracts on vepdegestrant (ARV-471) accepted for presentation at the San Antonio Breast Cancer Symposium (SABCS), Dec 9–12, 2025 in San Antonio, TX.
Presentations include subgroup analyses from the phase 3 VERITAC-2 trial versus fulvestrant, ctDNA biomarker analyses from a phase 1/2 study, real-world ESR1 mutation prevalence after 1L therapy, an I-SPY2 endocrine optimization pilot, and a phase 1/2 trial of PF-07248144 combined with vepdegestrant. Pfizer is a development collaborator and Quantum Leap sponsors I-SPY2 EOP. Full abstracts available via the SABCS online program.
Arvinas (NASDAQ: ARVN) reported 3Q2025 results and a corporate update highlighting clinical and preclinical progress, collaboration milestones, and financial positions. Key clinical highlights include ARV-102 showing >90% PBMC LRRK2 reduction and >50% CSF reduction with brain penetration, and ARV-102 effects on distal CSF biomarkers; ARV-806 preclinical potency ~25x–40x versus competitors with >90% degradation for 7 days in models; ARV-027 demonstrated 40–60% muscle polyQ-AR reduction and functional benefit in SBMA mice. Regulatory/commercial: FDA accepted the NDA for vepdegestrant with a PDUFA date of June 5, 2026 and Arvinas/Pfizer will jointly select a commercialization partner. Cash was $787.6M at Sept 30, 2025, funding operations into H2 2028 per management.
Arvinas (NASDAQ: ARVN) will present preclinical data for its PROTAC BCL6 degrader ARV-393 in combination with glofitamab at the 2025 American Society of Hematology (ASH) Annual Meeting.
The poster (Publication No. 1520) is in Session 605: Molecular Pharmacology and Drug Resistance: Lymphoid Neoplasms: Poster I, on December 6, 2025, 5:30 PM–7:30 PM ET, at OCCC – West Halls B3–B4. The full abstract is available via the ASH online program.
Arvinas (Nasdaq: ARVN) said management will participate in two investor conferences in November 2025: Guggenheim’s 2nd Annual Healthcare Innovation Conference on Tuesday, November 11, 2025 and the Jefferies London Healthcare Conference on Tuesday, November 18, 2025.
Both presentations will offer a live audio webcast accessible via links and the company’s Events and Presentations web section.
Arvinas (Nasdaq: ARVN) will report third quarter 2025 financial results and provide a corporate update during a live webcast on Wednesday, November 5, 2025 at 8:00 a.m. ET.
Management will review the company's Q3 2025 financial results and deliver a corporate update. The live webcast is accessible under “Events and Presentations” on Arvinas' investor website and a replay will be available at www.arvinas.com after the event.
Arvinas (Nasdaq: ARVN) announced preclinical data for ARV-806, a PROTAC KRAS G12D degrader, presented Oct 24, 2025 at the AACR-NCI-EORTC conference.
Key points: picomolar in vitro KRAS G12D degradation across pancreatic, colorectal and lung lines; >25-fold greater antiproliferative potency versus clinical-stage G12D inhibitors; >40-fold higher KRAS G12D degradation potency versus a clinical-stage G12D degrader; single IV dose produced >90% KRAS G12D degradation for seven days with c-MYC suppression and BIM induction for ≥5 days; ≥30% tumor volume reductions in pancreatic, colorectal CDX and a lung PDX model. ARV-806 is in a Phase 1 trial (NCT07023731).
Arvinas (Nasdaq: ARVN) will present preclinical data for ARV-806, a PROTAC KRAS G12D degrader, at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.
The data will be shown as Poster B107 in Poster Session B on October 24, 2025 from 12:30–4:00 PM ET. The full abstract is available in the conference online program.
Arvinas (NASDAQ: ARVN) reported patient-reported outcomes from the Phase 3 VERITAC-2 trial showing vepdegestrant delayed deterioration in overall quality of life, pain, and multiple functioning domains versus fulvestrant in patients with ESR1-mutated ER+/HER2- advanced or metastatic breast cancer previously treated with endocrine-based therapy.
The trial enrolled 624 patients (270 with ESR1 mutations) across 213 sites in 25 countries; progression-free survival showed a statistically significant improvement and overall survival remains the key secondary endpoint.
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