Cocrystal Pharma Provides an Update on the Clinical Development of its Novel, Broad-Spectrum Antiviral Investigational Candidates

Rhea-AI Summary

Cocrystal Pharma, Inc. (Nasdaq: COCP) provides an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and its oral PB2 inhibitor CC-42344 for the treatment of pandemic and seasonal influenza A. The preliminary data of the ongoing Phase 2a and Phase 1 studies showed CC-42344 and CD-988 were well-tolerated with favorable safety profiles. CDI-988 targets a highly conserved region in the active site of the main 3CL protease required for viral RNA replication for pandemic norovirus and coronaviruses, including SARS-CoV-2. CC-42344 binds to a highly conserved PB2 site of the influenza A polymerase complex and exhibits a novel mechanism of action that inhibits viral replication. Cocrystal expects to report topline results from the Phase 1 and Phase 2a studies this year.

Medical Research Analyst

The recent update from Cocrystal Pharma regarding their clinical development of CDI-988 and CC-42344 is significant for the pharmaceutical industry and potential investors. The focus on pan-norovirus and pan-coronavirus, as well as pandemic and seasonal influenza A, targets highly contagious diseases that have global impact. The use of structure-based drug discovery technology indicates a methodological approach in their R&D process that may increase the likelihood of successful drug development. The favorable preliminary safety data from ongoing trials enhances the credibility of these drug candidates and could lead to increased investor confidence.

From a medical research perspective, the targeting of a highly conserved region in the active site of the main 3CL protease by CDI-988 is noteworthy, as this approach may offer broad-spectrum antiviral activity. Similarly, CC-42344's novel mechanism of action, by binding to a conserved PB2 site, could represent a significant advancement in treating influenza A. Both drugs' progress into later stages of clinical trials will be crucial in determining their efficacy and potential market penetration.

Financial Analyst

For investors, the development of CDI-988 and CC-42344 by Cocrystal Pharma represents a potential opportunity for growth, especially given the global demand for treatments against pandemic viruses. The progression to Phase 2a for CC-42344 and the expected release of topline results from Phase 1 studies for both drug candidates could act as key catalysts for the company's stock price. However, it is important to consider the inherent risks associated with pharmaceutical R&D, including the possibility of unfavorable future trial results or regulatory hurdles.

Considering the market opportunities for oral treatments for viruses like norovirus and SARS-CoV-2, the success of these drugs could lead to significant revenue streams for Cocrystal. It is essential for investors to monitor the upcoming topline results, as they will provide critical data that could influence the company's valuation and future investment decisions.

Epidemiologist

The development of broad-spectrum antiviral drugs such as CDI-988 and CC-42344 is of great importance from an epidemiological standpoint. The ability to target multiple strains of viruses, particularly those causing pandemics, can lead to improved public health outcomes and reduce the burden on healthcare systems. The mention of well-tolerated drugs with favorable safety profiles is encouraging, as it suggests potential for widespread use upon approval. The impact of these drugs on controlling the spread of infectious diseases could be substantial, especially if they prove to be effective in preventing or reducing the severity of illness.

Furthermore, the oral administration of these treatments is a significant advantage, as it facilitates easier distribution and compliance compared to intravenous or injectable medications. This could enhance the drugs' impact on disease control, especially in areas with limited healthcare infrastructure.

BOTHELL, Wash., Jan. 04, 2024 (GLOBE NEWSWIRE) -- Cocrystal Pharma, Inc. (Nasdaq: COCP) (“Cocrystal” or the “Company”) provides an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and its oral PB2 inhibitor CC-42344 for the treatment of pandemic and seasonal influenza A. CDI-988 and CC-42344 were specifically designed and developed using Cocrystal’s unique structure-based drug discovery technology platform to be effective on a broad range of viruses causing these diseases.

“We are encouraged that the preliminary data of the ongoing Phase 2a and Phase 1 studies showed CC-42344 and CD-988 were well-tolerated with favorable safety profiles,” said Sam Lee, Ph.D., Cocrystal’s President and co-CEO. “We see great promise with both of these drug candidates as potential effective oral treatments for highly contagious, pandemic viruses, while also providing significant market opportunities for Cocrystal.”

CDI-988 targets a highly conserved region in the active site of the main 3CL protease required for viral RNA replication for pandemic norovirus and coronaviruses, including SARS-CoV-2. CDI-988 is being evaluated for safety and pharmacokinetics in a randomized, double-blinded, placebo-controlled Phase 1 study in healthy subjects being conducted in Australia. The Company reports favorable preliminary data from the single-ascending dose cohorts of the clinical study. Cocrystal expects to report topline results from the Phase 1 study this year.

CC-42344 binds to a highly conserved PB2 site of the influenza A polymerase complex and exhibits a novel mechanism of action that inhibits viral replication. A randomized, double-blind, placebo-controlled Phase 2a clinical study with CC-42344 is underway in the United Kingdom. The Company reports favorable tolerability and safety in the first cohort of the Phase 2a influenza A challenge study and expects to report topline results from the Phase 2a clinical study this year. In 2022 Cocrystal reported favorable safety and tolerability results in the healthy volunteer Phase 1 study with CC-42344 conducted in Australia.

About Norovirus

Although norovirus is a worldwide public health problem, there are no effective treatments or vaccines. Norovirus afflicts an estimated 685 million people annually at an estimated societal cost of $60 billion. About 200 million cases are seen among children under 5 years old, leading to an estimated 50,000 child deaths every year, mostly in developing countries, according to the Centers for Disease Control and Prevention (CDC). CDI-988 in vitro studies showed potent broad-spectrum antiviral activity against a panel of pandemic GII.4 norovirus proteases, which have caused the majority of norovirus outbreaks worldwide since 2002, and a favorable pharmacokinetic property targeting the gastrointestinal tract.

About COVID-19
COVID-19 hospitalizations have recently increased in the U.S. with the new JN.1 variant responsible for about 20% of these cases. Driven by the anticipated emergence of new COVID-19 variants, the global COVID-19 therapeutics market is estimated to exceed $16 billion by the end of 2031. The ability of someone with no symptoms to transmit infection to another person has heightened the public health challenge of COVID-19. CDI-988 exhibited superior in vitro potency against SARS-CoV-2 with activity maintained against variants of concern. By targeting the viral replication protease, Cocrystal believes it is possible to develop an effective treatment for all coronaviruses, including COVID-19 and its variants, as well as for Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS).

About Seasonal Influenza
Each year there are approximately 1 billion cases of seasonal influenza worldwide, with 3-5 million severe illnesses and up to 650,000 deaths, according to the World Health Organization. On average about 8% of the U.S. population contracts influenza each season. In addition to the health risk, influenza is responsible for approximately $10.4 billion in direct costs for hospitalizations and outpatient visits for adults in the U.S. annually.

About Cocrystal Pharma, Inc.
Cocrystal Pharma, Inc. is a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication process of influenza viruses, coronaviruses (including SARS-CoV-2) noroviruses and hepatitis C viruses. Cocrystal employs unique structure-based technologies and Nobel Prize-winning expertise to create first- and best-in-class antiviral drugs. For further information about Cocrystal, please visit www.cocrystalpharma.com.

Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the promise and potential of the two product candidates, the clinical development of CC-42344 as a product candidate for oral antiviral inhibitor for the treatment of pandemic and seasonal influenza A and the Phase 2a study for such product candidate, CC-988 as a product candidate for dual oral antiviral inhibitor for the treatment of coronavirus and norovirus and the Phase 1 study for such product candidate, the potential efficacy and clinical benefits of, and market for, such product candidates, and the expected results and topline data from these clinical trials in 2024. The words "believe," "may," "estimate," "continue," "anticipate," "intend," "should," "plan," "could," "target," "potential," "is likely," "will," "expect" and similar expressions, as they relate to us, are intended to identify forward-looking statements. We have based these forward-looking statements largely on our current expectations and projections about future events. Some or all of the events anticipated by these forward-looking statements may not occur. Important factors that could cause actual results to differ from those in the forward-looking statements include, but are not limited to, risks relating to our ability to proceed with the studies including recruiting volunteers and procuring materials for such studies by our clinical research organizations and vendors, and the results of such studies. Further information on our risk factors is contained in our filings with the SEC, including our Annual Report on Form 10-K for the year ended December 31, 2022. Any forward-looking statement made by us herein speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by law.

Investor Contact:
LHA Investor Relations
Jody Cain
310-691-7100
jcain@lhai.com

Media Contact:
JQA Partners
Jules Abraham
917-885-7378
Jabraham@jqapartners.com

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What is the update provided by Cocrystal Pharma, Inc. (Nasdaq: COCP)?

Cocrystal Pharma, Inc. (Nasdaq: COCP) provides an update on the clinical development of its oral first-in-class pan-norovirus and pan-coronavirus dual protease inhibitor CDI-988 and its oral PB2 inhibitor CC-42344 for the treatment of pandemic and seasonal influenza A.

What are the drug candidates being developed by Cocrystal Pharma, Inc. (Nasdaq: COCP)?

The drug candidates being developed by Cocrystal Pharma, Inc. (Nasdaq: COCP) are CDI-988 and CC-42344, targeting pandemic and seasonal influenza A, as well as norovirus and coronaviruses.

What are the key features of CDI-988 and CC-42344?

CDI-988 targets a highly conserved region in the active site of the main 3CL protease required for viral RNA replication for pandemic norovirus and coronaviruses, including SARS-CoV-2. CC-42344 binds to a highly conserved PB2 site of the influenza A polymerase complex and exhibits a novel mechanism of action that inhibits viral replication.

What are the preliminary results of the ongoing Phase 2a and Phase 1 studies for CC-42344 and CD-988?

The preliminary data of the ongoing Phase 2a and Phase 1 studies showed CC-42344 and CD-988 were well-tolerated with favorable safety profiles.

Where are the clinical studies for CDI-988 and CC-42344 being conducted?

The clinical studies for CDI-988 and CC-42344 are being conducted in Australia and the United Kingdom.

What can be expected from Cocrystal Pharma, Inc. (Nasdaq: COCP) in the near future?

Cocrystal Pharma, Inc. (Nasdaq: COCP) expects to report topline results from the Phase 1 and Phase 2a studies for CDI-988 and CC-42344 this year.