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BioArctic collaborator Novartis terminates agreement

BioArctic will keep the full USD 30 million upfront payment despite the collaboration's termination.

(Very High)

Sentiment and the balance of points

Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.

Tags

BioArctic (BIOA B) received notice that Novartis Pharma has decided to terminate their agreement exploring a potential combination treatment. The Option, Collaboration and License Agreement, entered into in August 2025, paired BioArctic's BrainTransporter technology with an undisclosed Novartis antibody. BioArctic said the termination follows Novartis's decision to discontinue the program and is unrelated to BrainTransporter.

BioArctic will retain the full USD 30 million upfront payment and recognize its remaining unrecognized portion as revenue in 2026. The company has entered into five collaboration agreements using BrainTransporter to date.

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2 points · 1 major

How this balance works

Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.

It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.

Rhea-AI Sentiment measures something else, the tone of the wording.

0 major · 1 point

Hollow bars mark forward-looking points. How the balance works

Positive

  • Major point. Forward-looking: it has not happened yet and may not happen.BioArctic will retain the full USD 30 million upfront payment. 11% of market cap
  • Minor point. Forward-looking: it has not happened yet and may not happen.Remaining unrecognized upfront payment will be recognized as revenue in 2026.

Negative

  • Moderate pointNovartis has decided to terminate the August 2025 agreement following its decision to discontinue the program.

Key Figures

Upfront payment retained: USD 30 million
Upfront payment retained
USD 30 million
BioArctic will retain the full payment following termination

Key Terms

transferrin receptor, blood-brain barrier
2 terms
transferrin receptor medical
"using the transferrin receptor (TfR)"
A transferrin receptor is a protein on the surface of many cells that acts like a doorway for iron-carrying transferrin to enter the cell; iron is essential for cell growth and metabolism. Investors watch it because changes in its level or function can indicate disease activity, serve as a biomarker, or be used as a delivery target for drugs and diagnostic agents — think of it as a lock drug makers can exploit to get therapies into specific cells.
blood-brain barrier medical
"transport of medicines across the blood-brain barrier"
A protective barrier of tightly packed cells and supporting tissue that controls what substances in the blood can enter the brain, acting like a security checkpoint that keeps out most pathogens and many drugs while allowing essential nutrients through. For investors, the barrier matters because whether a therapy can cross or safely bypass it often determines clinical success, regulatory approval and commercial potential for treatments of brain disorders.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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STOCKHOLM, Nov. 2, 2026 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) today announced that Novartis Pharma AG has notified BioArctic that it has decided to terminate the Option, Collaboration and License Agreement entered into in August 2025 to explore a potential new treatment combining BioArctic's proprietary BrainTransporter™ technology with an undisclosed Novartis proprietary antibody.

The termination is the result of a Novartis decision to discontinue the program, unrelated to BioArctic's BrainTransporter technology.

BioArctic will retain the full USD 30 million upfront payment and, as a result of the termination, will recognize the remaining unrecognized portion as revenue in 2026.

BioArctic's BrainTransporter technology facilitates the passage of drugs into the brain using the transferrin receptor (TfR). It can be used in a multitude of different therapy areas for delivery of biologics and other modalities to the brain. To date, BioArctic has entered into five collaboration agreements with partners using the BrainTransporter technology.

---

This is information that BioArctic AB (publ) is obliged to disclose pursuant to the EU Market Abuse Regulation. The information was released for public disclosure, through the agency of the contact person below, on November 2, 2026, at 9:30 pm CET.

For further information, please contact: 
Oskar Bosson, Chief Investor Relations & Communications Officer
E-mail: oskar.bosson@bioarctic.com
Telephone: +46 704 107 180

Jenny Ljunggren, External Communications and Investor Relations Manager
E-mail: jenny.ljunggren@bioarctic.com
Telephone: +46 76 013 86 08

About the BrainTransporter™ technology
BioArctic's BrainTransporter technology is a technology for facilitating the passage of drugs into the brain using the transferrin receptor (TfR). Active transport of medicines across the blood-brain barrier can result in broader brain distribution enabling better efficacy, improved safety profile and dosing convenience. The technology is being applied to several in-house drug projects, as well as external collaborations, and could become part of future collaborations with other pharma companies.

About BioArctic AB
BioArctic AB (publ) is a Swedish research-based biopharma company focusing on innovative treatments that can delay or stop the progression of neurodegenerative diseases. The company invented Leqembi® (lecanemab) – the world's first drug proven to slow the progression of the disease and reduce cognitive impairment in early Alzheimer's disease. Leqembi has been developed together with BioArctic's partner Eisai, who are responsible for regulatory interactions and commercialization globally. In addition to Leqembi, BioArctic has a broad research portfolio with antibodies against Parkinson's disease and ALS as well as additional projects against Alzheimer's disease. Several of the projects utilize the company's proprietary BrainTransporter™ technology, which has the potential to actively transport therapies across the blood-brain barrier to enhance the efficacy of the treatment. BioArctic's B share (BIOA B) is listed on Nasdaq Stockholm Large Cap. For further information, please visit www.bioarctic.com.

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/bioarctic/r/bioarctic-collaborator-novartis-terminates-agreement,c4418873

The following files are available for download:

https://mb.cision.com/Main/9978/4418873/4351678.pdf

​​​​​​​BioArctic collaborator Novartis terminates agreement

Cision View original content:https://www.prnewswire.com/news-releases/bioarctic-collaborator-novartis-terminates-agreement-302926959.html

SOURCE BioArctic

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What happens to BioArctic's USD 30 million payment after Novartis terminates the agreement?

BioArctic will retain the full USD 30 million upfront payment and recognize the remaining unrecognized portion as revenue in 2026.

Why did Novartis decide to terminate its BioArctic collaboration?

BioArctic said Novartis decided to discontinue the program for reasons unrelated to BrainTransporter technology. The collaboration explored a potential treatment combining BrainTransporter with an undisclosed Novartis proprietary antibody.

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