Bridgebio Pharma Stock Price, News & Analysis

BridgeBio Pharma (BBIO) announced positive Phase 1 data for BBP-711, a novel oral therapy aimed at treating primary hyperoxaluria type 1 (PH1) and recurrent kidney stone formation. Results indicated near complete inhibition of glycolate oxidase, significantly increasing plasma glycolate levels. Following its promising tolerability and efficacy, BridgeBio plans to initiate a pivotal Phase 2/3 study by the end of 2022, as well as a Phase 2 study targeting adult recurrent kidney stone formers, which impacts 1.5 million individuals in the U.S. and EU.

BridgeBio Pharma announced promising results from the Phase 1/2 clinical trial of BBP-812, a gene therapy for Canavan disease. Initial data from two participants revealed significant decreases in N-acetylaspartate (NAA) levels in the brain and urine, indicating the therapy may effectively target disease markers. With no serious adverse events reported, the trial is progressing well. If successful, BBP-812 could be the first treatment option for this ultra-rare, fatal condition affecting approximately 1,000 children in the U.S. and EU.

BridgeBio Pharma announced positive Phase 2b results for encaleret, targeting autosomal dominant hypocalcemia type 1 (ADH1). By day 5 of treatment, participants showed restored normal calcium homeostasis, with 92% achieving normal trough blood calcium levels. The company is scheduling a Phase 3 study to commence in 2022, assessing encaleret against standard care. The results are presented at ENDO 2022, and an investor call is scheduled for June 13, 2022, to discuss findings and future plans.

BridgeBio Pharma (Nasdaq: BBIO) and Venthera, Inc. presented preliminary data from the Phase 1b trial of VT30 topical gel, targeting venous and lymphatic lesions. The trial showed that VT30 was generally well-tolerated across 15 participants, with mild to moderate local rashes as the only notable adverse effect. Importantly, pharmacokinetic data indicated drug concentrations were sufficient within lesions, while no systemic drug was detected in plasma. Venthera plans to advance the 0.6% gel into further studies and is seeking development partners.

BridgeBio Pharma (BBIO) announced that preliminary data from a 24-week Phase 2b study of encaleret in treating autosomal dominant hypocalcemia type 1 (ADH1) will be presented at the Endocrine Society's Annual Conference on June 13, 2022. This data suggests that encaleret restores mineral homeostasis, marking a significant step in clinical research. Alongside this, comprehensive presentations on various programs, including achondroplasia and congenital adrenal hyperplasia, will also be discussed. An investor call is slated for the same day to focus on the Phase 2b data.

BridgeBio Pharma, Inc. (Nasdaq: BBIO) announced participation in two key investor conferences. The Jefferies Healthcare Conference is scheduled for June 9 at 4:00 pm ET, followed by the Goldman Sachs Global Healthcare Conference on June 15 at 5:00 pm ET.

Live webcasts will be available on the BridgeBio Investors page. A replay will be accessible for 90 days post-event. Founded in 2015, BridgeBio focuses on developing transformative medicines targeting genetic diseases and cancers.

BridgeBio Pharma announced promising interim Phase 1 data for BBP-671, an investigational therapy targeting pantothenate kinase-associated neurodegeneration (PKAN) and organic acidemias. The study found BBP-671 in healthy volunteer plasma and cerebrospinal fluid, indicating its ability to cross the blood-brain barrier. Additionally, it elevated whole blood acetyl-CoA levels, demonstrating proof of mechanism. The company plans to advance to the next study phase for propionic acidemia and methylmalonic acidemia in late 2022 and initiate a pivotal study for PKAN in 2023.

BridgeBio Pharma, Inc. (BBIO) announced positive results from a Phase 2 trial of PTR-01, a recombinant collagen 7 protein replacement therapy for recessive dystrophic epidermolysis bullosa (RDEB). The treatment demonstrated rapid and consistent wound healing, with over 80% of wounds showing a significant reduction in size. Patients reported a 36% mean reduction in pain, and the therapy was well-tolerated over four months. The findings were presented at the Society for Investigative Dermatology Annual Meeting. Phoenix Tissue Repair has commenced a Phase 2 extension study for further evaluation.

BridgeBio Pharma, Inc. (Nasdaq: BBIO) announced participation in several investor conferences. Key events include the Citi Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Panel on May 18 at 2:30 PM ET, and multiple sessions on May 24, including H. C. Wainwright Global Investment Conference at 7:00 AM ET, UBS Global Healthcare Conference at 11:30 AM ET, and J. P. Morgan West Coast Investor Day at 12:00 PM ET. For more details, visit the BridgeBio Investors page.