STOCK TITAN

CNS Pharmaceuticals' Chief Medical Officer, Sandra Silberman, MD, PhD to Present at the 2025 Brain Tumor Biotech Summit

Rhea-AI Impact
(Low)
Rhea-AI Sentiment
(Neutral)
Tags
conferences
CNS Pharmaceuticals announced that its Chief Medical Officer, Dr. Sandra Silberman, will present at the 2025 Brain Tumor Biotech Summit in New York. The presentation will focus on TPI 287, the company's drug candidate for glioblastoma treatment. TPI 287 is an abeotaxane that works similarly to other taxanes by stabilizing microtubules and inhibiting cell division. Unlike most taxanes, TPI 287 shows potential to cross the blood-brain barrier. In a Phase 1 trial combining TPI 287 with bevacizumab, the drug showed promising results with 3 Complete Responses and 9 Partial Responses among 23 evaluable patients. The FDA has granted TPI 287 Orphan Drug Designation for treating gliomas, pediatric neuroblastoma, and progressive supranuclear palsy.
CNS Pharmaceuticals ha annunciato che la sua Chief Medical Officer, la Dottoressa Sandra Silberman, presenterà al Brain Tumor Biotech Summit 2025 di New York. La presentazione sarà incentrata su TPI 287, il candidato farmaco dell'azienda per il trattamento del glioblastoma. TPI 287 è un abeotaxano che agisce in modo simile ad altri taxani stabilizzando i microtubuli e inibendo la divisione cellulare. A differenza della maggior parte dei taxani, TPI 287 sembra avere la capacità di attraversare la barriera ematoencefalica. In uno studio di Fase 1 che ha combinato TPI 287 con bevacizumab, il farmaco ha mostrato risultati promettenti con 3 risposte complete e 9 risposte parziali su 23 pazienti valutabili. La FDA ha concesso a TPI 287 la designazione di Farmaco Orfano per il trattamento di gliomi, neuroblastoma pediatrico e paralisi sopranucleare progressiva.
CNS Pharmaceuticals anunció que su Directora Médica, la Dra. Sandra Silberman, presentará en la Cumbre Biotecnológica de Tumores Cerebrales 2025 en Nueva York. La presentación se centrará en TPI 287, el candidato a fármaco de la compañía para el tratamiento del glioblastoma. TPI 287 es un abeotaxano que actúa de manera similar a otros taxanos al estabilizar los microtúbulos e inhibir la división celular. A diferencia de la mayoría de los taxanos, TPI 287 muestra potencial para cruzar la barrera hematoencefálica. En un ensayo de Fase 1 que combinó TPI 287 con bevacizumab, el medicamento mostró resultados prometedores con 3 respuestas completas y 9 respuestas parciales entre 23 pacientes evaluables. La FDA ha otorgado a TPI 287 la designación de Medicamento Huérfano para el tratamiento de gliomas, neuroblastoma pediátrico y parálisis supranuclear progresiva.
CNS Pharmaceuticals는 최고 의학 책임자인 Dr. Sandra Silberman이 2025년 뉴욕에서 열리는 뇌종양 바이오테크 서밋에서 발표할 것이라고 발표했습니다. 발표 내용은 회사의 교모세포종 치료 후보 약물인 TPI 287에 초점을 맞출 예정입니다. TPI 287은 미세소관을 안정화하고 세포 분열을 억제하는 다른 탁산 계열 약물과 유사하게 작용하는 아베오탁산입니다. 대부분의 탁산과 달리 TPI 287은 혈액뇌장벽을 통과할 가능성을 보입니다. TPI 287과 베바시주맙을 병용한 1상 시험에서 23명의 평가 가능한 환자 중 3명 완전 반응과 9명 부분 반응을 보여 유망한 결과를 나타냈습니다. FDA는 TPI 287에 교모세포종, 소아 신경아세포종, 진행성 핵상마비 치료를 위한 희귀의약품 지정을 승인했습니다.
CNS Pharmaceuticals a annoncé que sa Directrice Médicale, le Dr Sandra Silberman, présentera au Brain Tumor Biotech Summit 2025 à New York. La présentation portera sur le TPI 287, le candidat médicament de la société pour le traitement du glioblastome. Le TPI 287 est un abeotaxane qui agit de manière similaire aux autres taxanes en stabilisant les microtubules et en inhibant la division cellulaire. Contrairement à la plupart des taxanes, le TPI 287 montre un potentiel à traverser la barrière hémato-encéphalique. Lors d'un essai de phase 1 combinant le TPI 287 avec le bevacizumab, le médicament a montré des résultats prometteurs avec 3 réponses complètes et 9 réponses partielles parmi 23 patients évaluables. La FDA a accordé au TPI 287 la désignation de médicament orphelin pour le traitement des gliomes, du neuroblastome pédiatrique et de la paralysie supranucléaire progressive.
CNS Pharmaceuticals gab bekannt, dass ihre Chief Medical Officer, Dr. Sandra Silberman, auf dem Brain Tumor Biotech Summit 2025 in New York präsentieren wird. Die Präsentation wird sich auf TPI 287 konzentrieren, den Medikamentenkandidaten des Unternehmens zur Behandlung von Glioblastomen. TPI 287 ist ein Abeotaxan, das ähnlich wie andere Taxane wirkt, indem es Mikrotubuli stabilisiert und die Zellteilung hemmt. Im Gegensatz zu den meisten Taxanen zeigt TPI 287 das Potenzial, die Blut-Hirn-Schranke zu überwinden. In einer Phase-1-Studie, bei der TPI 287 mit Bevacizumab kombiniert wurde, zeigte das Medikament vielversprechende Ergebnisse mit 3 kompletten Remissionen und 9 partiellen Remissionen bei 23 auswertbaren Patienten. Die FDA hat TPI 287 den Orphan-Drug-Status für die Behandlung von Gliomen, pädiatrischem Neuroblastom und progressiver supranukleärer Lähmung verliehen.
Positive
  • None.
Negative
  • None.

In person presentation today, Thursday, June 5th at 9:30 AM ET to discuss Company's lead program, TPI 287, in development for treatment of glioblastoma multiforme (GBM)

HOUSTON, TX / ACCESS Newswire / June 5, 2025 / CNS Pharmaceuticals, Inc. (NASDAQ:CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and metastatic cancers in the brain and central nervous system, today announced that Sandra Silberman, M.D., Ph.D., Chief Medical Officer of CNS Pharmaceuticals, will present at the Lenox Hill Hospital, Department of Neurosurgery's Brain Tumor Biotech Summit being held on June 5, 2025 in New York, NY.

Details of the presentation are as follows:

Title: The Future and Promise of TPI 287- A Brain Penetrating Taxane with Documented Evidence of Efficacy Against Glioblastoma
Date and Time: Thursday, June 5, 2025 at 9:30 AM ET

As part of the presentation Dr. Silberman will discuss the Company's drug candidate, TPI 287. TPI 287 is an abeotaxane and has the same mechanism of action as other taxanes, e.g. paclitaxel (Taxol®) and docetaxel, in which it stabilizes microtubules and inhibits cell division, causing apoptosis and cell death. While most taxanes are substrates for multi-drug resistant transporters, which maintain the blood brain barrier (BBB), TPI 287's clinical data suggest it has the potential to cross the BBB and treat CNS tumors. In a Phase 1 trial treating glioblastoma patients with TPI 287 in combination with bevacizumab (Avastin®), the efficacy data included 3 Complete Responses and 9 Partial Responses out of 23 evaluable patients.

TPI 287 has been granted Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for the treatment of gliomas, pediatric neuroblastoma, and progressive supranuclear palsy.

The 2025 Brain Tumor Biotech Summit brings together innovators in neuroscience and oncology with investors in the field of biotechnology and healthcare life science. The Conference's goal is to foster and encourage collaboration among our neuroscience colleagues and the biotechnology community to accelerate the development of new, life-saving therapies for patients with brain tumors and other Central Nervous System diseases.

For more information about the 2025 Brain Tumor Biotech Summit, please visit the event website.

About CNS Pharmaceuticals, Inc.

CNS Pharmaceuticals is a clinical-stage pharmaceutical company developing a pipeline of anti-cancer drug candidates for the treatment of primary and metastatic cancers of the brain and central nervous system.

The Company's drug candidate TPI 287 is an abeotaxane, which stabilizes microtubules and inhibits cell division, causing apoptosis and cell death. The initial clinical efficacy data suggest TPI 287 has the potential to cross the blood-brain barrier and treat CNS tumors. TPI 287 also has been tested in over 350 patients in clinical trials as a monotherapy and in combination with bevacizumab for the treatment of a range of diseases or conditions, including recurrent glioblastoma, recurrent neuroblastoma and medulloblastoma, advanced malignancies, progressive neoplastic disease, advanced unresectable pancreatic cancer, metastatic melanoma, and breast cancer metastatic to the brain. To date TPI 287 appears have both an excellent safety profile and high tolerability among patients.

For more information, please visit www.CNSPharma.com, and connect with the Company on X, Facebook, and LinkedIn.

Forward-Looking Statements

Some of the statements in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. . These statements relate to future events, future expectations, plans and prospects. Although CNS believes the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been materially different from the results expressed or implied by such forward-looking statements. CNS has attempted to identify forward-looking statements by terminology including ''believes,'' ''estimates,'' ''anticipates,'' ''expects,'' ''plans,'' ''projects,'' ''intends,'' ''potential,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' ''approximately'' or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including market and other conditions and those discussed under Item 1A. "Risk Factors" in CNS's most recently filed Form 10-K filed with the Securities and Exchange Commission ("SEC") and updated from time to time in its Form 10-Q filings and in its other public filings with the SEC. Any forward-looking statements contained in this press release speak only as of its date. CNS undertakes no obligation to update any forward-looking statements contained in this press release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated events, except as required by law.

CONTACT:

JTC Team, LLC
Jenene Thomas
908.824.0775
CNSP@jtcir.com

SOURCE: CNS Pharmaceuticals, Inc.



View the original press release on ACCESS Newswire

FAQ

What is CNS Pharmaceuticals (CNSP) presenting at the 2025 Brain Tumor Biotech Summit?

CNS Pharmaceuticals is presenting on TPI 287, their brain-penetrating taxane drug candidate for glioblastoma treatment, which has shown documented evidence of efficacy in clinical trials.

What are the key clinical results for CNSP's TPI 287 in glioblastoma treatment?

In a Phase 1 trial combining TPI 287 with bevacizumab, the drug showed promising results with 3 Complete Responses and 9 Partial Responses out of 23 evaluable patients.

What FDA designations has CNS Pharmaceuticals' TPI 287 received?

TPI 287 has received Orphan Drug Designation from the FDA for treating gliomas, pediatric neuroblastoma, and progressive supranuclear palsy.

How does CNS Pharmaceuticals' TPI 287 differ from other taxanes?

Unlike most taxanes which cannot pass the blood-brain barrier due to multi-drug resistant transporters, TPI 287's clinical data suggests it has the potential to cross the blood-brain barrier and treat CNS tumors.
CNS Pharmaceuticals

NASDAQ:CNSP

CNSP Rankings

CNSP Latest News

CNSP Stock Data

5.74M
5.45M
0.44%
2.58%
17.91%
Biotechnology
Pharmaceutical Preparations
Link
United States
HOUSTON