Welcome to our dedicated page for DURECT news (Ticker: DRRX), a resource for investors and traders seeking the latest updates and insights on DURECT stock.
The DURECT Corporation (DRRX) news feed on Stock Titan aggregates historical company announcements, clinical updates, financial disclosures and transaction-related communications for this former Nasdaq-listed biopharmaceutical issuer. DURECT has described itself as a late-stage biopharmaceutical company focused on epigenetic therapies that target dysregulated DNA methylation, with particular emphasis on serious and life-threatening conditions such as alcohol-associated hepatitis (AH) and other forms of acute organ injury.
News items for DRRX include detailed updates on the development of the company’s lead investigational drug candidate, larsucosterol. These releases cover milestones such as the Phase 2b AHFIRM trial results, publication of data in NEJM Evidence, presentations at major liver disease meetings, and plans for a registrational Phase 3 trial in severe AH. Company communications also highlight that larsucosterol has received Fast Track and Breakthrough Therapy designations from the U.S. Food and Drug Administration for the treatment of AH.
The feed also captures DURECT’s corporate and portfolio developments, including announcements about its FDA-approved non-opioid analgesic POSIMIR, based on the SABER platform technology, and the sale of the ALZET osmotic pump product line. In 2025, a significant portion of the news flow relates to the tender offer and merger under which a subsidiary of Bausch Health Americas, Inc. agreed to acquire all outstanding shares of DURECT, followed by completion of the merger and subsequent delisting and deregistration of DRRX.
Investors and researchers can use this page to review historical earnings releases, business updates, clinical trial communications and acquisition-related announcements that together document DURECT’s evolution from a publicly traded company to an indirect wholly owned subsidiary within a larger pharmaceutical group.
DURECT Corporation (Nasdaq: DRRX) has received Fast Track Designation from the FDA for its investigational drug DUR-928, aimed at treating alcoholic hepatitis (AH), a severe liver disease. This designation underscores the urgency for therapeutic options in this area. During a Phase 2a trial, DUR-928 showed a remarkable survival rate of 100% for patients at the 28-day follow-up, compared to a historical rate of 26%. DURECT plans to initiate a Phase 2b trial soon to expedite the development and potential approval of this promising treatment.
DURECT Corporation (Nasdaq: DRRX) announced a strategic agreement to sell its LACTEL Absorbable Polymer product line to Evonik for $15 million, with potential additional payments based on EBITDAS. The transaction is set to close by Q1 2021, pending customary conditions. This move allows DURECT to concentrate on developing DUR-928, aimed at treating alcohol-associated hepatitis and other liver diseases. Evonik will strengthen its healthcare solutions division through this acquisition, which aligns with its growth agenda in advanced drug delivery and biomaterials.
DURECT Corporation (Nasdaq: DRRX) presented promising results from its Phase 1b clinical trial of DUR-928 for nonalcoholic steatohepatitis (NASH) at The AASLD Liver Meeting Digital Experience 2020. Key findings include a significant reduction in cytokeratin-18 levels and improved biomarkers for liver health, particularly in patients with at least a 10% reduction in liver fat. DUR-928 demonstrated good tolerability across all doses and outperformed traditional metrics like liver enzymes and imaging. The study involved 65 patients completing a 4-week treatment regimen.
DURECT Corporation (Nasdaq: DRRX) announced that Dr. Norman Sussman, the new Chief Medical Officer, will host a webinar on November 20, 2020, at 1:00 pm ET. The session will discuss the treatment of alcoholic hepatitis (AH) and DURECT's investigational drug, DUR-928, aimed at addressing this condition. DUR-928 is currently evaluated in the Phase 2b AHFRIM trial. This drug is designed to modulate critical gene expressions, enhancing cell survival and reducing inflammation. Following the presentation, Dr. Sussman will answer audience questions.
DURECT Corporation (Nasdaq: DRRX) reported Q3 2020 revenues of $2.7 million, down from $10.8 million in Q3 2019, with a net loss of $9.3 million compared to a loss of $2.0 million in the prior year. Cash and investments decreased to $49.8 million from $64.8 million at the end of 2019. The company is advancing the clinical trials for DUR-928, targeting conditions like Alcoholic Hepatitis, COVID-19, and NASH. The Phase 2b trial for Alcoholic Hepatitis will start dosing shortly, with potential implications for FDA approval.
DURECT Corporation (Nasdaq: DRRX) has appointed Dr. Norman Sussman as Chief Medical Officer, effective immediately. Dr. Sussman will guide the clinical development of the company's lead drug candidate, DUR-928, targeting conditions like alcoholic hepatitis (AH) and nonalcoholic steatohepatitis (NASH). With over 30 years in liver disease clinical research, his expertise is expected to enhance DURECT's efforts as it prepares for a pivotal Phase 2b trial in AH. The company aims to transform treatments for acute organ injury and chronic liver diseases with DUR-928, an innovative epigenetic regulator.
DURECT Corporation (Nasdaq: DRRX) will announce its third quarter 2020 financial results on November 2, 2020, at 4:30 PM ET. A conference call will follow, providing key updates on their clinical programs, including DUR-928, an investigational drug targeting acute organ injury and chronic liver diseases. DUR-928 is currently in Phase 2 trials for alcoholic hepatitis and COVID-19 related injuries, and Phase 1 for nonalcoholic steatohepatitis. The company is also advancing POSIMIR, a pain relief solution.
DURECT Corporation (Nasdaq: DRRX) will participate in the ROTH Capital Healthcare Event titled Covid-19 Therapeutics in Development on October 28, 2020. The webinar will cover various therapeutic sessions aimed at treating COVID-19. DURECT’s lead candidate, DUR-928, is in Phase 2 development for treating alcoholic hepatitis and COVID-19 patients with acute liver or kidney injury. Additionally, POSIMIR is being developed for post-surgery pain relief. The press release highlights potential risks in clinical development and FDA approval processes.
DURECT Corporation (Nasdaq: DRRX) announced its participation in the AASLD Liver Meeting Digital Experience 2020, presenting findings from its Phase 1b clinical trial of DUR-928 in nonalcoholic steatohepatitis (NASH) patients. Topline results indicated a 43% reduction in liver fat in patients, showing overall improvement in liver enzymes and lipid profiles. The study demonstrated safety across all dosing regimens. Further safety and efficacy data will be available during the meeting, enhancing understanding of DUR-928 as a potential treatment for liver diseases.
DURECT Corporation (Nasdaq: DRRX) announced participation in a fireside chat on October 5, 2020, from 2:30 p.m. to 3:00 p.m. EDT. Key executives, including President and CEO James E. Brown, CFO Michael H. Arenberg, and EVP of R&D Dr. WeiQi Lin, will join host Ed Arce from H. C. Wainwright. Investors can view the live webcast on DURECT's homepage under the 'Investors' tab or directly here. The company focuses on developing therapies for liver diseases and acute organ injury.
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