Welcome to our dedicated page for Crinetics Pharmaceuticals news (Ticker: CRNX), a resource for investors and traders seeking the latest updates and insights on Crinetics Pharmaceuticals stock.
Crinetics Pharmaceuticals, Inc. (NASDAQ: CRNX) generates frequent news flow around its efforts to develop and commercialize therapies for endocrine diseases and endocrine-related tumors. Company announcements highlight progress across its GPCR-targeted small-molecule portfolio, including regulatory milestones, clinical trial updates, capital markets activity, and corporate developments.
News coverage often focuses on PALSONIFY™ (paltusotine), Crinetics’ once-daily, oral somatostatin receptor type 2 agonist. Updates have included U.S. FDA approval for adults with acromegaly who had an inadequate response to surgery and/or for whom surgery is not an option, early launch metrics, and the design and enrollment status of the pivotal Phase 3 CAREFNDR trial in carcinoid syndrome associated with neuroendocrine tumors.
Investors and observers can also follow regular announcements on atumelnant, the company’s investigational ACTH receptor antagonist in late-stage development for classic congenital adrenal hyperplasia (CAH) and ACTH-dependent Cushing’s syndrome. Press releases describe Phase 2 results, the CALM-CAH Phase 3 trial design, biomarker changes such as reductions in androstenedione, and safety observations from both core studies and open-label extensions.
Additional news items cover the advancement of CRN09682, a nonpeptide drug conjugate targeting SST2-expressing tumors, including first-patient dosing in the Phase 1/2 BRAVESST2 trial and details of the trial’s dose-escalation and expansion phases. Crinetics also reports on preclinical programs like CRN12755 and CRN10329 through R&D Day presentations and conference abstracts.
Beyond R&D, Crinetics issues releases on public offerings of common stock, inducement equity grants under its 2021 Employment Inducement Incentive Award Plan, participation in major healthcare conferences, and executive transitions disclosed via Form 8-K. For users tracking CRNX, this news page provides a centralized view of the company’s clinical, regulatory, financial, and corporate announcements over time.
Crinetics Pharmaceuticals (Nasdaq: CRNX) is set to host a webcast and conference call on March 30, 2021, at 4:30 p.m. ET, to discuss its 2020 financial results and clinical plans for 2021.
The company focuses on developing treatments for rare endocrine diseases, particularly its lead candidate, paltusotine, aimed at treating acromegaly. Crinetics plans to launch Phase 3 trials for paltusotine and a Phase 2 trial for carcinoid syndrome, alongside developing other investigational drugs.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced four presentations at the ENDO 2021 congress, showcasing significant advancements in their clinical pipeline. Key highlights include findings on CRN04894, an oral ACTH antagonist, and CRN04777, an SST5 agonist for congenital hyperinsulinism. The company shared promising preclinical data indicating CRN04894's potential in treating conditions like Cushing's disease. Additionally, results from the ACROBAT Edge Phase 2 study of paltusotine, an oral treatment for acromegaly, demonstrated efficacy in maintaining insulin-like growth factor-1 levels.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced its participation in the Endocrine Society’s ENDO 2021 congress, where it will showcase a new formulation of the paltusotine tablet, intended for Phase 3 studies. The company will present preclinical evidence supporting its programs for congenital hyperinsulinism and Cushing’s disease. Key presentations include improved pharmacokinetics of paltusotine and the efficacy of switching from injected to oral therapies. These developments highlight Crinetics’ commitment to advancing treatment options for rare endocrine diseases.
Crinetics Pharmaceuticals (Nasdaq: CRNX) has initiated a Phase 1 clinical trial for CRN04894, an adrenocorticotropic hormone (ACTH) antagonist designed to treat Cushing's disease and congenital adrenal hyperplasia (CAH). Following positive preclinical results, this randomized, placebo-controlled study will evaluate the drug's safety and tolerability in healthy volunteers. The trial aims to assess CRN04894's effectiveness in suppressing cortisol levels, a key biomarker for assessing treatments for these conditions. Successful outcomes could lead to a new therapeutic option for patients affected by excess ACTH.
Crinetics Pharmaceuticals (Nasdaq: CRNX) has initiated a Phase 1 study for CRN04777, an oral SST5 agonist aimed at treating congenital hyperinsulinism (HI). This rare disease causes excessive insulin production leading to life-threatening hypoglycemia. The study will assess safety and tolerability in healthy adults and evaluate CRN04777's capacity to suppress insulin secretion upon glucose or sulfonylurea stimulation. The FDA has granted this investigational drug a rare pediatric disease designation, highlighting its potential significance in addressing an under-served medical need.
Crinetics Pharmaceuticals (Nasdaq: CRNX) aims to advance its drug paltusotine to a Phase 3 trial for acromegaly in H1 2021. Additionally, two Phase 1 studies are set to commence in January and February 2021 for CRN04894 and CRN04777, targeting congenital adrenal hyperplasia and congenital hyperinsulinism, respectively. The company plans to highlight key priorities at the virtual J.P. Morgan Healthcare Conference on January 13, 2021. Crinetics continues to enhance its clinical teams, expanding to 90 employees, to support its growing pipeline of endocrine therapies, including new formulations of paltusotine.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced its participation in key conferences in December 2020. Management will present at the Evercore ISI 3rd Annual HealthCONx Conference on December 3rd, showcasing their innovations in oral drugs. Additionally, they will also feature in the Piper Sandler's 32nd Annual Healthcare Conference from December 1st to 3rd, with on-demand presentations available. The company focuses on developing novel therapeutics for rare endocrine diseases, with its lead candidate, paltusotine, targeting acromegaly and other conditions.
Crinetics Pharmaceuticals (Nasdaq: CRNX) appointed Dr. Peter Trainer as Vice President of Clinical Endocrinology. Dr. Trainer, a distinguished endocrine expert, will lead the Phase 3 development of paltusotine, a nonpeptide somatostatin receptor agonist aimed at treating acromegaly. His prior roles include significant positions in academia and healthcare organizations in the UK. Crinetics is also preparing to start clinical trials for a new nonpeptide ACTH antagonist for conditions like Cushing’s disease. The company focuses on innovative therapeutics for rare endocrine diseases.
Crinetics Pharmaceuticals (Nasdaq: CRNX) announced a webinar on November 20, 2020, at 11:00 AM ET, focusing on the oral therapy paltusotine for acromegaly. Key Opinion Leaders Dr. Peter Trainer and Dr. Monica Roberto Gadelha will discussing treatment landscapes and clinical insights following Phase 2 ACROBAT studies results. Crinetics plans to advance its Phase 3 program for paltusotine in the first half of 2021. The webinar will also include updates on other pipeline assets, including two anticipated Phase 1 trials.
Crinetics Pharmaceuticals (Nasdaq: CRNX) reported positive topline results for its ACROBAT Edge and Evolve Phase 2 trials of oral paltusotine for acromegaly. The drug maintained insulin-like growth factor-1 (IGF-1) levels in patients switching from injected therapies. The company also received Rare Pediatric Disease Designation for CRN04777, a treatment for congenital hyperinsulinism. Financially, R&D expenses rose to $13.7 million, with a net loss of $18.3 million. Cash reserves increased to $186.8 million, bolstered by an equity offering.
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