AUTOLUS THERAPEUTICS PLC Stock Price, News & Analysis

Autolus Therapeutics (Nasdaq: AUTL) announced on December 21, 2022, that underwriters have exercised a partial option to buy an additional 6,927,102 American Depositary Shares (ADSs) at $2.00 each. This move will yield roughly $13.9 million in gross proceeds, bringing the total raised from the public offering to approximately $163.9 million. The offering, which closed on December 13, 2022, involved a total of 81,927,102 ADSs sold. Jefferies LLC, William Blair & Company, and Wells Fargo Securities acted as joint bookrunners for the offering.

Autolus Therapeutics (Nasdaq: AUTL) presented promising updates on its clinical trials at the ASH Annual Meeting. In the ALLCAR19 trial, 35% of adult relapsed/refractory B-ALL patients achieved sustained complete remission after three years without additional therapy. The AUTO1/22 trial showed an 83% MRD negative complete response rate in challenging pediatric B-ALL cases, with no antigen-negative relapses. Additionally, AUTO4 demonstrated sustained metabolic complete remissions in peripheral T-cell lymphoma patients. Full data from the pivotal FELIX trial is expected in mid-2023.

Autolus Therapeutics plc (Nasdaq: AUTL) announced the pricing of a public offering of 75 million American Depositary Shares (ADSs) at $2.00 each, totaling $150 million in gross proceeds. The offering, set to close on December 13, 2022, includes a 30-day option for underwriters to purchase an additional 11.25 million ADSs. The proceeds will support the development of its next-generation T cell therapies targeting cancer treatment. Jefferies LLC, William Blair, and Wells Fargo Securities are the joint bookrunners for this offering.

Autolus Therapeutics plc (Nasdaq: AUTL) has initiated an underwritten public offering of American Depositary Shares (ADSs), with each ADS representing one ordinary share. The company plans to grant underwriters a 30-day option to purchase up to 15% of the ADSs sold at the public offering price. The offering is subject to market conditions and no assurance can be given regarding its completion or terms. Jefferies LLC, William Blair & Company, and Wells Fargo Securities are the joint bookrunners. The securities are offered under an effective shelf registration statement with the SEC.

Autolus Therapeutics (AUTL) has secured two milestone payments of $35 million each from Blackstone Life Sciences, totaling $70 million, due to positive interim results from the pivotal FELIX Phase 2 trial of their CAR T cell therapy, obecabtagene autoleucel (obe-cel). The first payment was received earlier than expected due to the trial meeting its primary endpoint. The second payment follows the successful demonstration of the manufacturing process for obe-cel. Autolus aims to submit a Biologics License Application to the FDA by the end of 2023.

Autolus Therapeutics plc (AUTL) announced positive interim results from its Phase 2 FELIX trial for obe-cel in relapsed/refractory adult Acute Lymphoblastic Leukemia (ALL). The study showed a promising Overall Remission Rate (ORR) of 70% among 50 evaluated patients. Safety data indicated low rates of serious adverse events, with 3% experiencing Grade 3 Cytokine Release Syndrome (CRS) and 8% experiencing Grade 3 Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). Additionally, a $35 million milestone payment from Blackstone Life Sciences was triggered.

Autolus Therapeutics (Nasdaq: AUTL) announced the completion of the first clean room at its new commercial manufacturing facility named ‘The Nucleus’ in Stevenage, UK. This milestone is part of a broader £120 million redevelopment project aimed at creating a life sciences district, housing a cluster of cell and gene therapy companies. The facility is expected to enhance Autolus' capacity for next-generation T cell therapies. Collaboration among Autolus, Reef Group, and Merit facilitated timely project delivery despite challenges posed by the pandemic and supply chain issues.

Autolus Therapeutics (NASDAQ: AUTL) announced the online publication of three abstracts for the upcoming American Society of Hematology Annual Meeting in December 2022. These abstracts will highlight the clinical data of three therapies: obe-cel in B-ALL and B-NHL, AUTO1/22 in pediatric ALL, and AUTO4 in T-Cell Lymphoma. CEO Dr. Christian Itin emphasized obe-cel's promising safety and efficacy profile, showing potential in long-term remission for B-ALL patients. The presentations are set for December 11 and 12, providing updated data for clinical trials.

Autolus Therapeutics plc (Nasdaq: AUTL) announced its Q3 2022 operational and financial results, highlighting several strategic progress points. The pivotal FELIX Phase 2 trial for obe-cel in relapsed/refractory adult ALL is on track for a Q4 2022 update. The commercial manufacturing facility in the UK is scheduled for completion in Q4 2022. Financially, cash decreased to $163.1 million, while the net loss expanded to $42.8 million compared to $34.0 million in Q3 2021. The company expects future pipeline updates at the upcoming ASH Annual Meeting in December 2022.