BriaCell Awarded $2 Million NCI Grant to Advance Bria-PROS+™ in Prostate Cancer
BriaCell Therapeutics (NASDAQ: BCTX) has secured a $2.05 million non-dilutive grant from the National Cancer Institute (NCI) to advance Bria-PROS+™, its next-generation personalized off-the-shelf immunotherapy for prostate cancer. The funding will support the manufacturing and upcoming Phase 1/2a clinical trial for patients with metastatic prostate cancer.
The study will be led by Dr. William Oh from Yale Cancer Center as Principal Investigator. The Bria-OTS+ platform aims to address the challenges of traditional personalized cancer treatments by offering a more streamlined approach to immunotherapy for patients with advanced prostate cancer.
BriaCell Therapeutics (NASDAQ: BCTX) ha ottenuto una sovvenzione non diluiva di 2,05 milioni di dollari dal National Cancer Institute (NCI) per portare avanti Bria-PROS+™, la sua immunoterapia personalizzata off-the-shelf di nuova generazione per il cancro alla prostata. Il finanziamento coprirà la produzione e il prossimo trial clinico di Fase 1/2a per pazienti con carcinoma prostatico metastatico.
Lo studio sarà guidato come investigatore principale dal dott. William Oh del Yale Cancer Center. La piattaforma Bria-OTS+ mira a superare i limiti delle terapie oncologiche personalize tradizionali offrendo un approccio più snello all'immunoterapia per i pazienti con carcinoma prostatico avanzato.
BriaCell Therapeutics (NASDAQ: BCTX) ha obtenido una subvención no dilutiva de 2,05 millones de dólares del National Cancer Institute (NCI) para impulsar Bria-PROS+™, su inmunoterapia personalizada off-the-shelf de nueva generación para el cáncer de próstata. Los fondos respaldarán la fabricación y el próximo ensayo clínico de Fase 1/2a en pacientes con cáncer de próstata metastásico.
El estudio estará dirigido por el Dr. William Oh del Yale Cancer Center como investigador principal. La plataforma Bria-OTS+ pretende afrontar los desafíos de los tratamientos oncológicos personalizados tradicionales ofreciendo un enfoque más ágil de la inmunoterapia para pacientes con cáncer de próstata avanzado.
BriaCell Therapeutics (NASDAQ: BCTX)가 전립선암 차세대 맞춤형 오프더쉘프 면역치료제인 Bria-PROS+™ 개발을 위해 국립암연구소(NCI)로부터 205만 달러의 비희석성 보조금을 확보했습니다. 이 자금은 제조와 전이성 전립선암 환자를 대상으로 한 예정된 1/2a상 임상시험을 지원합니다.
해당 연구는 예일 암센터의 윌리엄 오 박사가 책임연구자로 이끌 예정입니다. Bria-OTS+ 플랫폼은 기존의 맞춤형 암 치료가 가진 한계를 극복하고, 진행성 전립선암 환자에게 보다 간소화된 면역치료 접근을 제공하는 것을 목표로 합니다.
BriaCell Therapeutics (NASDAQ: BCTX) a obtenu une subvention non dilutive de 2,05 millions de dollars du National Cancer Institute (NCI) pour faire progresser Bria-PROS+™, sa thérapie immunitaire personnalisée off-the-shelf de nouvelle génération pour le cancer de la prostate. Le financement soutiendra la fabrication et le prochain essai clinique de phase 1/2a chez des patients atteints d'un cancer de la prostate métastatique.
L'étude sera dirigée par le Dr William Oh du Yale Cancer Center en tant qu'investigateur principal. La plateforme Bria-OTS+ vise à répondre aux limites des traitements oncologiques personnalisés traditionnels en proposant une approche d'immunothérapie plus rationalisée pour les patients atteints d'un cancer de la prostate avancé.
BriaCell Therapeutics (NASDAQ: BCTX) hat einen nicht verwässernden Zuschuss über 2,05 Millionen US-Dollar vom National Cancer Institute (NCI) erhalten, um Bria-PROS+™, seine nächste Generation der personalisierten Off-the-Shelf-Immuntherapie gegen Prostatakrebs, voranzutreiben. Die Finanzierung unterstützt die Herstellung und die bevorstehende Phase-1/2a-Studie bei Patienten mit metastasiertem Prostatakrebs.
Die Studie wird vom Dr. William Oh vom Yale Cancer Center als leitendem Prüfarzt geleitet. Die Bria-OTS+-Plattform zielt darauf ab, die Herausforderungen herkömmlicher personalisierter Krebstherapien zu überwinden, indem sie Patienten mit fortgeschrittenem Prostatakrebs einen schlankeren Immuntherapieansatz bietet.
- Secured $2.05M non-dilutive grant from NCI, validating technology potential
- Expansion of Bria-OTS+ platform into prostate cancer treatment
- Partnership with prestigious Yale Cancer Center for clinical trials
- Development addresses significant unmet medical need in metastatic prostate cancer
- None.
Insights
BriaCell secures $2M NCI grant for prostate cancer immunotherapy, advancing their personalized off-the-shelf platform without diluting shareholder value.
The
The strategic importance of this grant cannot be overstated. First, being non-dilutive means BriaCell can advance this program without issuing additional shares that would dilute existing shareholders. Second, receiving NCI funding provides external validation of BriaCell's technology platform from a premier cancer research institution.
From a scientific perspective, the Bria-OTS+ platform represents an innovative approach to personalized immunotherapy. Traditional personalized treatments often involve complex manufacturing processes tailored to each patient, resulting in high costs and treatment delays. BriaCell's off-the-shelf approach potentially offers personalized therapy without these drawbacks.
The expansion into prostate cancer is strategically sound, addressing what the company describes as an "urgent unmet medical need." With Principal Investigator Dr. William Oh from Yale Cancer Center leading the clinical study, the program has credible scientific leadership. Metastatic prostate cancer represents a significant market with limited effective treatment options for advanced cases, as noted in Dr. Oh's statement about patients who progress with "significant pain and suffering and limited treatment options."
This grant allows BriaCell to expand their technology platform beyond their existing programs, potentially creating additional value pathways for the company while derisking development through external funding.
- US
$2,054,651 non-dilutive grant from the US National Cancer Institute to complete manufacturing of Bria-Pros+TM clinical supply and support Phase 1/2a trial in metastatic prostate cancer - Expands Bria-OTS+ novel personalized off-the-shelf immunotherapy platform to prostate cancer, an urgent unmet medical need
- Principal Investigator: Dr. William Oh, MD, Yale Cancer Center
PHILADELPHIA and VANCOUVER, British Columbia, Aug. 25, 2025 (GLOBE NEWSWIRE) -- BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXW, BCTXZ), (TSX: BCT) (“BriaCell” or the “Company”), a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care, is pleased to announce that the National Cancer Institute (NCI), the United States federal government’s principal agency for cancer research and training, has awarded the Company a research grant of
The non-dilutive grant, titled “Phase 1/2a clinical trial to investigate Bria-PROS+™ in patients with metastatic prostate cancer”, will be used to complete manufacturing of Bria-PROS+ and to fund the upcoming Phase 1/2a study in patients with advanced prostate cancer.
“Despite recent advances in the management of metastatic hormone-sensitive prostate cancer, most patients will progress with significant pain and suffering and limited treatment options,” stated Dr. William Oh, MD, Director of Precision Medicine, Yale Cancer Center, and Principal Investigator on the upcoming Phase 1/2a clinical study of Bria-PROS+ in advanced prostate cancer. “We are grateful to the NCI for recognizing the urgency for this unmet medical need and supporting BriaCell’s breakthrough immunotherapy.”
“This prestigious award will help expedite the clinical development of Bria-PROS+ and is significant validation of our next generation novel personalized immunotherapy approach,” added Dr. William V. Williams, BriaCell’s President and CEO.
“The Bria-OTS+ platform was designed to overcome the complexity, cost and delays of traditional personalized cancer treatments,” noted Miguel Lopez-Lago, PhD, BriaCell’s Chief Scientific Officer. “We believe it will constitute a significant advancement in personalized cancer care.”
About BriaCell Therapeutics Corp.
BriaCell is a clinical-stage biotechnology company that develops novel immunotherapies to transform cancer care. More information is available at https://briacell.com/.
Safe Harbor
This press release contains “forward-looking statements” that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as “anticipate,” “believe,” “contemplate,” “could,” “estimate,” “expect,” “intend,” “seek,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “target,” “aim,” “should,” “will,” “would,” or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements include statements regarding the completion of manufacturing of Bria-PROS+; the outcome of the Phase 1/2a clinical trial in metastatic breast cancer; and the ongoing development of Bria-PROS+. These statements are based on BriaCell’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading “Risks and Uncertainties” in the Company’s most recent Management’s Discussion and Analysis, under the heading “Risk Factors” in the Company’s most recent Annual Information Form and under “Risks and Uncertainties” in the Company’s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company’s profiles on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov. Forward-looking statements contained in this announcement are made as of this date and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.
Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.
Contact Information
Company Contact:
William V. Williams, MD
President & CEO
1-888-485-6340
info@briacell.com
Investor Relations Contact:
investors@briacell.com
FAQ
What is the value and purpose of the NCI grant awarded to BriaCell (BCTX)?
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