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Founded in 1947, Charles River Laboratories International, Inc. (symbol: CRL) is a global leader in providing essential products and services to pharmaceutical and biotechnology companies, government agencies, and academic institutions. The company's mission is to accelerate research and drug development efforts, significantly contributing to the healthcare industry.
Charles River operates through three main segments:
- Research Models & Services: This segment is renowned for being the leading provider of laboratory animal models. Charles River breeds and supplies animals with specific genetic traits for preclinical studies worldwide, supporting the critical early stages of drug discovery.
- Discovery & Safety Assessment: This segment offers a comprehensive range of services necessary for the early development of new drugs. From discovery services to safety assessments, Charles River helps clients navigate the complex process of taking a drug from concept to early-stage development.
- Manufacturing Support: This includes microbial solutions for in vitro testing, biologics testing services, and avian vaccine services. These services are integral to ensuring the safe manufacture and quality control of new therapies.
The company's workforce is dedicated to providing clients with the expertise and services they need to improve and expedite the discovery and development of new therapies. Charles River's collaborative approach and commitment to excellence have established it as a trusted partner in the life sciences industry.
Charles River continues to innovate and expand its services, making significant strides in the fields of drug discovery, biotechnology, and pharmaceuticals. With a strong financial footing and strategic partnerships, the company is well-positioned to support the future of healthcare advancements globally.
Charles River Laboratories (NYSE: CRL) and Autobahn Labs have announced a collaborative program to accelerate academic drug discovery. The agreement establishes Charles River as the preferred research partner for Autobahn Labs, providing access to its drug discovery and development capabilities. Key points include:
1. Charles River has made an equity investment in Autobahn Labs.
2. Justin Bryans, Charles River's Chief Scientific Officer of Discovery, joins Autobahn's Board of Directors.
3. The partnership aims to advance novel academic science into transformational therapies across various modalities and disease areas.
4. Autobahn gains preferred access to Charles River's state-of-the-art drug discovery and development capabilities.
5. The collaboration is expected to expand partnerships with top-tier academic institutions and advance preclinical programs.
Charles River Laboratories International (NYSE: CRL) has announced its schedule for the release of second-quarter 2024 financial results. The company will disclose its earnings on Wednesday, August 7th, before the market opens. Following the release, a conference call is planned for 9:00 a.m. ET on the same day to discuss the financial results.
Investors can access a live webcast of the conference call through the Investor Relations section of Charles River's website at ir.criver.com. For those unable to attend the live event, a replay will be made available on the same platform.
Charles River Laboratories and AAVantgarde have announced a CDMO agreement for the production of GMP plasmid DNA. AAVantgarde, a clinical-stage biotech firm, will use Charles River’s manufacturing expertise for their AAV-based gene delivery platforms, targeting inherited retinal diseases like Stargardt’s disease. This disease, affecting 1 in 6,500 people, causes progressive vision loss due to ABCA4 gene mutations. The collaboration will utilize Charles River’s GMP plasmid DNA center in Keele, UK, enhancing Charles River's cell and gene therapy portfolio and supporting AAVantgarde’s clinical trials.
Charles River Laboratories (NYSE: CRL) and the Gates Institute at the University of Colorado Anschutz Medical Campus have announced a strategic collaboration to develop and manufacture Good Manufacturing Practice (GMP)-grade lentiviral vectors (LVVs) for use in chimeric antigen receptor (CAR) T-cell therapies targeting hematological cancers.
The Gates Institute will leverage Charles River’s expertise in cell and gene therapy CDMO services to support its mission of advancing cellular and gene therapies. This partnership will utilize Charles River's manufacturing platforms and services, including process development, phase-appropriate research-grade and High-Quality plasmid DNA production, and GMP LVV manufacturing. Materials produced will support an upcoming Investigational New Drug (IND) application for Phase I clinical trials.
Charles River aims to expedite clinical and commercial manufacturing through standardized protocols and optimized methods, reducing development time and costs while ensuring high-quality production. This collaboration aligns with Charles River’s efforts to expand its cell and gene therapy portfolio and simplify complex supply chains.
Charles River Laboratories and Captain T Cell have announced a strategic alliance for the production of plasmid DNA and viral vectors to support T-cell immunotherapy clinical trials. This collaboration, part of Charles River's Cell and Gene Therapy (CGT) Accelerator Program, will leverage Charles River's extensive CDMO capabilities to aid Captain T Cell's development of TCR-T cell therapies for solid tumors. Captain T Cell focuses on creating T cells equipped with advanced tumor-specific receptors to treat patients whose tumors are unresponsive to existing treatments. Charles River's well-established production capabilities will streamline Captain T Cell's path from pre-clinical to commercial scale, aimed at enhancing the availability and efficacy of T-cell immunotherapies for cancer patients.
Charles River Laboratories (NYSE: CRL), in collaboration with MatTek , has secured a $1.3 million grant from the Foundation for Chemistry Research & Initiatives (FCRI) to develop a New Approach Methodology (NAM) for inhalation toxicology, aiming to reduce the reliance on animal testing. This multidisciplinary project involves Charles River’s Edinburgh team, MatTek’s in vitro EpiAirway™ model, dosimetry modeling by Battelle, and consultancy from Greek Creek Toxicokinetics. The initiative is part of Charles River's Alternative Methods Advancement Project (AMAP) and supported by the American Chemistry Council’s Long-Range Research Initiative (ACC LRI). The goal is to enhance chemical safety assessments and regulatory evaluations through innovative, non-animal testing methods.
Charles River Laboratories (NYSE: CRL) has announced the opening of a new Charles River Accelerator and Development Lab (CRADL®) facility in Somerville, Massachusetts. This AAALAC-accredited site provides flexible vivarium and laboratory space, addressing the growing demand within Massachusetts' biopharmaceutical sector. Strategically co-located with Nest.Bio, the new facility offers scalable contract vivarium space and access to Charles River's comprehensive drug discovery and non-clinical development resources. The facility's unique setup includes private lab suites, rentable lab benches, and office space on the same floor, fostering efficient communication and productivity. This is the fourth CRADL site in Massachusetts, joining nearly 30 facilities worldwide. The grand opening event is scheduled for July 31, 2024.
Charles River Laboratories (NYSE: CRL) has announced a collaboration with Sanofi to develop Virtual Control Groups (VCGs) in nonclinical toxicology. This initiative aims to reduce the use of animals in research by replacing some control group animals with data-driven virtual counterparts created from historical datasets. Guided by Charles River’s Alternative Methods Advancement Project (AMAP), this collaboration leverages machine learning and extensive data to generate meaningful study results without the need for as many animal subjects. The project is a pioneering effort to apply VCGs, commonly used in clinical trials, to preclinical research, involving partnerships with regulatory and biopharmaceutical leaders. The initiative aims to advance sustainable science in toxicology studies.
Charles River Laboratories (NYSE: CRL) will present at two upcoming conferences. The company will speak at the William Blair 44th Annual Growth Stock Conference on June 4th at 10:00 a.m. CT (11:00 a.m. ET) and at the Jefferies Global Healthcare Conference on June 5th at 10:00 a.m. ET. Management will discuss the company's strategic priorities, business developments, and industry trends. Live webcasts and replays will be available on the Investor Relations section of Charles River's website.
Charles River Laboratories has launched new Modular and Fast Track viral vector technology transfer frameworks. These frameworks are designed for seamless tech transfer to its Maryland-based viral vector Center of Excellence within nine months. The Fast Track framework allows for straightforward transfers when no process changes are needed, while the Modular framework supports complex transfers requiring process modifications. Both frameworks aim to prevent costly delays and ensure program success. Charles River's CoE offers full-scale capabilities for adeno-associated virus, adenovirus, lentivirus, and retrovirus production and integrates their concept-to-cure portfolio from discovery to commercialization.
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