Biocryst Pharmaceuticals Inc Stock Price, News & Analysis

BioCryst Pharmaceuticals (BCRX) announced the grant of inducement stock options to 10 newly-hired employees on December 31, 2020, allowing the purchase of 240,500 shares at $7.45 each, equal to the stock’s closing price on the grant date. These options vest in four equal annual installments, subject to continued service. The initiative complies with Nasdaq Listing Rule 5635(c)(4), aiming to attract talent and align incentives with the company’s growth strategy.

BioCryst Pharmaceuticals (Nasdaq: BCRX) will present at the 39th Annual J.P. Morgan Healthcare Conference on January 13, 2021, at 11:40 a.m. ET via a virtual event. Interested parties can access a live audio webcast and replay through the Investors section of BioCryst’s website. The company focuses on developing oral medicines for rare diseases, with products like ORLADEYO™ approved in the U.S. for HAE prevention and others in development, including BCX9930 and galidesivir for various conditions.

BioCryst Pharmaceuticals (BCRX) announced the results of part 1 of a clinical trial for its antiviral drug, galidesivir, targeting SARS-CoV-2. The trial demonstrated that galidesivir was safe and well tolerated among patients, although it did not show clinical efficacy compared to placebo. The company will refocus its efforts on galidesivir for biodefense against diseases like Marburg virus, discontinuing its COVID-19 indication. The trial, conducted in Brazil, involved 24 patients and revealed a rapid decline in viral RNA levels with no safety concerns.

BioCryst Pharmaceuticals (BCRX) announced positive results from a Phase 1 clinical trial of BCX9250, an oral ALK-2 inhibitor for fibrodysplasia ossificans progressiva (FOP). The trial demonstrated safety and tolerability at all doses studied, supporting once-daily administration. No serious adverse events occurred, and pharmacokinetics showed dose-proportional exposure. With no current treatments available for FOP, these results provide hope for patients. BioCryst plans further discussions with physicians and regulators to advance BCX9250 development.

BioCryst Pharmaceuticals (BCRX) has initiated direct shipments of ORLADEYO™ (berotralstat), the first oral once-daily prophylactic treatment for hereditary angioedema (HAE) in patients aged 12 and older. Following FDA approval on December 3, 2020, Optime Care, the exclusive specialty pharmacy, has commenced shipments. The EMPOWER Patient Services program provides streamlined access and financial support to HAE patients, aiming for a comprehensive treatment journey. ORLADEYO is designed to reduce plasma kallikrein activity, preventing HAE attacks, but should not be used for acute attack treatment.

BioCryst Pharmaceuticals (BCRX) will present at the JMP Securities Hematology Summit on December 15, 2020, at 3:30 p.m. ET. This virtual event allows investors to access a live audio webcast of the presentation through the company's website. BioCryst focuses on developing oral, small-molecule medicines for rare diseases. Its approved product, ORLADEYO™, prevents HAE attacks and is currently under review in Japan and the EU. The company has several ongoing programs, including treatments for COVID-19 and other serious diseases.

BioCryst Pharmaceuticals (Nasdaq: BCRX) has secured $325 million in funding, including $250 million at closing, to bolster the launch of ORLADEYO™ (berotralstat) for hereditary angioedema (HAE) and advance its oral Factor D inhibitor, BCX9930. The financing comprises a $125 million upfront payment from Royalty Pharma with an 8.75% royalty structure on sales up to $350 million, and a $200 million credit facility from Athyrium Capital. The funds will also enable BioCryst to repay existing debt and expand its clinical trials amid promising early data for BCX9930.

BioCryst Pharmaceuticals (Nasdaq: BCRX) announced promising preclinical data for BCX9930, an oral Factor D inhibitor aimed at treating paroxysmal nocturnal hemoglobinuria (PNH) and other complement-mediated diseases. The data, presented at the 62nd ASH Annual Meeting, showed complete in vitro blockade of hemolysis in PNH erythrocytes. BCX9930 demonstrated specificity for the alternative pathway, with significant suppression observed in primates. The FDA has granted Fast Track status and Orphan Drug designation for BCX9930.

BioCryst Pharmaceuticals (BCRX) announced FDA approval for ORLADEYO™ (berotralstat), an oral, once-daily prophylactic treatment for hereditary angioedema (HAE) in patients aged 12 and older. The pivotal Phase 3 APeX-2 trial showed a significant reduction in HAE attacks, from 2.9 to 1.0 per month after 48 weeks. With EMPOWER Patient Services, access to therapy is streamlined, providing dedicated support for patients. ORLADEYO represents a critical advancement, reducing treatment burden compared to existing injectable therapies.