Welcome to our dedicated page for Caribou Biosciences news (Ticker: CRBU), a resource for investors and traders seeking the latest updates and insights on Caribou Biosciences stock.
Caribou Biosciences develops CRISPR genome-edited, allogeneic CAR-T cell therapies for hematologic malignancies. Company updates center on vispacabtagene regedleucel, or vispa-cel, an anti-CD19 CAR-T therapy being evaluated in B cell non-Hodgkin lymphoma and large B cell lymphoma, and CB-011, an anti-BCMA CAR-T therapy for relapsed or refractory multiple myeloma.
Recurring announcements include clinical and translational data from the ANTLER and CaMMouflage trials, FDA designations and trial-design interactions, financial results, research and development spending, cash resources, pipeline prioritization, and medical or investor conference participation.
Caribou Biosciences announced promising long-term results from the ongoing ANTLER Phase 1 trial for its allogeneic CAR-T therapy, CB-010, targeting relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL). Twelve-month data show that 100% of patients in cohort 1 achieved a complete response, with two maintaining durable responses for up to 18 months. The FDA granted CB-010 RMAT and Fast Track designations, enhancing its development pathway. Currently, the trial is enrolling patients at a higher dose level, indicating positive progress in patient recruitment and potential therapeutic efficacy.
Caribou Biosciences, Inc. (Nasdaq: CRBU) has announced the target selection for its allogeneic anti-ROR1 CAR-NK cell therapy, CB-020, to be presented at the AACR-JCA Conference. The preclinical data suggests ROR1 could be a viable target for solid tumors, enhancing antitumor activity via innovative armoring strategies. These strategies aim to improve NK cell survival and efficacy against tough tumor environments. The research indicates significant tumor burden reduction with CB-020 compared to unmodified NK cells. This advancement highlights Caribou's utilization of its proprietary chRDNA CRISPR technology.
Caribou Biosciences (Nasdaq: CRBU) announced FDA has granted its CB-010 therapy both Regenerative Medicine Advanced Therapy (RMAT) and Fast Track designations for relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL). This therapy, the first allogeneic CAR-T with a PD-1 knockout, is undergoing the ANTLER Phase 1 trial. Three out of six patients had a durable complete response at six months. These designations aim to expedite development and regulatory review for promising treatments addressing significant patient needs.
Caribou Biosciences (CRBU) reported its Q3 2022 results, highlighting a strong financial position with $342.6 million in cash and marketable securities. The ANTLER Phase 1 trial for its lead therapy, CB-010, shows promising early safety and efficacy data for r/r B-NHL patients, with plans to share additional results by year-end. The company submitted an IND application for CB-011 targeting r/r MM and expects further milestones, including CB-020 target selection, in the upcoming months.
Caribou Biosciences (Nasdaq: CRBU) announced its participation in several upcoming investor conferences. Key events include:
- Barclays Gene Editing & Gene Therapy Summit on November 14, 2022
- Jefferies London Healthcare Conference on November 17, 2022
- 5th Annual Evercore ISI HealthCONx Conference on November 30, 2022
- BofA Securities Biotech SMID Cap Conference on December 7, 2022
Webcasts of these presentations will be available for 30 days post-event on Caribou's website.
Caribou Biosciences, Inc. (Nasdaq: CRBU) announced that its trial-in-progress abstract for the ANTLER Phase 1 clinical trial of CB-010, targeting relapsed or refractory B cell non-Hodgkin lymphoma, has been accepted for a poster presentation at the 64th ASH Annual Meeting from December 10-13, 2022, in New Orleans.
The presentation, by Dr. Susan O’Brien, will detail the trial design and objectives. CB-010 is an allogeneic CAR-T cell therapy employing CRISPR technology. The poster will be accessible on the ASH website and Caribou's website following the presentation.
Caribou Biosciences has reported a 15-month complete response in the first patient treated with CB-010 for relapsed or refractory aggressive B cell non-Hodgkin lymphoma. This case, presented at the Lymphoma, Leukemia, & Myeloma Congress, shows promising results following a single dose of CB-010. The patient, previously heavily treated, achieved and maintained a complete response since 28 days post-treatment. Caribou is advancing the ANTLER Phase 1 trial, now enrolling patients at a higher dose level, aiming to enhance the therapy's efficacy.
Caribou Biosciences, a clinical-stage CRISPR genome-editing biopharmaceutical company, announced its participation in several upcoming investor conferences. Significant events include:
- Citi 17th Annual BioPharma Conference on September 8, 2022, at 11:20 am ET
- H.C. Wainwright 24th Annual Global Investment Conference on September 13, 2022, at 10:00 am ET
- Morgan Stanley 20th Annual Global Healthcare Conference on September 13, 2022, at 4:40 pm ET
- Jefferies Cell and Genetic Medicines Summit on September 29-30, 2022
Caribou Biosciences (CRBU) reported significant progress in its clinical pipeline and a strong financial position with $366.1 million in cash as of June 30, 2022. The company achieved a 100% complete response rate in its CB-010 ANTLER Phase 1 trial for relapsed or refractory B cell non-Hodgkin lymphoma. Plans include enrolling more patients and submitting IND applications for CB-011 and CB-012 in late 2022 and 2023, respectively. Revenue from licensing and collaborations increased significantly, but R&D and G&A expenses also rose, leading to a net loss of $26.7 million for Q2 2022.
Caribou Biosciences (CRBU) reported promising results from its ANTLER Phase 1 trial for CB-010, an allogeneic CAR-T cell therapy. A 100% complete response (CR) rate was observed in six patients following a single dose, with 40% maintaining CR at six months. The first patient treated remained in CR for 12 months. The trial is now enrolling at a higher dosage, reflecting an initial positive safety profile and clinical activity. Additional data is expected by year-end 2022, suggesting potential advancements in CRISPR-edited therapies.