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AstraZeneca news coverage focuses on drug development milestones that can significantly impact the company's long-term growth trajectory. As a major pharmaceutical manufacturer with extensive oncology, cardiovascular, respiratory, and immunology franchises, the company generates news across multiple therapeutic areas. Clinical trial results represent particularly significant announcements, as positive outcomes can validate billion-dollar development programs while setbacks can eliminate years of research investment. Regulatory decisions by agencies like the FDA and European Medicines Agency determine whether new treatments can reach patients and generate revenue, making these announcements critical events for investors tracking AstraZeneca.
Financial news for AstraZeneca includes quarterly earnings reports that break down performance by therapeutic area and geographic region, revealing which drug franchises are growing and where the company faces headwinds from patent expirations or pricing pressure. Pharmaceutical companies experience unique revenue dynamics where blockbuster drugs can lose most of their sales within months of patent expiration as generic competitors enter the market. AstraZeneca's news flow often includes updates on partnership agreements with biotechnology companies and academic institutions, as these collaborations increasingly drive innovation in an industry where internal research programs alone cannot address the scientific complexity of modern drug development.
Manufacturing and supply chain announcements carry particular weight in the pharmaceutical sector, where production capacity constraints or quality issues can disrupt product availability. AstraZeneca's investments in new manufacturing facilities signal confidence in pipeline products that will require large-scale production. The company also generates news through patent litigation, as pharmaceutical intellectual property protection directly determines how long products can generate premium pricing before facing generic competition. For investors following AstraZeneca, monitoring this news stream provides insight into the company's scientific progress, commercial execution, and ability to navigate the complex regulatory and competitive landscape of global pharmaceuticals.
AstraZeneca reported strong Q1 2025 financial results with total revenue up 10% to $13,588 million. The growth was driven by double-digit performance in Oncology and BioPharmaceuticals across all major regions. Core EPS increased 21% to $2.49, while reported EPS rose 34% to $1.88.
The quarter saw five positive Phase III readouts and 13 approvals in major regions. Key clinical successes included DESTINY-Breast09 for Enhertu, SERENA-6 for camizestrant, and MATTERHORN for Imfinzi. The company maintains its 2025 guidance, expecting high single-digit revenue growth and low double-digit Core EPS growth.
Strategic developments include the acquisition of EsoBiotec for up to $1 billion, FibroGen China purchase for $160 million, and establishment of a new R&D center in Beijing. The company is progressing toward its 2030 ambition of $80 billion in Total Revenue, supported by eleven US production sites and planned investments in manufacturing and R&D.
Puma Biotechnology presented clinical data for neratinib at the AACR Annual Meeting 2025 in Chicago. The Phase I trial (NCI 10495) evaluated the combination of neratinib with trastuzumab deruxtecan in patients with HER2-altered solid tumors.
Key findings from the 20-patient trial:
- Most common side effects: nausea (75%), diarrhea (75%), fatigue (65%)
- 4 patients achieved partial responses, including cases of gastroesophageal, pancreatic, and ovarian cancers
- Notable results in pancreatic cancer: 3 of 5 patients showed tumor shrinkage
The study established Dose Level 3 as the recommended Phase II dose: trastuzumab deruxtecan at 5.4 mg/kg combined with neratinib starting at 120 mg (week 1), increasing to 160 mg (week 2), and 240 mg (week 3 onward). Part 2 of the study, focusing on pharmacodynamic evaluation in 12 patients, began enrollment in March 2025.
SOPHiA GENETICS and AstraZeneca are expanding their collaboration to accelerate global liquid biopsy testing deployment. The partnership will extend MSK-ACCESS powered with SOPHiA DDM to 30 clinical institutions worldwide in 2025.
Key highlights:
- The liquid biopsy test detects genomic alterations from a single blood draw using advanced algorithms to analyze circulating tumor DNA
- This testing method offers advantages when traditional tissue biopsies are impractical due to cost, time, or invasiveness
- New data presented at AACR shows consistent accuracy across different laboratory settings
The expanded rollout supports AstraZeneca's real-world evidence initiatives and aims to validate decentralized liquid biopsy testing's clinical impact. The collaboration addresses a major industry challenge, as site-to-site result consistency has historically limited liquid biopsy adoption. Recent study results confirm the test maintains high analytical performance across multiple centers, matching the original standards set at Memorial Sloan Kettering Cancer Center.
Tempus AI (NASDAQ: TEM) has announced multi-year strategic collaborations with AstraZeneca and Pathos AI to develop the largest multimodal foundation model in oncology. The partnerships will focus on:
- Gathering biological and clinical insights
- Discovering novel drug targets
- Developing therapeutics for the oncology community
The agreements include $200 million in data licensing and model development fees to Tempus. The collaboration expands on Tempus' existing 2021 partnership with AstraZeneca, utilizing Tempus' AI-enabled platform and multimodal data repository to advance therapeutic programs in oncology globally. The foundation model will be built using Tempus' de-identified oncology data and will be shared among all three parties to enhance their respective patient care initiatives.
ENHERTU in combination with pertuzumab has shown highly significant improvement in progression-free survival (PFS) compared to current first-line standard treatment (taxane, trastuzumab and pertuzumab - THP) for HER2-positive metastatic breast cancer patients in the DESTINY-Breast09 Phase III trial.
This marks the first trial in over a decade demonstrating superior efficacy across broad HER2-positive metastatic breast cancer population versus current standard care. The PFS improvement was observed across all pre-specified patient subgroups. While overall survival data wasn't mature, early trends favor the ENHERTU combination.
HER2-positive metastatic breast cancer affects 15-20% of metastatic breast cancer patients. Despite current treatments, most patients experience disease progression within two years of first-line THP treatment, with approximately one-third never receiving second-line therapy due to progression or death.
AstraZeneca (AZN) and Daiichi Sankyo reported positive topline results from the DESTINY-Breast09 phase 3 trial, showing ENHERTU combined with pertuzumab significantly improved progression-free survival compared to current standard treatment in first-line HER2 positive metastatic breast cancer patients.
The trial demonstrated superior efficacy across all pre-specified patient subgroups. While overall survival data was not mature, early trends favor the ENHERTU combination. This marks the first trial in over a decade showing superior efficacy versus the current first-line standard of care for broad HER2 positive metastatic breast cancer patients.
HER2 positive metastatic breast cancer affects 15-20% of metastatic breast cancer patients, with most experiencing disease progression within two years of first-line treatment. The safety profile of ENHERTU with pertuzumab aligned with known profiles of each therapy. Regulatory submissions are now underway.
DATROWAY® (datopotamab deruxtecan) has received EU approval for treating adult patients with unresectable or metastatic HR positive, HER2 negative breast cancer who have undergone endocrine therapy and at least one chemotherapy line in advanced settings. The approval is based on the TROPION-Breast01 phase 3 trial results.
Key findings show DATROWAY reduced disease progression or death risk by 37% compared to standard chemotherapy. The median progression-free survival was 6.9 months for DATROWAY versus 4.9 months with chemotherapy. The objective response rate was 36% for DATROWAY compared to 23% for chemotherapy, with a median duration of response of 6.7 months versus 5.7 months respectively.
Overall survival results were not statistically significant, with median OS of 18.6 months for DATROWAY versus 18.3 months for chemotherapy. The most common Grade 3 or higher adverse events included stomatitis (7.9%), fatigue (4.3%), and anemia (3.2%).
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