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Clearmind Medicine Announces Hong Kong Patent Filing for Depression Therapy

Clearmind Medicine (Nasdaq: CMND) on March 13, 2026 filed a patent application with Hong Kong IPD for a combination therapy pairing proprietary MEAI with Palmitoylethanolamide (PEA) to treat major depressive disorder (MDD).

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Clearmind Medicine (Nasdaq: CMND) on March 13, 2026 filed a patent application with Hong Kong IPD for a combination therapy pairing proprietary MEAI with Palmitoylethanolamide (PEA) to treat major depressive disorder (MDD).

The filing notes the PEA supply via a partnership with NeuroThera Labs (TSXV: NTLX), a SciSparc subsidiary, and positions the MEAI-PEA synergy as a non-hallucinogenic neuroplastogen approach targeting an MDD market projected above $25 billion by 2030.

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Argus Mar 13 session
-5.88% close to close Open Argus
Details

News Market Reaction – CMND

On Mar 13, the day this news came out, CMND closed 5.88% below the previous close.

Data tracked by StockTitan Argus for the Mar 13 session.

Key Figures

Depression market size: $25 billion Depression prevalence: more than 332 million people
Depression market size
$25 billion
Global depression therapy market expected to surpass by 2030
Depression prevalence
more than 332 million people
Global population affected by depression referenced in patent release

Historical Context

5 past events · Latest: Mar 11
5 events
  1. Mar 11

    Trial enrollment update

    24h Move
    -6.3%

    Continued enrollment for CMND-100 Cohort 3 after positive Cohort 2 data.

  2. Mar 10

    Patent publication

    24h Move
    -2.0%

    International PCT patent publication for MEAI-PEA therapy targeting weight loss and MASLD.

  3. Mar 4

    DSMB trial review

    24h Move
    -4.8%

    DSMB cleared CMND-100 trial to advance to third cohort with 80 mg dosing.

  4. Feb 19

    Promotional overview

    24h Move
    +4.2%

    Paid media review highlighting MEAI and GLP‑1 as next‑generation weight-loss approaches.

  5. Feb 9

    Safety data update

    24h Move
    -8.2%

    Additional positive safety topline results from CMND-100 second cohort in Phase I/IIa trial.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Key Terms

major depressive disorder, palmitoylethanolamide, ssris, neuroplastogen, +1 more
5 terms
major depressive disorder medical
"therapy designed to treat major depressive disorder (MDD)."
A clinical condition characterized by persistent, severe low mood, loss of interest in daily activities, and reduced ability to function at work or home, lasting weeks or longer. It matters to investors because it drives demand for treatments and mental health services, affects workforce productivity and absenteeism, influences health-care and insurance costs, and shapes risks and opportunities for companies developing drugs, therapies or workplace programs—like a long-lasting storm that lowers economic output.
palmitoylethanolamide medical
"blends Clearmind’s proprietary 5-methoxy-2-aminoindane (MEAI) with Palmitoylethanolamide (PEA)"
Palmitoylethanolamide (PEA) is a naturally occurring fatty molecule produced in the body and sold as a supplement or experimental therapy for reducing pain and inflammation; think of it as a built‑in calming signal that helps quiet irritated tissues. Investors watch PEA because its potential medical benefits, regulatory path (supplement vs. drug), and clinical evidence drive market demand, pricing and the risk/reward of companies developing or selling PEA-based products — similar to how a promising ingredient can change the fortunes of a consumer brand.
ssris medical
"alternative to existing antidepressants, including SSRIs and other conventional options."
Selective serotonin reuptake inhibitors (SSRIs) are a class of prescription medicines that raise levels of the brain chemical serotonin by preventing its reabsorption into nerve cells. Think of them like closing a small drain so more water stays in a bathtub: they help mood-regulating signals last longer. Investors watch SSRIs because their sales, patent status, safety data and prescribing trends can strongly affect drugmakers’ revenue and regulatory risk.
neuroplastogen medical
"non-hallucinogenic, second generation, neuroplastogen-derived therapeutics to solve major"
A neuroplastogen is a drug or compound designed to boost the brain’s ability to rewire and form new connections, enhancing recovery or adaptation after injury, stress, or disease. For investors, these molecules matter because they target underlying brain repair processes rather than just masking symptoms, offering the potential for durable benefits in conditions like depression, neurodegeneration, or cognitive decline—akin to giving a tired garden fresh tools to regrow and reshape itself.
major depressive disorder (mdd) medical
"therapy designed to treat major depressive disorder (MDD)."
Major depressive disorder (MDD) is a clinical mental-health condition characterized by persistent low mood, loss of interest in usual activities, and changes in sleep, appetite, energy, and concentration that significantly impair daily functioning for weeks or longer. It matters to investors because MDD drives healthcare spending, shapes demand for treatments, affects workforce productivity and absenteeism, and influences the commercial and regulatory prospects of companies developing therapies—like a chronic engine problem that reduces output and raises repair costs.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Innovative non-hallucinogenic approach combines MEAI with Palmitoylethanolamide to tackle major depressive disorder, addressing a surging market expected to surpass $25 billion by 2030

Vancouver, Canada, March 13, 2026 (GLOBE NEWSWIRE) -- Clearmind Medicine Inc. (Nasdaq: CMND), (FSE: CWY0) (“Clearmind” or the "Company"), a clinical-stage biotech company focused on the discovery and development of novel, non-hallucinogenic, second generation,  neuroplastogen-derived therapeutics to solve major under-treated health problems, today announced the filing of a patent application with the Intellectual Property Department (IPD) in Hong Kong, for am innovative combination therapy designed to treat major depressive disorder (MDD).

This innovative treatment blends Clearmind’s proprietary 5-methoxy-2-aminoindane (MEAI) with Palmitoylethanolamide (PEA), sourced via its partnership with NeuroThera Labs Inc. (TSXV: NTLX), a subsidiary of SciSparc Ltd. (Nasdaq: SPRC).

The patent filing underscores the potential promise of this MEAI-PEA synergy as a non-hallucinogenic neuroplastogen option for combating depression, a condition affecting more than 332 million people globally. Given the anticipated mechanism of action, this therapy could provide a more accessible, safer, and affordable alternative to existing antidepressants, including SSRIs and other conventional options.

About Clearmind Medicine Inc.

Clearmind is a clinical-stage neuroplastogens pharmaceutical biotech company focused on the discovery and development of novel psychedelic-derived therapeutics to solve widespread and underserved health problems, including alcohol use disorder. Its primary objective is to research and develop psychedelic-based compounds and attempt to commercialize them as regulated medicines, foods, or supplements.

The Company’s intellectual portfolio currently consists of nineteen patent families, including 31 granted patents. The Company intends to seek additional patents for its compounds whenever warranted and will remain opportunistic regarding the acquisition of additional intellectual property to build its portfolio.

Shares of Clearmind are listed for trading on Nasdaq under the symbol "CMND."

For further information, visit: https://www.clearmindmedicine.com or contact:

Investor Relations
invest@clearmindmedicine.com
Telephone: (604) 260-1566
US: CMND@crescendo-ir.com

General Inquiries
Info@Clearmindmedicine.com
www.Clearmindmedicine.com

Forward-Looking Statements:

This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses how the patent filing underscores the potential promise of this MEAI-PEA synergy as a non-hallucinogenic neuroplastogen option for combating depression and how the Company intends to seek additional patents for its compounds whenever warranted and will remain opportunistic regarding the acquisition of additional intellectual property to build its portfolio. The Company cannot assure that any patent will issue as a result of a pending patent application or, if issued, whether it will issue in a form that will be advantageous to the Company. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission (“SEC”), including, but not limited to, the risks detailed in the Company’s annual report on Form 20-F for the fiscal year ended October 31, 2025 and subsequent filings with the SEC. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. Clearmind is not responsible for the contents of third-party websites.


FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did Clearmind (CMND) file in Hong Kong on March 13, 2026?

Clearmind filed a patent application for a MEAI plus PEA combination therapy to treat MDD. According to Clearmind, the filing covers a proprietary non-hallucinogenic neuroplastogen pairing sourcing PEA via a partnership with NeuroThera Labs (TSXV: NTLX).

How does the MEAI-PEA therapy announced by CMND aim to treat depression?

The therapy aims to deliver non-hallucinogenic neuroplastic effects to address MDD symptoms. According to Clearmind, the MEAI-PEA synergy is intended to provide an accessible, safer, and affordable alternative to SSRIs and conventional antidepressants.

What commercial partners are involved in Clearmind's Hong Kong patent filing (CMND)?

Clearmind cites PEA sourced through a partnership with NeuroThera Labs, a SciSparc subsidiary. According to Clearmind, that sourcing relationship underpins the combination therapy disclosed in the Hong Kong patent application.

Does Clearmind's Hong Kong patent filing (CMND) mean the therapy is approved for use?

No, a patent filing does not equal regulatory approval or market authorization. According to Clearmind, the filing protects intellectual property while clinical development and regulatory review remain separate next steps.

What market opportunity does Clearmind reference for its MEAI-PEA therapy (CMND)?

Clearmind refers to a global MDD market projected to exceed $25 billion by 2030. According to Clearmind, the size underscores potential commercial opportunity if development and approvals succeed.

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