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Denali Therapeutics Inc. (DNLI) delivers breakthrough therapies targeting neurodegenerative and lysosomal storage diseases through its innovative blood-brain barrier platform. This page serves as the definitive source for DNLI news, offering investors and researchers timely updates on clinical advancements, regulatory milestones, and strategic collaborations.
Access curated press releases and analysis covering DNLI’s clinical trials, including programs for Parkinson’s disease, ALS, and rare genetic disorders. Track progress on the Transport Vehicle (TV) platform’s applications and partnerships shaping the future of CNS drug development.
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Denali Therapeutics reported its first quarter 2024 financial results, highlighting positive clinical data on various programs and achievements. The company remains focused on developing therapies for neurodegenerative and lysosomal storage diseases.
During the quarter, Denali presented positive two-year clinical data on tividenofusp alfa for MPS II, initiated a clinical trial for DNL126 in MPS IIIA, completed enrollment in the HEALEY ALS Platform Trial for DNL343, and made progress in various other programs like BIIB122/DNL151 for Parkinson's disease and SAR443122/DNL788 for multiple sclerosis.
Financially, Denali reported a net loss of $101.8 million, with a decrease in collaboration revenue due to certain collaborations. Total research and development expenses decreased primarily due to specific program milestones and operational changes.
The company also announced completion of a PIPE financing and divestiture of its preclinical small molecule portfolio. Denali ended the quarter with approximately $1.43 billion in cash, cash equivalents, and marketable securities.
Denali Therapeutics Inc. announced the completion of enrollment for Regimen G in the Phase 2/3 HEALEY ALS Platform Trial, evaluating their eIF2B agonist DNL343. The trial is a collaboration between the Sean M. Healey & AMG Center and the Northeast ALS Consortium. The completion of enrollment marks a significant milestone in the development of DNL343 for the treatment of ALS, with positive feedback from investigators and leaders in the field.
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