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Blueprint Medicines Reports Second Quarter 2024 Results and Raises AYVAKIT®/AYVAKYT® (avapritinib) Full Year Revenue Guidance

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Blueprint Medicines reported strong Q2 2024 results, with AYVAKIT net product revenues of $114.1 million, representing over 185% year-over-year growth. The company raised its full-year 2024 AYVAKIT revenue guidance to $435-$450 million, up from $390-$410 million. Total revenues were $138.2 million for Q2 2024.

Key highlights include:

  • Initiated Phase 1 healthy volunteer trial of wild-type KIT inhibitor BLU-808
  • Presented positive combination safety data for CDK2 inhibitor BLU-222
  • Expects to initiate registration-enabling HARBOR Part 2 study of elenestinib in indolent systemic mastocytosis later this year

Blueprint Medicines reported a net loss of $50.0 million for Q2 2024, compared to $132.8 million in Q2 2023. The company's cash position as of June 30, 2024, was $868.5 million.

Blueprint Medicines ha riportato risultati positivi per il secondo trimestre del 2024, con entrate nette da prodotto AYVAKIT di 114,1 milioni di dollari, che rappresentano oltre il 185% di crescita annua. L'azienda ha innalzato le sue previsioni di entrate per tutto il 2024 per AYVAKIT a 435-450 milioni di dollari, rispetto ai 390-410 milioni di dollari precedentemente stimati. Le entrate totali per il secondo trimestre del 2024 sono state di 138,2 milioni di dollari.

I punti salienti includono:

  • Inizio della sperimentazione di fase 1 con volontari sani per l'inibitore KIT di tipo selvatico BLU-808
  • Presentazione di dati positivi sulla sicurezza della combinazione per l'inibitore CDK2 BLU-222
  • Prevede di avviare lo studio di registrazione HARBOR Parte 2 su elenestinib nella mastocitosi sistemica indolente entro quest'anno

Blueprint Medicines ha riportato una perdita netta di 50,0 milioni di dollari per il secondo trimestre del 2024, rispetto ai 132,8 milioni di dollari del secondo trimestre del 2023. La posizione di cassa della società al 30 giugno 2024 era di 868,5 milioni di dollari.

Blueprint Medicines informó resultados sólidos para el segundo trimestre de 2024, con ingresos netos por productos AYVAKIT de 114.1 millones de dólares, lo que representa un crecimiento de más del 185% en comparación con el año anterior. La compañía elevó su guía de ingresos para AYVAKIT para todo el año 2024 a 435-450 millones de dólares, en comparación con la anterior estimación de 390-410 millones de dólares. Los ingresos totales fueron de 138.2 millones de dólares para el segundo trimestre de 2024.

Los aspectos destacados incluyen:

  • Inicio del ensayo de fase 1 con voluntarios sanos del inhibidor KIT tipo salvaje BLU-808
  • Presentación de datos positivos de seguridad sobre la combinación para el inhibidor CDK2 BLU-222
  • Se espera iniciar el estudio habilitante de registro HARBOR Parte 2 de elenestinib en mastocitosis sistémica indolente más adelante este año

Blueprint Medicines reportó una pérdida neta de 50.0 millones de dólares para el segundo trimestre de 2024, en comparación con 132.8 millones de dólares en el segundo trimestre de 2023. La posición de efectivo de la compañía al 30 de junio de 2024 era de 868.5 millones de dólares.

Blueprint Medicines는 2024년 2분기 우수한 실적을 보고했으며, AYVAKIT의 순제품 수익이 1억 1,410만 달러로 연간 185% 이상의 성장을 나타냈습니다. 회사는 2024년 전체 AYVAKIT 수익 가이던스를 4억 3,500만-4억 5,000만 달러로 상향 조정했으며, 이전의 3억 9,000만-4억 1,000만 달러에서 증가했습니다. 2024년 2분기 총 수익은 1억 3,820만 달러였습니다.

주요 하이라이트:

  • 와일드타입 KIT 억제제 BLU-808의 건강한 자원봉사자에 대한 1상 시험 개시
  • CDK2 억제제 BLU-222에 대한 긍정적 조합 안전성 데이터 발표
  • 올해 말에 느슨한 시스템성 비만세포증에 대한 elenestinib의 등록 허가를 위한 HARBOR 2부 연구를 시작할 것으로 예상됨

Blueprint Medicines는 2024년 2분기에 5천만 달러의 순손실을 보고했으며, 2023년 2분기에는 1억 3,280만 달러였습니다. 2024년 6월 30일 기준 회사의 현금 보유량은 8억 6,850만 달러였습니다.

Blueprint Medicines a annoncé de solides résultats pour le deuxième trimestre 2024, avec des revenus nets de produits AYVAKIT de 114,1 millions de dollars, représentant plus de 185 % de croissance d'une année sur l'autre. L'entreprise a rehaussé ses prévisions de revenus pour AYVAKIT pour l'année 2024 à 435-450 millions de dollars, contre 390-410 millions de dollars auparavant. Les revenus totaux pour le deuxième trimestre 2024 se sont élevés à 138,2 millions de dollars.

Les points clés incluent :

  • Début de l'essai de phase 1 avec des bénévoles en bonne santé pour l'inhibiteur KIT de type sauvage BLU-808
  • Présentation de données positives sur la sécurité de la combinaison pour l'inhibiteur CDK2 BLU-222
  • Prévoit de commencer plus tard cette année l'étude HARBOR Partie 2 pour l'enregistrement de l'elenestinib dans la mastocytose systémique indolente

Blueprint Medicines a annoncé une perte nette de 50,0 millions de dollars pour le deuxième trimestre 2024, contre 132,8 millions de dollars pour le deuxième trimestre 2023. La position de liquidités de l'entreprise au 30 juin 2024 était de 868,5 millions de dollars.

Blueprint Medicines berichtete über starke Ergebnisse im 2. Quartal 2024, mit netto Produktumsätzen von AYVAKIT in Höhe von 114,1 Millionen Dollar, was einem Wachstum von über 185 % im Jahresvergleich entspricht. Das Unternehmen hob seine Umsatzprognose für AYVAKIT für das gesamte Jahr 2024 auf 435-450 Millionen Dollar, von zuvor 390-410 Millionen Dollar. Die Gesamteinnahmen betrugen 138,2 Millionen Dollar im 2. Quartal 2024.

Wichtige Highlights umfassen:

  • Beginn einer Phase-1-Studie mit gesunden Freiwilligen zum Wildtyp-KIT-Inhibitor BLU-808
  • Präsentation positiver Sicherheitsdaten zur Kombination des CDK2-Inhibitors BLU-222
  • Erwartet den Beginn der registrierungsermöglichenden HARBOR Teil 2-Studie zu elenestinib bei indolenter systemischer Mastocytose später in diesem Jahr

Blueprint Medicines vermeldete einen Nettoverlust von 50,0 Millionen Dollar für das 2. Quartal 2024, verglichen mit 132,8 Millionen Dollar im 2. Quartal 2023. Die Liquiditätsposition des Unternehmens am 30. Juni 2024 betrug 868,5 Millionen Dollar.

Positive
  • AYVAKIT net product revenues increased 185% year-over-year to $114.1 million in Q2 2024
  • Raised full-year 2024 AYVAKIT revenue guidance to $435-$450 million
  • Total revenues grew to $138.2 million in Q2 2024, up from $57.6 million in Q2 2023
  • Net loss decreased to $50.0 million in Q2 2024 from $132.8 million in Q2 2023
  • Cash position improved to $868.5 million as of June 30, 2024, up from $767.2 million at end of 2023
Negative
  • Research and development expenses were $84.3 million in Q2 2024
  • Selling, general and administrative expenses increased to $89.3 million in Q2 2024 from $71.9 million in Q2 2023

Insights

Blueprint Medicines' Q2 2024 results showcase impressive growth, particularly in AYVAKIT sales. The company reported $114.1 million in AYVAKIT net product revenues, representing a staggering 185% year-over-year increase. This strong performance has led to an upward revision of the full-year AYVAKIT revenue guidance to $435-450 million, up from the previous $390-410 million range.

The company's overall revenues reached $138.2 million for Q2, a significant jump from $57.6 million in Q2 2023. Despite this growth, Blueprint still reported a net loss of $50 million, though this is a substantial improvement from the $132.8 million loss in the same quarter last year.

Notably, Blueprint's cash position has strengthened, with $868.5 million in cash, cash equivalents and investments as of June 30, 2024, up from $767.2 million at the end of 2023. This increase was primarily due to an additional draw from their 2022 debt facility with Sixth Street Partners.

The company's financial outlook appears positive, with expectations of declining operating expenses and cash burn in 2024 compared to 2023. Blueprint believes its current financial position, combined with anticipated product revenues, will enable it to achieve a self-sustainable financial profile.

While the revenue growth is impressive, investors should note that the company is still operating at a loss. However, the narrowing loss and strong sales growth suggest Blueprint is moving in the right direction financially.

Blueprint Medicines' Q2 results highlight significant progress in their mast cell disorder pipeline. The standout performer, AYVAKIT (avapritinib), has shown remarkable market penetration since its U.S. approval for indolent systemic mastocytosis (ISM) a year ago. The company believes AYVAKIT has the potential to achieve more than $2 billion in peak sales, indicating substantial growth opportunities in the rare disease market.

Beyond AYVAKIT, Blueprint is advancing its mast cell disease franchise with two notable developments:

  • BLU-808, a highly selective and potent wild-type KIT inhibitor, has entered Phase 1 trials with healthy volunteers. This compound shows promise for chronic urticaria and other mast cell disorders, potentially expanding Blueprint's reach in this therapeutic area.
  • Elenestinib, a next-generation KIT D816V inhibitor, is poised to enter the registration-enabling HARBOR Part 2 study for ISM later this year, further solidifying Blueprint's position in systemic mastocytosis treatment.

The company also presented data on BLU-222, an oral CDK2 inhibitor, in combination with ribociclib and fulvestrant for HR+/HER2- breast cancer. This marks the first positive combination safety data for a CDK2 inhibitor in this setting, potentially opening new avenues in cell cycle inhibition therapies.

These advancements demonstrate Blueprint's commitment to expanding its pipeline beyond AYVAKIT, which could help mitigate risks associated with reliance on a single product. However, the success of these new compounds in later-stage trials and their potential market impact remain to be seen.

-- Achieved $114.1 million in AYVAKIT net product revenues in the second quarter 2024 --

-- Raising AYVAKIT net product revenue guidance to $435 million to $450 million for 2024 --

-- Initiated Phase 1 healthy volunteer trial of wild-type KIT inhibitor BLU-808 --

CAMBRIDGE, Mass., Aug. 1, 2024 /PRNewswire/ -- Blueprint Medicines Corporation (Nasdaq: BPMC) today reported financial results, provided a business update for the second quarter ended June 30, 2024, and provided updated financial guidance.

"This quarter marks a milestone, as we celebrate one full year since the U.S. approval of AYVAKIT for indolent systemic mastocytosis. We have delivered yet another very strong quarter of revenue as we continue to build this new rare disease market, and we are well on the path to achieve more than $2 billion in potential peak sales. In addition, we have invested in our next pillars of growth, building on AYVAKIT as the cornerstone of a mast cell disease franchise. Our wild-type KIT inhibitor BLU-808 has entered a Phase 1 healthy volunteer study and we expect to initiate the registration-enabling HARBOR Part 2 study of our next-generation KIT D816V inhibitor elenestinib in indolent systemic mastocytosis later this year," said Kate Haviland, Chief Executive Officer of Blueprint Medicines. "With a significant and growing revenue base from AYVAKIT, a next wave of therapies in our pipeline that we believe can address even larger scale patient opportunities, and a financial profile anchored in sustainable topline revenue growth that enables us the flexibility to invest in the next wave of innovation, we are building Blueprint Medicines for long term value."

Second Quarter 2024 Highlights and Recent Progress

Mast cell disorders

  • Achieved AYVAKIT net product revenues of $114.1 million for second quarter of 2024, representing more than 185 percent growth year-over-year.
  • Achieved clearance of an Investigational New Drug application for BLU-808 by the U.S. Food and Drug Administration and initiated the healthy volunteer study. BLU-808 is a highly selective and potent investigational oral wild-type KIT inhibitor with best-in-class potential, for chronic urticaria and other mast cell disorders.
  • Presented multiple datasets highlighting the long-term safety and durable clinical outcomes of AYVAKIT®/AYVAKYT® (avapritinib) across the spectrum of systemic mastocytosis (SM) at the 2024 European Academy of Allergy and Clinical Immunology (EAACI) and European Hematology Association (EHA) conferences.  Read the presentations here.

Cell cycle inhibition

  • Presented data from the Phase 1 VELA study of BLU-222, an oral, potent and selective CDK2 inhibitor, at the 2024 American Society of Clinical Oncology (ASCO) meeting. This is the first positive combination safety data with signals of early clinical activity for a CDK2 inhibitor in combination with an approved CDK4/6 inhibitor, ribociclib, and fulvestrant, in patients with HR+/HER2- breast cancer. Read the presentation here.

2024 Financial Guidance

Blueprint Medicines now anticipates approximately $435 million to $450 million in global AYVAKIT net product revenues for all approved indications in 2024, an increase from the previous range of $390 million to $410 million. The company continues to expect that full-year operating expenses and cash burn will decline in 2024 as compared to 2023, and that its existing cash, cash equivalents and investments, together with anticipated product revenues, will enable the company to maintain a durable capital position to achieve a self-sustainable financial profile.

Key Upcoming Milestones

The company plans to achieve the following remaining milestones in the second half of 2024:

Mast cell disorders

  • Initiate registration-enabling Part 2 of the HARBOR trial in indolent systemic mastocytosis (ISM).

Cell cycle inhibition

  • Continue strategic business development discussions.
  • Complete Phase 1 combination dose escalation for BLU-222 by end of year to inform registration plans.

Second Quarter 2024 Results

  • Revenues: Revenues were $138.2 million for the second quarter of 2024, including $114.1 million of net product revenues from sales of AYVAKIT/AYVAKYT and $24.0 million in collaboration, license and other revenues. Revenues were $57.6 million in the second quarter of 2023, including $39.9 million of net product revenues from sales of AYVAKIT/AYVAKYT and $17.7 million in collaboration, license and other revenues. 
  • Cost of Sales: Cost of sales was $7.6 million for the second quarter of 2024, as compared to $2.3 million for the second quarter of 2023. The increase was primarily due to the sale of GAVRETO® (pralsetinib) product to Rigel.
  • R&D Expenses: Research and development expenses were $84.3 million for the second quarter of 2024, as compared to $110.1 million for the second quarter of 2023. This decrease was primarily due to operational efficiency across our portfolio as we execute across our top priority programs and the timing of manufacturing of clinical trial materials. Research and development expenses included $12.3 million in stock-based compensation expenses for the second quarter of 2024.
  • SG&A Expenses: Selling, general and administrative expenses were $89.3 million for the second quarter of 2024, as compared to $71.9 million for the second quarter of 2023. This increase was primarily due to an increase in activities supporting the commercialization of AYVAKIT/AYVAKYT. Selling, general, and administrative expenses included $15.7 million in stock-based compensation expenses for the second quarter of 2024.
  • Net Loss: Net loss was $50.0 million for the second quarter of 2024, as compared to a net loss of $132.8 million for the second quarter of 2023.
  • Cash Position: As of June 30, 2024, cash, cash equivalents and investments were $868.5 million, as compared to $767.2 million as of December 31, 2023. This increase was primarily due to taking an additional draw under our 2022 debt facility with Sixth Street Partners. Blueprint Medicine's cash and investments provide a durable capital position which, together with anticipated product revenues, the company believes will enable it to reach a self-sustainable financial profile.

Conference Call Information

Blueprint Medicines will host a live conference call and webcast at 8:00 a.m. ET today to discuss second quarter 2024 financial results and recent business activities. The conference call may be accessed by dialing 833-470-1428 (domestic) or 404-975-4839 (international), and referring to conference ID 299779. A webcast of the call will also be available under "Events and Presentations" in the Investors & Media section of the Blueprint Medicines website at http://ir.blueprintmedicines.com/. The archived webcast will be available on Blueprint Medicines' website approximately two hours after the conference call and will be available for 30 days following the call.

Upcoming Investor Conferences

Blueprint Medicines will participate in two upcoming investor conferences:

  • Morgan Stanley 22nd Annual Global Healthcare Conference on Thursday, September 5, 2024 at 1:50 p.m. ET.
  • 2024 Wells Fargo Healthcare Conference on Thursday, September 5, 2024 at 11:00 a.m. ET.

A live webcast of the fireside discussions will be available under "Events and Presentations" in the Investors & Media section of the Blueprint Medicines website at http://ir.blueprintmedicines.com. A replay of the webcasts will be archived on the Blueprint Medicines website for 30 days following the events.

About Blueprint Medicines

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a track record of success with two approved medicines, including AYVAKIT®/AYVAKYT® (avapritinib) which we are bringing to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors. For more information, visit www.BlueprintMedicines.com and follow us on X (formerly Twitter; @BlueprintMeds) and LinkedIn.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, statements regarding plans, strategies, timelines and expectations for Blueprint Medicines' operations, including its expectations regarding growth and product revenue in 2024; statements regarding our current or future approved drugs and drug candidates and operations, including AYVAKIT's potential to achieve more than $2 billion in peak sales; plans to initiate registration-enabling Part 2 of the HARBOR trial in ISM, complete Phase 1 combination dose escalation for BLU-222 to inform registration plans and continue strategic business development discussions all in the second half of 2024; plans to advance our portfolio by targeting additional allergic-inflammatory diseases driven by mast cells; expectations related to the markets for our current or future approved drugs and drug candidates, including expectations regarding the size or scale of patient opportunities that our future approved drugs and drug candidates could address; the potential benefits of any of our current or future approved drugs or drug candidates in treating patients; statements related to our liquidity and capital position, including expectations that our cash, cash equivalents and investments will provide a durable capital position which, together with anticipated product revenues, will enable us to reach a self-sustainable financial profile; and our financial performance, strategy, goals and anticipated milestones, business plans and focus, including expectations regarding our revenue ramp and continued decline in operating expenses and cash burn. The words "aim," "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation: the risk that the marketing and sale of AYVAKIT/ AYVAKYT or any future approved drugs may be unsuccessful or less successful than anticipated, or that AYVAKIT/ AYVAKYT may not gain market acceptance by physicians, patients, third-party payors and others in the medical community; the risk that the market opportunities for AYVAKIT/ AYVAKYT or our drug candidates are smaller than we estimate or that any approval we obtain may be based on a narrower definition of the patient population that we anticipate; the risk of delay of any current or planned clinical trials or the development of Blueprint Medicines' current or future drug candidates; risks related to Blueprint Medicines' ability to successfully demonstrate the safety and efficacy of its drug candidates and gain approval of its drug candidates on a timely basis, if at all; preclinical and clinical results for Blueprint Medicines' drug candidates may not support further development of such drug candidates either as monotherapies or in combination with other agents or may impact the anticipated timing of data or regulatory submissions; the timing of the initiation of clinical trials and trial cohorts at clinical trial sites and patient enrollment rates may be delayed or slower than anticipated; actions of regulatory agencies may affect our approved drugs or our current or future drug candidates, including affecting the initiation, timing and progress of clinical trials; risks related to Blueprint Medicines' ability to obtain, maintain and enforce patent and other intellectual property protection for its products and current or future drug candidates it is developing; the success of Blueprint Medicines' current and future collaborations, financing arrangements, partnerships or licensing and other arrangements; risks related to our liquidity and financial position, including the risk that we may be unable to generate sufficient future product revenues to achieve and maintain a self-sustainable financial profile; and the accuracy of our estimates of revenues, expenses and capital requirements. These and other risks and uncertainties are described in greater detail in the section entitled "Risk Factors" in Blueprint Medicines' filings with the Securities and Exchange Commission (SEC), including Blueprint Medicines' most recent Annual Report on Form 10-K, as supplemented by its most recent Quarterly Report on Form 10-Q and any other filings that Blueprint Medicines has made or may make with the SEC in the future. Any forward-looking statements contained in this press release represent Blueprint Medicines' views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Except as required by law, Blueprint Medicines explicitly disclaims any obligation to update any forward-looking statements.

Trademarks

Blueprint Medicines, AYVAKIT, AYVAKYT and associated logos are trademarks of Blueprint Medicines Corporation.
GAVRETO and associated logos are trademarks of Blueprint Medicines Corporation outside of the United States. 

Blueprint Medicines Corporation

Selected Condensed Consolidated Balance Sheet Data

(in thousands)

(unaudited)










June 30,


December 31,



2024


2023

Cash, cash equivalents and investments

$

868,471


$

767,171

Working capital (1)


659,741



593,470

Total assets


1,203,560



1,049,250

Deferred revenue (2)


11,789



5,604

Liability related to the sale of future royalties and revenues (2)


265,533



441,625

Term loan (2)


386,914



238,813

Total liabilities


883,319



918,641

Total stockholders' equity


320,241



130,609



(1)

Blueprint Medicines defines working capital as current assets less current liabilities.

(2)

Includes both current and long-term portions of the balance.

 

Blueprint Medicines Corporation

Condensed Consolidated Statements of Operations Data

(in thousands, except per share data)

(unaudited)

















Three Months Ended


Six Months Ended



June 30, 


June 30, 



2024


2023


2024


2023

Revenues:













Product revenue, net


$

114,115


$

39,876


$

206,641


$

78,945

Collaboration and license and other revenue



24,042



17,694



27,632



41,912

Total revenues



138,157



57,570



234,273



120,857

Cost and operating expenses:













Cost of sales



7,593



2,323



10,785



5,498

Collaboration loss sharing





1,234





2,530

Research and development



84,270



110,063



172,461



222,135

Selling, general and administrative



89,339



71,931



172,896



142,882

Total cost and operating expenses



181,202



185,551



356,142



373,045

Other income (expense):













Interest expense, net



(6,864)



(3,996)



(12,760)



(9,815)

Other income (expense), net



(1)



(626)



376



359

Debt extinguishment gain



18





173,676



Total other income (expense), net



(6,847)



(4,622)



161,292



(9,456)

Income (loss) before income taxes



(49,892)



(132,603)



39,423



(261,644)

Income tax expense



102



190



282



710

Net Income (loss)


$

(49,994)


$

(132,793)


$

39,141


$

(262,354)

Net income (loss) per share — basic


$

(0.80)


$

(2.19)


$

0.63


$

(4.35)

Net income (loss) per share — diluted


$

(0.80)


$

(2.19)


$

0.61


$

(4.35)

Weighted-average number of common shares used in net income (loss) per share — basic



62,854



60,516



62,217



60,322

Weighted-average number of common shares used in net income (loss) per share —diluted



62,854



60,516



64,612



60,322

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SOURCE Blueprint Medicines Corporation

FAQ

What was Blueprint Medicines' AYVAKIT revenue in Q2 2024?

Blueprint Medicines reported AYVAKIT net product revenues of $114.1 million in Q2 2024, representing over 185% year-over-year growth.

Has Blueprint Medicines (BPMC) updated its 2024 revenue guidance for AYVAKIT?

Yes, Blueprint Medicines raised its full-year 2024 AYVAKIT revenue guidance to $435-$450 million, up from the previous range of $390-$410 million.

What is the status of Blueprint Medicines' (BPMC) BLU-808 development?

Blueprint Medicines has initiated a Phase 1 healthy volunteer trial of BLU-808, a wild-type KIT inhibitor for chronic urticaria and other mast cell disorders.

What was Blueprint Medicines' (BPMC) net loss in Q2 2024?

Blueprint Medicines reported a net loss of $50.0 million for Q2 2024, compared to a net loss of $132.8 million for Q2 2023.

Blueprint Medicines Corporation

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