Welcome to our dedicated page for Cellectis S.A. news (Ticker: CLLS), a resource for investors and traders seeking the latest updates and insights on Cellectis S.A. stock.
Cellectis S.A. (symbol: CLLS) is a clinical-stage biopharmaceutical company that specializes in developing cutting-edge cancer immunotherapies using gene-edited T-cells, known as UCART. With over 18 years of experience in gene editing, Cellectis leverages its proprietary TALEN® technology and PulseAgile electroporation system to harness the power of the immune system to combat cancer.
Cellectis is dedicated to creating innovative products in the fields of immuno-oncology and beyond. Its portfolio includes allogeneic Chimeric Antigen Receptor T-cells (CAR-T) product candidates and gene-edited hematopoietic stem and progenitor cells (HSPC) for various therapeutic applications.
Recent achievements include advancements in gene correction and gene insertion technologies, presented at esteemed scientific conferences. For instance, the company has introduced a novel method for circularizing non-viral single-strand DNA templates, enhancing gene editing outcomes in HSPCs. Cellectis is also collaborating with renowned pharmaceutical companies like AstraZeneca, further expanding its pipeline of allogeneic CAR T-cell therapies.
Financially, Cellectis is listed on both the NASDAQ (ticker: CLLS) and the NYSE Alternext (ticker: ALCLS) markets. The company's ongoing projects and research efforts are supported by robust investment and partnership agreements, showcasing its commitment to improving health outcomes through innovative biotechnological solutions.
For more information, visit the company's website at www.cellectis.com.
Cellectis (NASDAQ: CLLS) announced that the FDA has granted Orphan Drug (ODD) and Rare Pediatric Disease Designation (RPDD) Status to its UCART22 product candidate for treating Acute Lymphoblastic Leukemia (ALL). ALL represents 10% of leukemia cases in the US, progressing rapidly and often fatal if untreated. The designations highlight UCART22's potential to address urgent needs in ALL treatment, especially for patients ineligible for stem cell transplantation or relapsing after other therapies.
UCART22, an allogeneic CAR T-cell therapy, is being evaluated in the BALLI-01 Phase 1/2 study. Recent data showed a 67% preliminary response rate at Dose Level 2 for UCART22-P2, manufactured by Cellectis. The company expects to provide updates on BALLI-01 by year-end 2024. These FDA designations may expedite development and reduce costs for UCART22.
On July 5, 2024, Cellectis provided an update on its share capital and voting rights as required by Article 223-16 of the French financial markets authority.
The company, listed on the Euronext Growth market under ISIN code FR0010425595, reported a total of 100,093,635 shares in its capital as of June 30, 2024.
The total number of voting rights for the same period was 88,029,364.
For any queries, media can contact Pascalyne Wilson, Director of Communications, or Patricia Sosa Navarro, Chief of Staff to the CEO. Investor relations are managed by Arthur Stril, Interim CFO, and Ashley R. Robinson from LifeSci Advisors.
Cellectis, a clinical-stage biotechnology company listed on Euronext Growth (ALCLS) and Nasdaq (CLLS), held its shareholders' general meeting on June 28, 2024, in Paris. Approximately 40% of shares were exercised during the meeting, resulting in the adoption of resolutions 1 through 28 and the rejection of resolution 29, aligning with management's recommendations. Detailed voting results and resolutions are accessible on Cellectis' official website.
Cellectis, a clinical-stage biotechnology company, has published a scientific article in Scientific Reports, revealing three key factors for efficient TALE base editing. This gene-editing technology, which does not create DNA breaks like CRISPR/Cas9, holds promise for treating genetic diseases by converting cytosine (C) to thymine (T). The study identifies spacer length, TALEB architecture, and surrounding base composition as critical elements for enhancing editing efficiency. This research deepens the understanding of TALE base editors, potentially expanding their therapeutic applications. The full article is available on the Scientific Reports website.
Cellectis announced a breakthrough in gene therapy for Sickle Cell Disease (SCD) using a non-viral approach published in Nature Communications. The therapy employs TALEN® technology for precise HBB gene correction in hematopoietic stem and progenitor cells (HSPCs). This method achieves over 50% expression of normal hemoglobin in treated cells, effectively correcting the sickle cell phenotype without adverse effects. The preclinical data shows promising therapeutic potential and efficient engraftment in animal models, indicating readiness for clinical application. This innovative approach offers hope for addressing SCD and other genetic diseases.
Cellectis has released its monthly update on share capital and voting rights as of May 31, 2024. The company, listed on Euronext Growth with ISIN code FR0010425595, reports a total of 100,093,635 shares in its capital. The number of voting rights stands at 88,029,374. For more details, media and investor relations contacts are provided.
Cellectis announced that the European Commission granted Orphan Drug Designation (ODD) to UCART22, its allogeneic CAR T product for treating Acute Lymphoblastic Leukemia (ALL).
UCART22 targets CD22 and is being evaluated in the Phase 1/2 BALLI-01 study, focusing on patients with relapsed/refractory ALL.
ALL accounts for 12% of all leukemia cases and progresses rapidly. The 10-year prevalence in the EU is estimated at 1.9 per 100,000 persons.
The ODD was based on preliminary clinical data showing UCART22's significant benefit in heavily pretreated patients. In December 2023, Cellectis reported encouraging data with a 67% response rate at Dose Level 2 for UCART22-P2.
ODD provides regulatory, financial, and commercial incentives.
Cellectis (Euronext Growth: ALCLS, NASDAQ: CLLS), a clinical-stage biotechnology company, will hold its annual general meeting on June 28, 2024, at 2:30 p.m. CET.
The meeting will take place at the Biopark auditorium, 11 rue Watt, 4th floor, 75013 Paris, France.
Details regarding the agenda and participation are available on the Cellectis website.
Cellectis reported its Q1 2024 financial results revealing key business updates and financial highlights. Key points include:
Completion of a $140M equity investment by AstraZeneca, pushing the company's cash position to $143M as of March 31, 2024, and extending its cash runway projection into 2026.
Revenues for Q1 2024 were $6.5M, a significant increase from $3.6M in Q1 2023.
R&D expenses rose to $22.3M from $21.1M, while SG&A expenses were relatively stable at $5.1M.
The company recorded a consolidated net income of $5.6M, compared to a net loss of $30.1M in Q1 2023.
Key clinical programs BALLI-01, NATHALI-01, and AMELI-01 continue to progress with updates expected by year-end 2024.
The appointment of Arthur Stril as Interim CFO was announced, and AstraZeneca now owns approximately 44% of Cellectis' share capital.
Cellectis (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company specializing in gene-editing platform technologies, will announce its first quarter 2024 financial results on May 28, 2024, after the US market closes. The results will cover the period ending March 31, 2024. Following the announcement, the Company will hold an investor conference call and webcast on May 29, 2024, at 8:00 AM ET / 2:00 PM CET to discuss the financial results and provide an update on business activities. Investors and stakeholders can join the call using the provided domestic and international dial-in numbers or access the webcast online.
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