Welcome to our dedicated page for Bridgebio Pharma news (Ticker: BBIO), a resource for investors and traders seeking the latest updates and insights on Bridgebio Pharma stock.
BridgeBio Pharma (BBIO) is a biopharmaceutical innovator developing genetic disease therapies through its unique portfolio-based approach. This page serves as the definitive source for official company announcements, clinical trial updates, and strategic developments.
Investors and stakeholders gain centralized access to critical updates including clinical milestones, regulatory filings, financial disclosures, and research partnerships. Our curated feed ensures timely tracking of therapeutic advancements across BridgeBio's diversified pipeline.
Key focus areas include progress in Mendelian disorder treatments, oncology targets, and gene therapy innovations. All content undergoes strict verification to maintain compliance with financial disclosure standards and medical accuracy guidelines.
Bookmark this page for efficient monitoring of BBIO's scientific advancements and corporate developments. Combine this resource with SEC filings and earnings transcripts for comprehensive investment analysis.
BridgeBio Pharma (BBIO) has received UK approval for BEYONTTRA® (acoramidis), the first near-complete TTR stabilizer (≥90%) for treating ATTR-CM (transthyretin amyloidosis with cardiomyopathy). The approval is based on the Phase 3 ATTRibute-CM study results, which demonstrated:
- 42% reduction in composite all-cause mortality and recurrent cardiovascular-related hospitalization events at Month 30
- 50% reduction in cumulative frequency of cardiovascular hospitalization events
- Rapid benefit showing separation from placebo in as few as 3 months
BEYONTTRA is now approved in the US, EU, UK, and Japan. Under a collaboration agreement with Bayer, who will handle UK commercialization, BridgeBio will receive tiered royalties starting in the low-thirties percent on sales.
BridgeBio Pharma (Nasdaq: BBIO), a biopharmaceutical company specializing in genetic diseases, has scheduled its first quarter 2025 financial results conference call for Tuesday, April 29, 2025, at 4:30 pm ET. The company will release its Q1 financial results and program updates after market close on the same day.
Investors and interested parties can access the live webcast through the 'Events' page in the Investors section of BridgeBio's website. A replay will remain available for 30 days following the event. Registration for the webcast is available through a dedicated online link.
BridgeBio Pharma (BBIO) has announced new equity grants approved by its compensation committee on April 9, 2025. The grants consist of restricted stock units totaling 77,652 shares, awarded to 20 new employees.
The vesting schedule specifies that one-fourth of each employee's shares will vest on May 16, 2026, followed by quarterly vesting of one-twelfth of the remaining shares, contingent on continued employment. These inducement grants were made under the company's Amended and Restated 2019 Inducement Equity Plan, in accordance with Nasdaq Listing Rule 5635(c)(4).
BBOT has announced the dosing of its first patient with BBO-11818 in the Phase 1 KONQUER-101 trial for advanced solid tumors. BBO-11818 is an orally bioavailable small molecule that acts as a panKRAS dual inhibitor, binding to both 'ON' and 'OFF' states of KRAS with picomolar affinity.
The drug demonstrates sub-nanomolar to single-digit nanomolar potency in cellular assays for pERK inhibition in KRAS G12D and G12V-mutant cell lines. It shows effectiveness in reducing cell viability across KRASG12D, KRASG12V, and KRASG12C-mutant cell lines, with over 500-fold selectivity for KRAS over H- and NRAS.
This marks BBOT's third molecule entering clinical trials, positioning the company to potentially deliver combination therapy through MAPK and PI3Kα/AKT co-inhibition for patients with RAS-driven cancers.
BridgeBio Pharma (BBIO) announced significant clinical outcomes for acoramidis in treating transthyretin amyloid cardiomyopathy (ATTR-CM). The drug showed a 59% risk reduction in variant ATTR-CM patients and 31.2% reduction in wild-type ATTR-CM patients for the composite of all-cause mortality (ACM) and cardiovascular-related hospitalization (CVH).
Key highlights from the ATTRibute-CM Phase 3 trial include:
- Hazard ratio of 0.41 for ATTRv-CM patients
- 42% reduction in composite ACM and recurrent CVH events at Month 30
- 50% reduction in cumulative CVH events at Month 30
- Benefits observed in as few as 3 months
Acoramidis, approved as Attruby™ in the US and BEYONTTRA™ in Europe and Japan, demonstrates near-complete (≥90%) TTR stabilization. The drug showed improved outcomes in both variant and wild-type ATTR-CM patients, with statistically significant results in both subgroups.
BridgeBio Pharma (BBIO) announced the Japanese approval of Beyonttra™ (acoramidis) for treating ATTR-CM (transthyretin-mediated amyloid cardiomyopathy) in adults. The approval stems from successful Phase 3 trials, including a Japanese study reporting 0% mortality over 30 months and a global ATTRibute-CM trial showing significant benefits.
Key clinical achievements include:
- 42% reduction in composite all-cause mortality and recurrent cardiovascular-related hospitalization events at Month 30
- 50% reduction in cumulative cardiovascular-related hospitalization events at Month 30
- Benefits observed as early as 3 months into treatment
Through its partnership with Alexion, AstraZeneca Rare Disease, BridgeBio will receive a $30 million milestone payment and low double-digit royalties on Japanese sales. Commercial launch is planned for first half 2025.
BridgeBio Pharma (Nasdaq: BBIO) has announced the presentation of cardiovascular outcomes data from their ATTRibute-CM Phase 3 study of acoramidis in ATTR-CM at the upcoming American College of Cardiology (ACC) Annual Scientific Sessions in Chicago, March 29-31, 2025.
The company will present seven studies, including five flatboard poster presentations and two moderated posters, focusing on various aspects of acoramidis treatment in ATTR-CM patients. Key presentations include:
- Acoramidis's impact on serum TTR levels in wild-type and variant ATTR-CM patients
- Improvements in NYHA Class at Month 30 versus placebo
- Effects of combining acoramidis with tafamidis
- Primary endpoint efficacy results and NT-proBNP sensitivity analyses
- Relationship between early serum transthyretin increase and reduced cardiovascular hospitalizations
- Geographic healthcare disparities in ATTR-CM diagnosis
BridgeBio Pharma (Nasdaq: BBIO) has announced new equity grants approved by its compensation committee on March 19, 2025. The grants consist of restricted stock units totaling 30,782 shares, awarded to 10 new employees.
The vesting schedule specifies that one-fourth of each employee's shares will vest on February 16, 2026, followed by quarterly vesting of one-twelfth of the remaining shares, contingent on continued employment. These inducement grants were made under BridgeBio's Amended and Restated 2019 Inducement Equity Plan, in accordance with Nasdaq Listing Rule 5635(c)(4).
BridgeBio Pharma (Nasdaq: BBIO) announced a leadership transition as Thomas Trimarchi, Ph.D. has been appointed as President and Chief Financial Officer (CFO). Dr. Trimarchi, who recently became Principal Financial Officer, will continue leading the company's FP&A and accounting operations.
The current CFO, Brian Stephenson, Ph.D., is departing for personal reasons and will transition to a consulting role. The company confirmed that Dr. Stephenson's departure is not related to any disagreements regarding company operations, policies, or practices.
Deep Track Capital, owning 14.34% of Dynavax Technologies (NASDAQ: DVAX), has sent a letter to the company's Board expressing concerns about capital allocation and governance. The letter highlights strong shareholder support for Deep Track's position and criticizes the Board's recent decision to issue $265 million in convertible notes instead of using available cash.
The investment firm nominated four candidates for the Board election at the 2025 Annual Meeting, seeking to improve corporate strategy and governance. Deep Track emphasizes that DVAX stock has risen 34% since their involvement in October 2024, while the biotech sector indices declined. They dispute the company's claim that they seek board control, noting they aim for four seats on a nine-member board.
The letter criticizes the Board's defensive tactics and highlights widespread shareholder support for having Deep Track representation, focusing on Heplisav's potential, and improving capital allocation strategies.
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