Caribou Biosciences Reports Second Quarter 2025 Financial Results and Provides Business Update
Rhea-AI Summary
Caribou Biosciences (Nasdaq: CRBU) reported Q2 2025 financial results and provided updates on its clinical programs. The company ended Q2 with $183.9 million in cash, expected to fund operations into H2 2027. Key financial metrics include $2.7 million in licensing revenue and a GAAP net loss of $54.1 million ($0.58 per share).
Clinical highlights include completion of enrollment for both the CB-010 ANTLER Phase 1 trial in large B cell lymphoma and the dose escalation portion of the CB-011 CaMMouflage Phase 1 trial in multiple myeloma. The company plans to present robust datasets from both programs in H2 2025, with CB-010 showing potential outcomes comparable to approved autologous CAR-T cell therapies.
The company reported non-recurring, non-cash impairment charges of $21.3 million related to strategic pipeline prioritization and investment impairment.Positive
- Cash runway extended into H2 2027 with $183.9M in cash and equivalents
- CB-010 showing potential outcomes comparable to approved autologous CAR-T therapies
- Completed enrollment in both CB-010 and CB-011 clinical trials
- R&D expenses decreased by 22% YoY to $27.7M due to strategic prioritization
Negative
- Net loss increased to $54.1M from $37.7M YoY
- Licensing revenue declined to $2.7M from $3.5M YoY
- $21.3M in non-recurring impairment charges from pipeline prioritization
- Workforce reduction implemented as part of strategic prioritization
News Market Reaction
On the day this news was published, CRBU gained 8.94%, reflecting a notable positive market reaction. Argus tracked a trough of -3.6% from its starting point during tracking. Our momentum scanner triggered 7 alerts that day, indicating moderate trading interest and price volatility. This price movement added approximately $13M to the company's valuation, bringing the market cap to $156M at that time.
Data tracked by StockTitan Argus on the day of publication.
-- Two robust clinical datasets from CB-010 and CB-011 expected to be disclosed in H2 2025 --
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BERKELEY, Calif., Aug. 12, 2025 (GLOBE NEWSWIRE) -- Caribou Biosciences, Inc. (Nasdaq: CRBU), a leading clinical-stage CRISPR genome-editing biopharmaceutical company, today reported financial results for the second quarter 2025 and provided a business update for its oncology clinical programs CB-010 and CB-011 with data disclosures on track for H2 2025.
“Caribou is advancing allogeneic CAR-T cell programs to deliver off-the-shelf therapies designed for rapid treatment and broad patient access,” said Rachel Haurwitz, PhD, Caribou’s president and CEO. “Our clinical programs, CB-010 for large B cell lymphoma and CB-011 for multiple myeloma, continue to generate encouraging Phase 1 results, reinforcing our conviction in the potential of these therapies. We remain on track to report robust datasets from both programs this year, which we expect to provide meaningful insights into the potential of our approach and the future of allogeneic CAR-T cell therapies.”
Clinical highlights
CB-010, a clinical-stage allogeneic anti-CD19 CAR-T cell therapy for B cell non-Hodgkin lymphoma
- Caribou completed enrollment of the 20-patient confirmatory cohort using the Company’s partial HLA matching strategy in the ANTLER Phase 1 clinical trial for patients with second-line large B cell lymphoma (2L LBCL).
- To date, data continue to demonstrate that a single dose of CB-010 has the potential to drive outcomes that are on par with the safety, efficacy, and durability of approved autologous CAR-T cell therapies.
CB-011, a clinical-stage allogeneic anti-BCMA CAR-T cell therapy for multiple myeloma
- Caribou completed planned enrollment for the dose escalation portion of the CaMMouflage Phase 1 clinical trial for patients with relapsed or refractory multiple myeloma (r/r MM).
- Caribou continues to observe encouraging efficacy in patients treated with CB-011 at multiple active dose levels.
2025 anticipated milestones
- CB-010 ANTLER: Caribou plans to present data from both the additional 2L and prior CD19 relapsed LBCL patient cohorts in H2 2025 and is interacting with the FDA on a potential pivotal trial to be initiated following alignment. This update is expected to include:
- Initial safety and efficacy data on the confirmatory cohort (20 patients) with partial HLA matching, with a minimum of six months of follow up for the majority of patients, as well as an update on the larger, maturing dataset presented previously.
- Pivotal trial design and timeline, contingent on positive data and FDA alignment.
- CB-011 CaMMouflage: Caribou plans to present dose escalation data from its ongoing CaMMouflage Phase 1 clinical trial in r/r MM in H2 2025. This update is expected to include:
- Initial safety and efficacy data on a minimum of 25 patients at multiple dose levels using the deeper lymphodepletion regimen with at least three months of follow up.
- Recommended dose(s) for expansion and plans for dose expansion.
Second quarter 2025 financial results
Cash, cash equivalents, and marketable securities: Caribou had
Licensing and collaboration revenue: Revenue from Caribou’s licensing and collaboration agreements was
R&D expenses: Research and development expenses were
G&A expenses: General and administrative expenses were
Non-recurring, non-cash impairment charges: Non-recurring, non-cash impairment charges were
GAAP and non-GAAP net loss and net loss per share, basic and diluted: Caribou reported a net loss of
Note regarding use of non-GAAP financial measures
In this press release, Caribou has presented certain financial information that has not been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”). These non-GAAP financial measures are non-GAAP net loss and non-GAAP net loss per share, which are defined as net loss and net loss per share, respectively, excluding non-cash impairment charges. Caribou believes that these non-GAAP financial measures, when considered together with the GAAP figures, can enhance an overall understanding of Caribou’s operational performance from period-to-period by excluding items that are not indicative of Caribou's core business operations. The non-GAAP financial measures are included with the intent of providing investors with a more complete understanding of Caribou’s operating results and underlying business trends. In addition, these non-GAAP financial measures are among the indicators Caribou’s management uses for planning purposes and to measure Caribou’s performance. These non-GAAP financial measures should be considered in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The non-GAAP financial measures used by Caribou may be calculated differently from, and therefore may not be comparable to, non-GAAP financial measures used by other companies. Please refer to the below reconciliation of these non-GAAP financial measures to the comparable GAAP financial measures.
About CB-010
CB-010 is an allogeneic anti-CD19 CAR-T cell therapy being evaluated in patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL) in the ongoing ANTLER Phase 1 clinical trial. To Caribou’s knowledge, CB-010 is the first allogeneic CAR-T cell therapy in the clinic with a PD-1 knockout, a genome-editing strategy designed to enhance CAR-T cell activity by limiting premature CAR-T cell exhaustion. The FDA granted CB-010 Regenerative Medicine Advanced Therapy (RMAT), Orphan Drug, and Fast Track designations for B-NHL. Additional information on the ANTLER trial (NCT04637763) can be found at clinicaltrials.gov .
About CB-011
CB-011 is an allogeneic anti-BCMA CAR-T cell therapy being evaluated in patients with relapsed or refractory multiple myeloma (r/r MM) in the CaMMouflage Phase 1 trial. To Caribou’s knowledge, CB-011 is the first allogeneic CAR-T cell therapy in the clinic that is engineered to enable activity through an immune cloaking strategy with a B2M knockout and insertion of a B2M–HLA-E fusion protein to blunt immune-mediated rejection. CB-011 has been granted Fast Track and Orphan Drug designations by the FDA. Additional information on the CaMMouflage trial (NCT05722418) can be found at clinicaltrials.gov.
About Caribou Biosciences, Inc.
Caribou Biosciences is a clinical-stage CRISPR genome-editing biopharmaceutical company dedicated to developing transformative therapies for patients with devastating diseases. The Company’s genome-editing platform, including its Cas12a chRDNA technology, enables superior precision to develop cell therapies that are armored to potentially improve activity against diseases. Caribou is focused on CB-010 and CB-011 as off-the-shelf CAR-T cell therapies that have the potential to provide broad access and rapid treatment for patients with hematologic malignancies. Follow the Company @CaribouBio and visit www.cariboubio.com.
Forward-looking statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential,” or “continue,” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. These forward-looking statements include, without limitation, statements related to Caribou’s strategy, plans, and objectives, and expectations regarding its clinical programs, including its expectations relating to (i) the timing of reporting ANTLER Phase 1 clinical trial data in H2 2025 from both the additional 2L and prior CD19 relapsed LBCL patient cohorts and the timing of an ANTLER pivotal clinical trial, including reaching alignment with the FDA on a pivotal trial design; (ii) the timing of reporting dose escalation data in H2 2025 from the ongoing CaMMouflage Phase 1 clinical trial for CB-011 in r/r MM; and (iii) its expected funding runway of cash, cash equivalents, and marketable securities. Management believes that these forward-looking statements are reasonable as and when made. However, such forward-looking statements are subject to risks and uncertainties, and actual results may differ materially from any future results expressed or implied by the forward-looking statements. Risks and uncertainties include, without limitation, risks inherent in the development of allogeneic CAR-T cell therapy products; uncertainties related to the initiation, cost, timing, progress, and results of its current and future research and development programs and clinical trials; the risk that initial, preliminary, or interim clinical trial data will not ultimately be predictive of the safety and efficacy of Caribou’s product candidates or that clinical outcomes may differ as patient enrollment continues and as more patient data becomes available; the risk that preclinical study results observed will not be borne out in human patients or different conclusions or considerations are reached once additional data have been received and fully evaluated; the ability to obtain key regulatory input and approvals; and risks related to its limited operating history, history of net operating losses, financial position, and its ability to raise additional capital as needed to fund its operations and product candidate development, as well as other risk factors described from time to time in Caribou’s filings with the Securities and Exchange Commission (SEC), including its Annual Report on Form 10-K for the year ended December 31, 2024, and subsequent SEC filings. In light of the significant uncertainties in these forward-looking statements, you should not rely upon forward-looking statements as predictions of future events. Except as required by law, Caribou undertakes no obligation to update publicly any forward-looking statements for any reason.
| Caribou Biosciences, Inc. Condensed Consolidated Balance Sheet Data (in thousands) (unaudited) | |||||
| June 30, 2025 | December 31, 2024 | ||||
| Cash, cash equivalents, and marketable securities | $ | 183,948 | $ | 249,386 | |
| Total assets | 220,903 | 313,313 | |||
| Total liabilities | 54,771 | 60,362 | |||
| Total stockholders’ equity | 166,132 | 252,951 | |||
| Total liabilities and stockholders' equity | $ | 220,903 | $ | 313,313 | |
| Caribou Biosciences, Inc. Condensed Consolidated Statement of Operations (in thousands, except share and per share data) (unaudited) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Licensing and collaboration revenue | $ | 2,667 | $ | 3,464 | $ | 5,020 | $ | 5,893 | |||||||
| Operating expenses: | |||||||||||||||
| Research and development | 27,692 | 35,480 | 63,223 | 69,268 | |||||||||||
| General and administrative | 10,403 | 11,485 | 20,138 | 26,128 | |||||||||||
| Impairment charges | 12,150 | — | 12,150 | — | |||||||||||
| Total operating expenses | 50,245 | 46,965 | 95,511 | 95,396 | |||||||||||
| Loss from operations | (47,578 | ) | (43,501 | ) | (90,491 | ) | (89,503 | ) | |||||||
| Other income (expense): | |||||||||||||||
| Impairment of equity investment | (9,158 | ) | — | (9,158 | ) | — | |||||||||
| Change in fair value of the MSKCC success payments liability | 451 | 1,795 | 785 | 2,098 | |||||||||||
| Other income, net | 2,187 | 4,009 | 4,775 | 8,474 | |||||||||||
| Total other income (expense) | (6,520 | ) | 5,804 | (3,598 | ) | 10,572 | |||||||||
| Net loss | (54,098 | ) | (37,697 | ) | (94,089 | ) | (78,931 | ) | |||||||
| Other comprehensive loss | |||||||||||||||
| Net unrealized (loss) gain on available-for-sale marketable securities, net of tax | (127 | ) | 3 | (215 | ) | (349 | ) | ||||||||
| Net comprehensive loss | $ | (54,225 | ) | $ | (37,694 | ) | $ | (94,304 | ) | $ | (79,280 | ) | |||
| Net loss per share, basic and diluted | $ | (0.58 | ) | $ | (0.42 | ) | $ | (1.01 | ) | $ | (0.88 | ) | |||
| Weighted-average common shares outstanding, basic and diluted | 93,028,698 | 90,340,932 | 92,855,060 | 89,821,935 | |||||||||||
| MSKCC: Memorial Sloan Kettering Cancer Center | |||||||||||||||
| Caribou Biosciences, Inc. Reconciliation of GAAP to Non-GAAP Net Loss and Net Loss per Share (in thousands, except share and per share data) (unaudited) | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30, | ||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||
| Net loss | $ | (54,098 | ) | $ | (37,697 | ) | $ | (94,089 | ) | $ | (78,931 | ) | |||
| Adjustments: | |||||||||||||||
| Non-cash impairment charges | 21,308 | — | 21,308 | — | |||||||||||
| Non-GAAP net loss | $ | (32,790 | ) | $ | (37,697 | ) | $ | (72,781 | ) | $ | (78,931 | ) | |||
| Net loss per share, basic and diluted | $ | (0.58 | ) | $ | (0.42 | ) | $ | (1.01 | ) | $ | (0.88 | ) | |||
| Adjustments: | |||||||||||||||
| Non-cash impairment charges per share | 0.23 | — | 0.23 | — | |||||||||||
| Non-GAAP net loss per share, basic and diluted* | $ | (0.35 | ) | $ | (0.42 | ) | $ | (0.78 | ) | $ | (0.88 | ) | |||
| Weighted-average common shares outstanding, basic and diluted | 93,028,698 | 90,340,932 | 92,855,060 | 89,821,935 | |||||||||||
| *Non-GAAP net loss per share, basic and diluted may not total due to rounding | |||||||||||||||
Caribou Biosciences, Inc. contact:
Peggy Vorwald, PhD
investor.relations@cariboubio.com
media@cariboubio.com
FAQ
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