Welcome to our dedicated page for Can-Fite BioPharma Ltd. news (Ticker: CANF), a resource for investors and traders seeking the latest updates and insights on Can-Fite BioPharma Ltd. stock.
Can-Fite BioPharma Ltd. (CANF) is a clinical-stage biotechnology company whose news flow centers on the development of orally administered small-molecule drugs targeting the A3 adenosine receptor. On this page, readers can follow company announcements on clinical trial progress, regulatory designations, patent developments, financing events, and corporate actions related to its oncology, liver disease, inflammatory, and sexual dysfunction programs.
Recent news has highlighted pivotal and mid-stage clinical studies, including a Phase III trial of Namodenoson in advanced hepatocellular carcinoma, a Phase IIb trial in MASH, and a Phase IIa study in pancreatic cancer. The company has also reported compassionate use cases in advanced liver disease and cirrhosis, as well as long-term survival outcomes in liver cancer patients treated with Namodenoson. For Piclidenoson, updates include Phase III psoriasis development and protocol preparation for rare diseases such as Lowe Syndrome, along with preclinical findings in vascular dementia models.
News items also cover CF602, an A3AR allosteric modulator in development for erectile dysfunction, including patent allowances and grants in markets such as Brazil, the United States, and Europe. Can-Fite regularly reports on its intellectual property strategy, out-licensing and distribution agreements for human and veterinary indications, participation in industry conferences, and capital markets activities such as public offerings, warrant amendments, and share structure changes like reverse splits and ADS ratio adjustments.
Investors and observers can use this CANF news feed to monitor key milestones that may affect the company’s clinical pipeline, regulatory interactions, partnering discussions, and financial position over time.
Can-Fite BioPharma Ltd (NYSE American: CANF) received clearance from the Israeli Ministry of Health to initiate a Phase IIb study of its drug candidate Namodenoson for treating NASH. Enrollment is expected to start in Q3 2021, earlier than previously anticipated. The study aims to assess Namodenoson's efficacy in 140 subjects, comparing its effects against a placebo over 36 weeks. Given the urgent unmet medical need for NASH treatments, the market for NASH pharmaceuticals could reach $35-40 billion by 2025.
Can-Fite BioPharma Ltd. (NYSE American: CANF) announces that Dr. Sari Fishman will present at the BIO Digital Convention on June 10-11 & 14-18, 2021. Can-Fite has secured approximately $20 million from out-licensing agreements for its drug candidates, with potential milestone payments of up to $130 million. The company anticipates key developments, including topline data from Phase III psoriasis and Phase II COVID-19 trials, as well as initiating pivotal trials in liver cancer and NASH by year-end.
Can-Fite BioPharma Ltd (NYSE American: CANF) reported its financial results for Q1 2021, revealing revenues of $0.15 million, down 25.2% from $0.20 million in Q1 2020. The company secured a $42.7 million out-licensing deal with Ewopharma, including $2.25 million upfront and up to $40.45 million contingent on milestones. The Phase III Comfort™ psoriasis study reached 75% enrollment, with topline results anticipated in Q4 2021. Can-Fite’s R&D expenses declined by 65.5% to $1.30 million, while general and administrative expenses rose to $1.01 million. Future trials for liver cancer and NASH are set for late 2021.
Can-Fite BioPharma Ltd. (NYSE American: CANF) announced that CEO Dr. Pnina Fishman will appear on The RedChip Money Report on May 29th, at 7 p.m. local time, reaching 73 million homes in the U.S. The interview will cover upcoming milestones and updates on Can-Fite's drug pipeline, including Piclidenoson and Namodenoson, which target conditions like psoriasis and liver cancer. Piclidenoson is in Phase III trials for psoriasis and Phase II studies for COVID-19, while Namodenoson has shown promise in treating liver cancer and has received Orphan Drug Designation.
Can-Fite BioPharma Ltd (NYSE American: CANF) will present at Benzinga’s Global SmallCap Conference on May 13, 2021. CEO Dr. Pnina Fishman will discuss the company’s advancements in treating psoriasis, liver cancer, and NASH. Can-Fite's drug candidates are in Phase II and Phase III trials, showcasing clinical proof of concept. The company’s lead drug, Piclidenoson, targets moderate COVID-19, while Namodenoson is set for Phase III for hepatocellular carcinoma and has received Orphan Drug and Fast Track Designation from the FDA.
Can-Fite BioPharma Ltd (NYSE American: CANF) reported that 75% of patients have been enrolled in its Phase III Comfort™ study for Piclidenoson, targeting moderate to severe plaque psoriasis. The study aims to establish the drug's superiority over placebo and non-inferiority to Apremilast, with enrollment expected to finalize in Q3 2021 and topline results anticipated in Q4 2021. The company has received over $20 million from distribution agreements for Piclidenoson, which is out-licensed in several countries. The psoriasis therapeutic market is projected to hit $11.3 billion by 2025.
Can-Fite BioPharma Ltd (NYSE American: CANF) expands its Phase II COVID-19 study of Piclidenoson to Romania and Bulgaria. The randomized, double-blind study evaluates Piclidenoson with standard care versus placebo in hospitalized patients. The treatment duration is up to 28 days, with assessments at Day 29 focusing on respiratory status and safety. Piclidenoson shows promise due to its anti-inflammatory effects and potential to combat COVID-19's severity. The CEO emphasizes the drug's safety and efficacy as recruitment accelerates in Europe.
Can-Fite BioPharma (NYSE American: CANF) announced the initiation of preclinical studies for its drug candidates Piclidenoson and Namodenoson, in preparation for future NDA and MAA submissions to the FDA and EMA. Piclidenoson is currently in the COMFORT Phase III study for psoriasis, while Namodenoson, which has Orphan Drug and Fast Track Status, will begin a Phase III study for hepatocellular cancer by Q4 2021. The company aims to obtain marketing approvals for both drugs, addressing significant market needs.
Can-Fite BioPharma Ltd (NYSE American: CANF) announced successful pre-clinical studies showing that a CBD-rich T3/C15 cannabis fraction inhibits liver cancer cell growth. This mechanism targets the A3 adenosine receptor (A3AR), crucial in liver cancer treatment. The company’s drug candidate Namodenoson is set to enter a Phase III study for advanced liver cancer in Q4 2021. The global medical cannabis market is projected to grow to $56.7 billion by 2026, highlighting significant market opportunities for Can-Fite’s cannabinoid-based therapies.
Can-Fite BioPharma Ltd. (NYSE American: CANF) has announced that its six distribution agreements for drug candidates Piclidenoson and Namodenoson could yield up to $130 million in milestone payments, alongside double-digit royalties on net sales. The company has already secured over $20 million in non-dilutive upfront and milestone payments. Territories covered include Canada, Spain, Switzerland, and more, with further discussions targeting larger markets like the U.S. and Japan. CEO Dr. Pnina Fishman emphasized the strategic growth potential in untapped markets.