Arrowhead Pharmaceuticals develops and commercializes RNA interference medicines that silence genes associated with intractable diseases. The company’s TRiM™ platform is used to design targeted RNAi therapeutics for tissues including liver, lung, muscle, adipose and central nervous system tissue.
Recurring ARWR news covers REDEMPLO® (plozasiran), an siRNA medicine approved in the United States and Australia as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome. Company updates also address plozasiran data across hypertriglyceridemia, regulatory actions in additional geographies, pricing and market-access strategy, fiscal results, investor events, and clinical or partnering developments involving programs such as ARO-PNPLA3, ARO-INHBE and ARO-ALK7.
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Arrowhead Pharmaceuticals (NASDAQ: ARWR) recently announced interim results from its ongoing Phase 1/2 study of ARO-RAGE, an RNA interference therapeutic aimed at treating inflammatory pulmonary diseases like asthma. The study reported a mean maximum reduction of 80% in serum soluble RAGE (sRAGE) levels after two doses, with some patients experiencing reductions of up to 90%. The pharmacologic effect lasted at least 6 weeks following the 92 mg dose. No serious adverse events were reported, indicating promising safety and tolerability. Data from the study will be further presented at the upcoming R&D Day on June 1, 2023. This represents a significant step for Arrowhead's therapeutic pipeline, showcasing the potential of its proprietary TRiM platform.