BioAge Labs Reports First Quarter 2025 Financial Results and Provides Business Updates
Rhea-AI Summary
BioAge Labs (BIOA) reported its Q1 2025 financial results and business updates, highlighting progress in its metabolic disease therapeutics pipeline. The company's lead candidate BGE-102, an oral brain-penetrant NLRP3 inhibitor for obesity, is advancing with initial Phase 1 data expected in H2 2025. BioAge announced a strategic collaboration with Lilly ExploR&D to develop therapeutic antibodies and continues to advance its APJ agonist program for obesity.
Financial results show R&D expenses increased to $11.1 million from $9.3 million YoY, while G&A expenses rose to $6.8 million from $3.5 million. The company reported a net loss of $12.9 million ($0.36 per share). BioAge maintains a strong financial position with $335.1 million in cash and equivalents, expected to fund operations through 2029.
Positive
- Strong cash position of $335.1 million, sufficient to fund operations through 2029
- New strategic collaboration with Lilly ExploR&D for therapeutic antibodies development
- Lead candidate BGE-102 showing potential best-in-class potency in preclinical studies
- Slight improvement in net loss per share from $7.76 in Q1 2024 to $0.36 in Q1 2025
Negative
- R&D expenses increased by $1.8 million YoY to $11.1 million
- G&A expenses nearly doubled to $6.8 million from $3.5 million YoY
- Net loss of $12.9 million for Q1 2025
News Market Reaction
On the day this news was published, BIOA gained 2.78%, reflecting a moderate positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
- Advancement of lead candidate BGE-102, an oral, brain-penetrant NLRP3 inhibitor for obesity, with initial clinical data expected 2H25
- New strategic collaboration with Lilly ExploR&D expands therapeutic approach to novel metabolic aging targets
- Progression of preclinical next-generation APJ agonists for obesity
RICHMOND, Calif., May 06, 2025 (GLOBE NEWSWIRE) -- BioAge Labs, Inc. ("BioAge", “the Company”), a clinical-stage biotechnology company developing therapeutic product candidates for metabolic diseases, such as obesity, by targeting the biology of human aging, today provided business updates and reported its first quarter 2025 financial results.
“The first quarter of 2025 was marked by strategic execution as we advanced our focused pipeline," said Kristen Fortney, Ph.D., CEO and co-founder of BioAge. "We've made significant progress with BGE-102, our brain-penetrant NLRP3 inhibitor, and are on track with IND-enabling studies to bring this potential best-in-class compound to the clinic this year, with initial Phase 1 data expected before year-end. Our new collaboration with Lilly expands our therapeutic capabilities into antibodies while validating our platform-driven approach to targeting the biology of aging. Meanwhile, both our novel APJ agonist program and our partnership with Novartis continue to make meaningful progress. With these scientific advancements and our strong financial position, we're well-positioned to deliver on our mission to leverage the biology of aging to develop transformative treatments for metabolic diseases."
First Quarter 2025 Business Highlights
NLRP3 program development
- In January 2025, BioAge nominated BGE-102, a novel, orally available small-molecule NLRP3 inhibitor, as its lead development candidate for obesity. The compound shows potential best-in-class potency and brain penetration, and can target diseases driven by neuroinflammation including metabolic conditions and obesity. In preclinical studies, NLRP3 inhibition has demonstrated significant weight loss potential. IND-enabling studies are currently underway, with initial Phase 1 data anticipated in the second half of 2025.
Strategic collaborations
- In January 2025, BioAge announced a strategic collaboration with Lilly ExploR&D to develop two therapeutic antibodies targeting novel metabolic aging targets identified through BioAge's discovery platform.
Pipeline advancement
- The Company continues to advance its portfolio of novel, structurally differentiated APJ agonists for obesity and related metabolic conditions, with the goal of nominating a development candidate by the end of 2025. BioAge's multi-year research collaboration with Novartis, focused on discovering novel therapeutic targets at the intersection of aging biology and exercise physiology, continues to make meaningful progress.
First Quarter 2025 Financial Results
Research and development expenses were
General and administrative expenses were
Net loss was
As of March 31, 2025, BioAge had approximately
About BioAge Labs, Inc.
BioAge is a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging. The company’s pipeline includes novel, orally available, brain-penetrant small-molecule NLRP3 inhibitors to treat metabolic diseases and conditions driven by neuroinflammation, as well as novel APJ agonists for metabolic disorders. BioAge’s additional preclinical programs, which leverage insights from the Company’s proprietary discovery platform built on human longevity data, address key pathways involved in metabolic aging.
Forward-looking statements
This press release contains “forward-looking statements” within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding our plans to develop and commercialize our product candidates, the timing and results of our planned clinical trials, risks associated with clinical trials, including our ability to adequately manage clinical activities, the timing of and our ability to obtain and maintain regulatory approvals, the clinical utility of our product candidates, the sufficiency of our cash and cash equivalents, and general economic, industry and market conditions. These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “possible,” “will,” “would,” and other words and terms of similar meaning. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including: our ability to develop, obtain regulatory approval for and commercialize our product candidates; the timing and results of preclinical studies and clinical trials; the risk that positive results in a preclinical study or clinical trial may not be replicated in subsequent trials or success in early stage clinical trials may not be predictive of results in later stage clinical trials; risks associated with clinical trials, including our ability to adequately manage clinical activities, unexpected concerns that may arise from additional data or analysis obtained during clinical trials, regulatory authorities may require additional information or further studies, or may fail to approve or may delay approval of our drug candidates; the occurrence of adverse safety events; failure to protect and enforce our intellectual property, and other proprietary rights; failure to successfully execute or realize the anticipated benefits of our strategic and growth initiatives; risks relating to technology failures or breaches; our dependence on collaborators and other third parties for the development of product candidates and other aspects of our business, which are outside of our full control; risks associated with current and potential delays, work stoppages, or supply chain disruptions, including due to the imposition of tariffs and other trade barriers; risks associated with current and potential future healthcare reforms; risks relating to attracting and retaining key personnel; changes in or failure to comply with legal and regulatory requirements, including shifting priorities within the U.S. Food and Drug Administration; risks relating to access to capital and credit markets; and the other risks and uncertainties that are detailed under the heading “Risk Factors” included in BioAge’s Quarterly Report on Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) on May 6, 2025, and BioAge’s other filings with the SEC filed from time to time. BioAge undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
Contacts
PR: Chris Patil, media@bioagelabs.com
IR: Dov Goldstein, ir@bioagelabs.com
Partnering: partnering@bioagelabs.com
Web: https://bioagelabs.com
| BIOAGE LABS, INC. Unaudited Condensed Consolidated Statements of Operations and Comprehensive Loss (in thousands, except share and per share information) | |||||||
| Three Months Ended | |||||||
| March 31, | |||||||
| 2025 | 2024 | ||||||
| Collaboration revenue | $ | 1,451 | $ | — | |||
| Operating expenses: | |||||||
| Research and development | $ | 11,109 | $ | 9,321 | |||
| General and administrative | 6,788 | 3,492 | |||||
| Total operating expenses | 17,897 | 12,813 | |||||
| Loss from operations | (16,446 | ) | (12,813 | ) | |||
| Other income (expense) | |||||||
| Interest expense | (255 | ) | (1,217 | ) | |||
| Interest and other income (expense), net | 3,714 | 1,296 | |||||
| Gain (loss) from changes in fair value of warrants | 59 | (8 | ) | ||||
| Loss on extinguishment of debt | — | (250 | ) | ||||
| Total other income (expense), net | 3,518 | (179 | ) | ||||
| Net loss | $ | (12,928 | ) | $ | (12,992 | ) | |
| Net loss per share attributable to common stockholders, basic and diluted | $ | (0.36 | ) | $ | (7.76 | ) | |
| Weighted-average common shares outstanding, basic and dilutive | 35,850,037 | 1,673,472 | |||||
| Comprehensive loss: | |||||||
| Net loss | (12,928 | ) | (12,992 | ) | |||
| Other comprehensive income: | |||||||
| Unrealized holding gains on available-for-sale investments | 29 | — | |||||
| Foreign currency translation adjustment | (10 | ) | 21 | ||||
| Total other comprehensive income: | 19 | 21 | |||||
| Total comprehensive loss | $ | (12,909 | ) | $ | (12,971 | ) | |
| BIOAGE LABS, INC. Unaudited Condensed Consolidated Balance Sheets (in thousands, except share and per share information) | |||||||
| March 31, | December 31, | ||||||
| 2025 | 2024 | ||||||
| Assets | |||||||
| Current Assets: | |||||||
| Cash and cash equivalents | $ | 257,486 | $ | 354,349 | |||
| Marketable securities, current | 63,032 | — | |||||
| Accounts receivable | 361 | — | |||||
| Prepaid expenses and other current assets | 3,934 | 2,754 | |||||
| Total current assets | 324,813 | 357,103 | |||||
| Investments | 100 | 100 | |||||
| Marketable securities | 14,559 | — | |||||
| Property and equipment, net | 929 | 591 | |||||
| Operating lease right-of-use assets, net | 3,201 | 200 | |||||
| Other assets | 239 | 240 | |||||
| Total assets | $ | 343,841 | $ | 358,234 | |||
| Liabilities | |||||||
| Current Liabilities: | |||||||
| Accounts payable | $ | 3,989 | $ | 1,996 | |||
| Accrued expenses and other current liabilities | 4,866 | 11,751 | |||||
| Term loan, current | 6,000 | 6,000 | |||||
| Operating lease liabilities, current | 700 | 202 | |||||
| Deferred revenue, current | 8,183 | 7,826 | |||||
| Total current liabilities | 23,738 | 27,775 | |||||
| Deferred revenue | 3,227 | 4,674 | |||||
| Term loan | 1,056 | 2,502 | |||||
| Warrant liability | 97 | 156 | |||||
| Operating lease liabilities | 2,556 | — | |||||
| Total liabilities | 30,674 | 35,107 | |||||
| Commitments and Contingencies (Note 8) | |||||||
| Stockholders’ Equity | |||||||
| Preferred stock, | — | — | |||||
| Common stock, | — | — | |||||
| Additional paid-in-capital | 578,642 | 575,693 | |||||
| Accumulated other comprehensive income | 264 | 245 | |||||
| Accumulated deficit | (265,739 | ) | (252,811 | ) | |||
| Total stockholders’ equity | 313,167 | 323,127 | |||||
| Total liabilities and stockholders’ equity | $ | 343,841 | $ | 358,234 | |||
FAQ
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