Welcome to our dedicated page for Defence Therapeu news (Ticker: DTCFF), a resource for investors and traders seeking the latest updates and insights on Defence Therapeu stock.
Defence Therapeutics Inc. (OTCQB: DTCFF) generates news primarily around its work as a biotechnology company specialized in drug delivery technologies and next-generation antibody-drug conjugates (ADCs). Company updates frequently highlight progress with its proprietary ACCUM® intracellular delivery platform, which Defence Therapeutics describes as enabling precision delivery of biologics and ADCs to target cells and enhancing efficacy and potency against cancer.
News coverage for Defence Therapeutics often focuses on scientific and preclinical milestones. The company has reported laboratory validations and preclinical in vivo studies of Accum®-enhanced ADCs, including comparative data in HER2-positive breast cancer models. Releases describe how ACCUM® can improve intracellular delivery, overcome endosomal entrapment, and increase the therapeutic index of ADCs, which the company associates with the potential for more effective and better-tolerated cancer therapies.
Another key theme in Defence Therapeutics news is its engagement with the global biopharma community. The company announces participation in events such as the World ADC Conference in San Diego and CPHI Worldwide in Frankfurt, where it presents new data, meets potential partners, and interacts with collaborators and shareholders. Updates also cover the formation of a Scientific Advisory Board to guide Accum®-enabled ADC programs and the appointment of leadership roles focused on quality and operations.
Investors and observers following DTCFF news will also see corporate and capital markets developments, including reports on convertible debenture conversions, stock option grants, warrant term amendments, marketing service engagements, and outcomes of annual general meetings. This news page brings together these scientific, strategic, and corporate updates so readers can track how Defence Therapeutics advances its ACCUM® platform and ADC-focused biotechnology strategy over time.
Defence Therapeutics (OTCQB:DTCFF) deepened its collaboration with Canadian Nuclear Laboratories to accelerate its proprietary radiopharmaceutical pipeline. The expanded partnership will initiate multiple radioisotope programs using Defence's Accum platform as lead program data aim to support candidate selection and prepare for first-in-human studies.
The move positions Defence to broaden radiopharmaceutical assets alongside its ADC work and leverage CNL nuclear science expertise to advance programs toward the clinic.
Defence Therapeutics (OTCQB: DTCFF) said it is repositioning as a precision intracellular drug-delivery company centered on its proprietary Accum platform.
The company says Accum enhances cellular uptake and payload release to boost therapeutic potency at lower doses and potentially reduce toxicity. Defence plans a dual strategy of internal R&D plus strategic partnerships to apply Accum to antibody-drug conjugates, radiopharmaceuticals and other complex biologics, with the stated goal of enabling safer, earlier-line cancer treatments and creating scalable value for partners and shareholders.
Defence Therapeutics (OTCQB: DTCFF) reported results from its December 10, 2025 annual meeting and provided corporate updates.
Shareholders approved a five-member board and ratified Crowe MacKay as auditors. The company granted 800,000 stock options exercisable at $0.82 for 10 years. Defence amended 967,000 warrants from private placements, extending expiry by 12 months and repricing exercise price from $2.00 to $1.00 (new expiries Jan 30, 2027 and Mar 22, 2027).
Defence disclosed a marketing services agreement with i2i Marketing Group for USD $300,000, starting ~Nov 3, 2025, with $50,000 paid on signing and remaining payments tied to completion conditions.
Defence Therapeutics (OTCQB: DTCFF) announced formation of its inaugural Scientific Advisory Board (SAB) on December 4, 2025, appointing Rob Leanna, Danny Chui, and Brendan Hussey.
The company said its Accum®-enhanced ADC program reached laboratory validations showing increased intracellular accumulation and improved efficacy for Accum-enhanced ADCs. The SAB will provide scientific, technical, and strategic guidance across CMC, antibody engineering, preclinical pharmacology, translational biology, and partnering to support progression toward clinical development and scale.
Defence Therapeutics (OTCQB:DTCFF) announced that holders of its 8% convertible debentures issued November 16, 2024, converted all principal and accrued interest into common shares upon maturity on November 16, 2025.
The principal amount of $1,476,000 converted into 2,460,000 shares at a conversion price of $0.60 per share, and $118,080 of accrued interest converted into 147,600 shares at $0.80 per share, totalling 2,607,600 shares and an aggregate amount of $1,594,080.
Defence Therapeutics (OTCQB: DTCFF) announced a strategic shift to supply its proprietary Accum drug‑delivery platform to antibody‑drug conjugate (ADC) developers after presenting at the World ADC Conference and CPHI.
Defence reported completed preclinical studies showing Accum‑conjugated Kadcyla produced ~20‑fold higher anti‑tumor efficacy than Kadcyla alone at the same 0.5 mg/kg dose in JIMT‑1 HER2+ mouse xenografts, with a near‑complete response in 90% of mice.
The company is engaging ADC partners to license or supply Accum for improving potency and reducing toxicity across ADC programs.
Defence Therapeutics (OTCQB:DTCFF) presented new preclinical data on its proprietary Accum platform at the 16th World ADC Conference in San Diego (November 4-5, 2025).
Presenters said Accum enhanced intracellular delivery and payload release in ADCs, improving potency and therapeutic index in the data shown. Defence announced plans to expand collaborative and internal testing of Accum across multiple commercial and clinical-stage ADC constructs to evaluate plug-and-play applicability across different antibodies and payloads.
The company indicated active engagement with industry partners to accelerate evaluations and explore potential benefits for targeted cancer therapies.
Defence Therapeutics (OTCQB: DTCFF) reported preclinical in vivo results for Accum-Kadcyla in HER2-positive breast cancer mouse models on November 4, 2025.
The study found ~20-fold higher anti-tumor efficacy for Accum-Kadcyla versus Kadcyla at the same dose 0.5 mg/kg, with tumor growth largely halted and a durable near-complete response in most treated mice. 100% survival and no signs of toxicity were reported during the study. Defence plans additional HER2-positive and HER2-low model testing and to advance partner discussions.
Defence Therapeutics (OTCQB: DTCFF) will present new scientific data on its Accum technology at the 16th World ADC Conference in San Diego on November 4-5, 2025.
The presentation highlights Accum's role in improving intracellular delivery and endosomal escape for antibody-drug conjugates (ADCs), aiming to enhance potency and reduce off-target toxicity. Company scientists Maxime Parisotto and Mark Lambermon will be available at the poster in the Conference Exhibition Hall, Town & Country Resort, to discuss the results and ongoing R&D.
Defence Therapeutics (OTCQB: DTCFF) will attend CPHI Worldwide 2025 in Frankfurt, Germany from October 28-30, 2025, the company stated on October 6, 2025. According to the press release, Defence plans to engage potential partners across the biopharma value chain, learn about pharmaceutical manufacturing trends, and connect with international collaborators and shareholders.
The company also invited attendees to an informal Meet & Greet on October 29, 2025 from 4:30–6:30 PM at the American May lobby bar of the Kimpton Hotel in Frankfurt and listed contact options via the CPHI partnering platform and LinkedIn for named company representatives.
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