Clearmind Medici Stock Price, News & Analysis

Clearmind Medicine (Nasdaq: CMND) has launched its Electronic Data Capture (EDC) system for its Phase I/II clinical trial evaluating a MEAI-based treatment for Alcohol Use Disorder (AUD). The EDC system represents a important operational milestone, enabling:

• Real-time, secure data collection across study sites
• Automated edit checks and validation
• Secure randomization process
• Accurate tracking of safety events
• Informed consent procedures
• Proper patient allocation between study arms

The clinical trial aims to assess the safety, tolerability, and efficacy of Clearmind's psychedelic-derived, MEAI-based compound in individuals with alcohol addiction. The system includes separate notification flows for blinded and unblinded staff to maintain protocol compliance and trial integrity.

Clearmind Medicine (Nasdaq: CMND) has reached a significant milestone as its drug candidate CMND-100 arrives in the United States, preparing for its FDA-approved Phase I/IIa clinical trial for Alcohol Use Disorder (AUD) treatment.

The clinical trial will evaluate CMND-100, a proprietary MEAI-based oral drug candidate, for safety and efficacy in reducing alcohol consumption. The study will be conducted at prestigious institutions including Yale School of Medicine's Department of Psychiatry, Johns Hopkins University School of Medicine, and IMCA in Ramat Gan, Israel.

The company is targeting a significant market opportunity, as AUD affects over 28 million adults in the U.S., with an estimated global market potential of $35 billion. CMND-100 aims to reduce alcohol consumption and cravings through a novel mechanism of action.

Clearmind Medicine (Nasdaq: CMND) has signed a non-binding Letter of Intent with Polyrizon (Nasdaq: PLRZ) to develop a novel intranasal formulation for its psychedelic-based treatments. The collaboration aims to enhance the delivery of Clearmind's proprietary drug candidate, 5-Methoxy-2-aminoindane (MEAI), alone or combined with Palmitoylethanolamide (PEA).

The partnership focuses on developing an intranasal delivery system that could offer several advantages including:

• Faster absorption and onset of action
• Higher bioavailability for increased therapeutic effects
• Enhanced patient compliance through non-invasive administration

Under the agreement, Clearmind will fund the R&D process, while Polyrizon will advance formulation development using its proprietary intranasal drug delivery platform. Upon successful proof of concept, the parties plan to negotiate a definitive agreement covering IP rights, commercialization, and financial terms.

Clearmind Medicine (Nasdaq: CMND) has initiated its Phase I/IIa clinical trial for CMND-100, marking its transition to a clinical-stage pharmaceutical company. The trial will evaluate the safety, tolerability, and pharmacokinetics of CMND-100 in Alcohol Use Disorder (AUD) patients.

The study will be conducted at three prestigious institutions: IMCA in Israel, led by Prof. Mark Weiser, Yale School of Medicine's Department of Psychiatry, and Johns Hopkins University School of Medicine. The trial will also assess preliminary efficacy in reducing alcohol cravings and consumption.

CMND-100 is the company's proprietary MEAI-based oral drug candidate, designed to offer a novel approach by modulating reward mechanisms associated with addictive behavior. This represents a potential breakthrough in addressing the global AUD crisis, which affects approximately 400 million people worldwide and contributes to 2.6 million deaths annually according to WHO data.

Clearmind Medicine (NASDAQ: CMND) has secured a patent publication in South Korea for its innovative combination therapy using MEAI and N-Acylethanolamines to treat cocaine addiction. The patent is based on successful preclinical trials conducted at Bar-Ilan University's Gonda Multidisciplinary Brain Research Center in Israel.

The research demonstrated that animals treated with MEAI showed significant reduction in cocaine-induced cravings while maintaining normal responses to natural rewards like sucrose. This suggests MEAI specifically targets drug-related compulsions without affecting the general reward system.

The development is part of Clearmind's collaboration with SciSparc (NASDAQ: SPRC), combining Clearmind's MEAI psychedelic treatment with SciSparc's PEA for addiction and mental health applications. Multiple patent applications have been filed in the U.S. and other global jurisdictions.

Clearmind Medicine (Nasdaq: CMND) has announced the publication of a patent by Mexico's National Patent Office (IMPI) for its combination therapy treatment. The patent covers an innovative treatment combining MEAI and N-Acylethanolamines, targeting various binge behaviors including alcohol, eating, tobacco, shopping, and sexual conduct.

The patent emerged from Clearmind's collaboration with SciSparc (Nasdaq: SPRC), focusing on developing treatments for central nervous system disorders. The partnership aims to research combination therapies that integrate psychedelic compounds with N-Acylethanolamines family, including Palmitoylethanolamide (PEA).

Clearmind Medicine (Nasdaq: CMND), a clinical-stage biotech company developing psychedelic-derived therapeutics, announced the successful approval of all matters presented at its January 6, 2025 shareholders meeting. Key approvals include:

- Setting the board of directors at five members
- Election of directors for the upcoming year
- Appointment of Brightman Almagor Zohar & Co. (Deloitte Global Network) as company auditor
- Establishment of an omnibus equity incentive plan
- Authorization for potential share consolidation up to 50:1 ratio at board's discretion

Clearmind Medicine (Nasdaq: CMND) announced the publication of a European patent application for its combination therapy using MEAI and N-Acylethanolamines. The therapy targets various binge behaviors, including alcohol, eating, tobacco, shopping, and sexual conduct.

The patent stems from Clearmind's collaboration with SciSparc (Nasdaq: SPRC), focusing on combining psychedelic compounds with N-Acylethanolamines family, including Palmitoylethanolamide (PEA). The company has filed 13 patents across multiple jurisdictions related to this collaboration, strengthening its intellectual property portfolio in psychedelic therapies for binge behavior treatment.

Clearmind Medicine (NASDAQ: CMND) has received patent approval from the Macau International Intellectual Property Office for its MEAI-based binge behavior regulator program. The patent covers primary amine aminoindan compounds, including but not to 5-methoxy-2-aminoindan (MEAI), for regulating binge behavior.

This addition to Clearmind's intellectual property portfolio brings their total to 31 granted patents across 18 patent families, with coverage in major jurisdictions including the US, Europe, China, India, Hong Kong, and Macau. The company focuses on developing non-hallucinogenic proprietary molecules for treating substance addictions related to alcohol and food.