Alterity Therapeutics Limited develops treatments for neurodegenerative diseases, with a clinical program centered on Multiple System Atrophy and related Parkinsonian disorders. News about ATHE commonly covers ATH434, its lead MSA candidate, Phase 2 analyses, FDA interactions, chemistry, manufacturing and control updates, and presentations at neurology and imaging conferences.
Coverage also includes bioMUSE Natural History Study biomarker work, including quantitative susceptibility mapping MRI for iron dysregulation in MSA, Appendix 4C cash flow and corporate updates, board appointments, and discussions of the company’s drug discovery platform for patentable chemical compounds targeting neurological disease pathology.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has received authorization from the Italian Medicines Agency to conduct a Phase 2 clinical trial for ATH434 targeting Multiple System Atrophy (MSA), a severe Parkinsonian disorder. The trial aims to enroll approximately 60 patients, assessing ATH434's impact on biomarkers and clinical endpoints over 12 months. This approval affirms the company’s strategy to reach a global patient base affected by MSA, with ongoing efforts to open study sites in New Zealand, the UK, and Italy. ATH434, previously successful in Phase 1 trials, has Orphan designation for MSA treatment.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced that its Phase 2 clinical trial for ATH434, aimed at treating Multiple System Atrophy (MSA), is now open for enrollment in New Zealand. MSA is a rare neurodegenerative disease characterized by rapid progression and severe disability. ATH434 is intended to reduce α-synuclein accumulation and restore iron balance in the brain, addressing the disease's underlying pathology. The trial will include approximately 60 patients, assessing efficacy and safety over a 12-month treatment period.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has received approval from the UK's Medicines & Healthcare products Regulatory Agency (MHRA) for its Phase 2 clinical trial of ATH434, aimed at treating Multiple System Atrophy (MSA), a debilitating neurodegenerative condition. The trial will begin in New Zealand and expand to other regions, including the UK and the U.S. ATH434 targets protein aggregation and aims to improve patient outcomes. This follows a successful Phase 1 trial, highlighting ATH434's potential as a novel treatment for patients with no current options.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced new data from its ongoing bioMUSE study at the AAN Annual Meeting on April 6, 2022. This natural history study tracks disease progression in early Multiple System Atrophy (MSA) patients. It highlights a correlation between iron accumulation in the brain and disease severity, reinforcing the potential of quantitative susceptibility mapping as a biomarker. The study included data from 52 individuals and supports the upcoming global Phase 2 trial of ATH434, aimed at treating MSA by reducing iron accumulation and inhibiting protein aggregation.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology firm focused on treatments for neurodegenerative diseases, announced that CEO David Stamler will present at the 34th Annual Roth Conference on March 14-15, 2022, in Dana Point, California. The company's lead asset, ATH434, targets Parkinsonian disorders, while its drug discovery platform aims to develop innovative treatments. A recorded presentation is available on the Alterity website.
Alterity Therapeutics (ATHE) has announced the publication of research demonstrating that its drug candidate, ATH434, shows promise in treating Multiple System Atrophy (MSA). Published in the Journal of Parkinson's Disease, the study revealed that ATH434 reduced toxic forms of α-synuclein in a murine model, preserved neurons, and improved motor performance. The research led by Dr. David Finkelstein highlighted ATH434's potential for clinical application, with ongoing Phase 2 trials planned. The compound has received Orphan Drug designation from the FDA and the European Commission.
Alterity Therapeutics Limited (ASX: ATH, NASDAQ: ATHE) has received authorization from New Zealand's Medsafe for a Phase 2 clinical trial of its lead drug candidate ATH434, targeting Multiple System Atrophy (MSA). The trial aims to assess ATH434's impact on imaging and biomarkers over 12 months. The company reported a cash position of A$37M as of December 31, 2021, with operating cash outflows of A$4M. Additionally, a recent US patent grants exclusivity for a new class of iron chaperones, potentially beneficial for treating Parkinson's and Alzheimer's diseases.
Alterity Therapeutics (NASDAQ: ATHE) announced the granting of a new patent (No. 11,155,547) by the USPTO for compounds designed to treat neurodegenerative diseases, including Parkinson's and Alzheimer's. This composition of matter patent covers over 80 novel iron chaperone compounds, ensuring exclusivity until 2041. CEO David Stamler emphasized the significance of this patent in establishing the company as a leader in targeting iron for disease modification. The company is also seeking patent protection in other regions to strengthen its drug development and commercialization efforts.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology company focused on neurodegenerative disease treatments, announced that CEO David Stamler will present at the H.C. Wainwright BIOCONNECT Virtual Conference from January 10-13, 2022. The presentation will be available on the company's website starting January 10, 2022 at 7:00 a.m. ET.
Alterity's lead asset, ATH434, targets various Parkinsonian disorders, underpinned by a broad drug discovery platform.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has received authorization from New Zealand's Medsafe for its Phase 2 clinical trial of ATH434 in treating Multiple System Atrophy (MSA), a rare neurodegenerative disorder. The trial, set to begin in Q1 2022, will evaluate the drug's impact on α-synuclein aggregation and iron balance in the brain. ATH434 has shown promise in Phase 1 trials for safety and bioavailability. This milestone positions Alterity to potentially address the unmet needs of MSA patients, for whom there are currently no disease-modifying treatments.