Cardiff Oncology Inc Stock Price, News & Analysis

On January 15, 2021, Cardiff Oncology (Nasdaq: CRDF) presented data on its investigational drug, onvansertib, at the ASCO-GI symposium. The Phase 1b/2 trial in KRAS-mutated metastatic colorectal cancer (mCRC) confirmed the recommended Phase 2 dose at 15 mg/m². Notable outcomes included a 42% partial response rate and 67% of patients showing durable responses lasting over 6 months. Initial findings from the Expanded Access Program mirrored these results, with 66% of patients demonstrating tumor shrinkage. The trial involves collaboration with prominent cancer centers.

Cardiff Oncology (Nasdaq: CRDF) announced the immediate resignation of Dr. Thomas Adams as Executive Chairman and Chairman of the Board, effective December 21, 2020. Dr. Rodney Markin has been appointed as the new Chairman. The board expressed gratitude for Dr. Adams' twelve years of leadership, which facilitated the company's transition from molecular diagnostics to drug development. With ongoing clinical programs targeting KRAS-mutated colorectal cancer, castration-resistant prostate cancer, and acute myeloid leukemia, the company aims to enhance treatment options for patients in need.

Cardiff Oncology (Nasdaq: CRDF) announced updated data from its Phase 1b/2 trial of onvansertib for relapsed/refractory acute myeloid leukemia (AML) at the 62nd ASH Annual Meeting. The oral presentation revealed that 20% of 45 patients achieved complete remission (CR/CRi), with 55% of responders having splicing factor mutations. Notably, the treatment showed promising safety and tolerability, with decreases in mutant ctDNA correlating with clinical responses. This data emphasizes onvansertib's potential impact in treating AML, addressing unmet medical needs.

Cardiff Oncology (Nasdaq: CRDF), a clinical-stage biotechnology company focused on developing cancer treatments, will participate in the Piper Sandler 32nd Annual Virtual Healthcare Conference. A pre-recorded fireside chat with the company's management will be available from November 23 to December 3. Additionally, Cardiff Oncology will conduct 1x1 meetings from December 1 to 3, requested exclusively through Piper Sandler. The company's investigational drug, onvansertib, targets multiple cancers, including KRAS-mutated colorectal cancer and castration-resistant prostate cancer.

Cardiff Oncology, Inc. (Nasdaq: CRDF) reported third quarter highlights and financial results for the period ending September 30, 2020. Key achievements include positive clinical data for onvansertib in treating KRAS-mutated colorectal cancer at the ESMO conference, showcasing a 91% disease control rate among participants. The company raised approximately $100 million from a public stock offering, enhancing its financial position for ongoing and new projects. As of September 30, it held $36.4 million in cash, with total operating expenses of $4.5 million for the quarter.

Cardiff Oncology (Nasdaq: CRDF) announced positive findings from its Phase 2 trial of onvansertib for metastatic castration-resistant prostate cancer (mCRPC) at the 27th Annual PCF Scientific Retreat. The trial showed that 31% of evaluable patients achieved disease control after 12 weeks, with a durable response noted in several cases. A gene signature biomarker was identified to predict patient response to the drug in combination with Zytiga® (abiraterone). Safety data indicated no significant issues across varying doses, reinforcing the potential of onvansertib to address drug resistance in mCRPC.

Cardiff Oncology, Inc. (Nasdaq: CRDF) has priced its underwritten public offering of 6,500,000 shares of common stock at $13.50 per share, aiming to raise approximately $88 million in gross proceeds. The offering is anticipated to close on or around October 2, 2020, pending customary conditions. Proceeds will be utilized for the clinical development of their drug candidate, onvansertib, alongside working capital and general corporate needs. Underwriters have a 30-day option to acquire an additional 975,000 shares at the offering price.

Cardiff Oncology (Nasdaq: CRDF) has initiated an underwritten public offering of its common stock. The company plans to grant underwriters a 30-day option to buy up to an additional 15% of shares sold. Proceeds from the offering will be directed towards the clinical development of onvansertib, working capital, and other corporate purposes. The offering is governed by a shelf registration statement effective from July 1, 2019. Cowen and Piper Sandler & Co. serve as joint book-running managers for this offering.

Cardiff Oncology (Nasdaq: CRDF) announced promising clinical data for onvansertib, a potential treatment for KRAS-mutated metastatic colorectal cancer (mCRC), presented at the ESMO Virtual Congress 2020. The trial showed that 91% of patients achieved disease control, with 45% attaining partial responses. Additionally, 73% exhibited durable responses lasting over six months. The study indicates that decreases in plasma KRAS mutation levels may predict tumor shrinkage. Onvansertib was well tolerated with no serious adverse effects reported, highlighting its potential as a second-line therapy for mCRC patients.