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Centessa Pharmaceuticals plc - CNTA STOCK NEWS

Welcome to our dedicated page for Centessa Pharmaceuticals plc news (Ticker: CNTA), a resource for investors and traders seeking the latest updates and insights on Centessa Pharmaceuticals plc stock.

Centessa Pharmaceuticals plc (NASDAQ: CNTA) is a next-generation biopharmaceutical company based in Cambridge, Massachusetts, dedicated to transforming the traditional drug development model. By leveraging an asset-centric R&D approach at scale, Centessa is advancing a robust pipeline of highly validated programs led by industry-leading teams. Each program is managed by a Centessa subsidiary and supported by a centralized infrastructure and executive management team.

The company’s clinical-stage assets include:

  • SerpinPC - A novel treatment for Hemophilia A and B, currently in Phase 2b trials. SerpinPC is a subcutaneously administered inhibitor of APC, aiming to provide effective treatment irrespective of severity or inhibitor status.
  • LB101 - A cutting-edge PD-L1xCD47 LockBody, targeting solid tumors. LB101 is currently in a Phase 1/2a clinical trial, designed to selectively drive potent effector functions to the tumor micro-environment while minimizing systemic toxicity.
  • ORX750 - An orally administered, highly selective orexin receptor 2 (OX2R) agonist for Narcolepsy Type 1 (NT1) and other sleep disorders, currently in its Phase 1 clinical study.
  • MGX292 - Targeting Pulmonary Arterial Hypertension (PAH).
  • Undisclosed programs targeting solid tumors.

Recent Achievements include:

  • Phase 2b study PRESent-3 of SerpinPC showing promising preliminary results.
  • FDA Fast Track designation for SerpinPC in treating Hemophilia B.
  • Progress in LB101's Phase 1/2a clinical trial.
  • Launch of the Phase 1 study for ORX750, with initial proof-of-concept data in sleep-deprived healthy volunteers expected later this year.

Centessa’s innovative approach and comprehensive pipeline aim to deliver transformational medicines to patients, setting a new standard of care. For more information, visit their official website at http://www.centessa.com/.

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Centessa Pharmaceuticals (Nasdaq: CNTA) has bolstered its executive team with the appointment of John Crowley CPA as Chief Financial Officer (CFO) and Gregory Weinhoff MD MBA as Chief Business Officer (CBO), effective June 10, 2024. Crowley, with over 20 years of experience in life sciences finance, previously served as CFO of Fusion Pharmaceuticals and Merus. Weinhoff, formerly Centessa's CFO, has over two decades of business development expertise and co-founded Arvelle Therapeutics. He has led significant financial and strategic initiatives in the pharmaceutical sector. These appointments aim to strengthen Centessa's financial strategy and business development as it advances its core clinical programs.

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Centessa Pharmaceuticals (Nasdaq: CNTA) announced its participation in upcoming investor conferences. Members of its management team will present at the Jefferies Global Healthcare Conference on June 6, 2024, in New York, NY, and at the Goldman Sachs 45th Annual Global Healthcare Conference on June 11, 2024, in Miami, FL. Participants can access live webcasts and archived recordings of these events through the company's investor relations website.

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Centessa Pharmaceuticals (Nasdaq: CNTA) reported its Q1 2024 financial results and business highlights. Key updates include the initiation of a Phase 1 clinical trial for ORX750, an orexin receptor 2 agonist for narcolepsy, and ongoing registrational studies for SerpinPC in hemophilia B. The company completed a public offering, raising $107.2 million, extending its cash runway to mid-2026. Financially, Centessa reported a net loss of $38 million for Q1 2024, down from $50.7 million in Q1 2023. R&D and administrative expenses also saw reductions, with R&D at $22.7 million and G&A at $13.4 million.

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Centessa Pharmaceuticals plc (Nasdaq: CNTA) announced the pricing of a $100 million public offering of 10,810,810 American Depositary Shares at $9.25 per ADS. The company expects to receive approximately $100 million in gross proceeds from this offering.
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Centessa Pharmaceuticals plc (Nasdaq: CNTA) has announced a proposed public offering of $100 million of American Depositary Shares (ADSs), with the intention to grant underwriters an option to purchase additional shares. The offering is subject to market conditions and led by Goldman Sachs and Leerink Partners. The ADSs are offered under a registration statement on Form S-3 filed with the SEC.
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Centessa Pharmaceuticals plc (Nasdaq: CNTA) has received FDA clearance for the Investigational New Drug application to start a Phase 1 clinical trial of ORX750 for narcolepsy treatment. ORX750, an orexin receptor 2 agonist, targets orexin neuron loss in narcolepsy types 1 and 2, idiopathic hypersomnia, and other sleep-wake disorders. The study will assess safety, tolerability, and pharmacokinetics of ORX750 in healthy adults, with proof-of-concept data expected in the second half of 2024.
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Centessa Pharmaceuticals plc (CNTA) reports recent business highlights and financial results for the fourth quarter and full-year ended December 31, 2023. The company is focused on the registrational studies of SerpinPC for hemophilia B, advancing its orexin agonist program, and evaluating its LockBody technology platform. Recent data shows promising results for SerpinPC, with a 96% reduction in bleeding rates, and no thrombosis observed. The company plans to share clinical proof-of-concept data for ORX750 in 2024. Financially, Centessa has $256.5 million in cash, research & development expenses of $29.7 million, general & administrative expenses of $12.3 million, and a net loss of $36.8 million for the fourth quarter of 2023.
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Centessa Pharmaceuticals plc (CNTA) to participate in TD Cowen's 44th Annual Health Care Conference in Boston, MA. A fireside chat scheduled for March 5th. Live audio webcast and archived recording available on the company's website.
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Centessa Pharmaceuticals plc (Nasdaq: CNTA) announces the presentation of additional 52-week data from the ongoing Phase 2a study of SerpinPC for hemophilia treatment at EAHAD Congress. SerpinPC shows promise as a novel inhibitor of activated protein C, with positive results reinforcing its potential as a convenient subcutaneous treatment option.
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Centessa Pharmaceuticals plc (Nasdaq: CNTA) announced its participation in upcoming investor conferences, including Guggenheim’s 6th Annual Biotechnology Conference and Leerink Partners Global Biopharma Conference 2024. The live webcasts and archived recordings will be available on the company's investor relations section.
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FAQ

What does Centessa Pharmaceuticals specialize in?

Centessa Pharmaceuticals specializes in developing transformational medicines through an asset-centric R&D model, focusing on treatments for hemophilia, solid tumors, and sleep-wake disorders.

Where is Centessa Pharmaceuticals headquartered?

Centessa Pharmaceuticals is headquartered in Cambridge, Massachusetts.

What is SerpinPC?

SerpinPC is a subcutaneously administered inhibitor of APC in clinical trials for treating Hemophilia A and B, aiming to provide effective treatment regardless of severity or inhibitor status.

What stage is LB101 in?

LB101, a PD-L1xCD47 LockBody targeting solid tumors, is currently in a Phase 1/2a clinical trial.

What is the focus of ORX750?

ORX750 is an orally administered, highly potent orexin receptor 2 (OX2R) agonist aimed at treating Narcolepsy Type 1 (NT1) and other sleep-wake disorders, currently in Phase 1 clinical study.

Has SerpinPC received any special designations?

Yes, SerpinPC has received Fast Track designation from the FDA for treating Hemophilia B.

What kind of development model does Centessa Pharmaceuticals use?

Centessa Pharmaceuticals utilizes an asset-centric R&D model, where each program is managed by a subsidiary and supported by centralized infrastructure and management.

What other programs are in Centessa's pipeline?

In addition to SerpinPC, LB101, and ORX750, Centessa is developing MGX292 for Pulmonary Arterial Hypertension and has undisclosed programs targeting solid tumors.

What recent achievements has Centessa Pharmaceuticals made?

Recent achievements include promising preliminary results from the Phase 2b study of SerpinPC, FDA Fast Track designation for SerpinPC, progress in LB101's Phase 1/2a trial, and the initiation of the Phase 1 study for ORX750 with expected proof-of-concept data later this year.

How can I find more information about Centessa Pharmaceuticals?

For more detailed information, you can visit Centessa Pharmaceuticals' official website at http://www.centessa.com/.

Centessa Pharmaceuticals plc

Nasdaq:CNTA

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1.21B
113.04M
2.05%
77.36%
0.94%
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