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AstraZeneca PLC (AZN) is a global biopharmaceutical leader focused on oncology, cardiovascular, respiratory, and immunology research. This centralized hub provides verified company announcements, press releases, and market-moving developments from authoritative sources.
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New data from the Phase IIa COURSE trial suggests TEZSPIRE (tezepelumab) may reduce COPD exacerbations. The trial, involving 337 patients, showed a 17% reduction in annual COPD exacerbation rates compared to placebo, which was not statistically significant. However, in patients with blood eosinophil counts (BEC) ≥150 cells/µL, a significant 37% reduction was noted. For BEC ≥300 cells/µL, the reduction was 46%. Improvements in lung function and quality of life were also reported. Safety profiles were consistent with TEZSPIRE’s use in severe asthma. AstraZeneca and Amgen are planning Phase III trials based on these promising results.
AstraZeneca's CALQUENCE in combination with standard-of-care chemoimmunotherapy demonstrated a significant improvement in progression-free survival in mantle cell lymphoma patients. The trial also showed a favorable trend in overall survival, potentially extending patient survival. The safety profile of CALQUENCE remains consistent with known data, with no new safety concerns identified. The positive results from the ECHO Phase III trial could set a new standard of care for mantle cell lymphoma patients, transforming treatment outcomes earlier in the disease course.
AstraZeneca presents new data for TEZSPIRE and BREZTRI at ATS 2024 focusing on innovative treatments for COPD, severe asthma, and other respiratory diseases. Key highlights include the COURSE Phase IIa trial investigating tezepelumab in COPD patients and the potential of BREZTRI to reduce cardiopulmonary risk in COPD. The PR also covers advancements in asthma treatment, early pipeline science, and real-world evidence in COPD and asthma patients.