Welcome to our dedicated page for Precision Biosciences news (Ticker: DTIL), a resource for investors and traders seeking the latest updates and insights on Precision Biosciences stock.
News and updates for Precision BioSciences, Inc. (Nasdaq: DTIL) center on its progress as a clinical stage gene editing company using the ARCUS platform to develop in vivo therapies for serious genetic and infectious diseases. Company announcements frequently highlight developments in its pipeline, clinical trial milestones, scientific publications, and capital markets activity.
A major focus of Precision’s news flow is PBGENE-HBV, the company’s wholly owned in vivo gene editing program for chronic hepatitis B. Updates include data from the global ELIMINATE-B trial, covering safety, dose-dependent antiviral activity, reductions in hepatitis B surface antigen (HBsAg), and biopsy evidence of ARCUS-mediated viral DNA editing. Press releases also describe regulatory designations such as Breakthrough Therapy status and the expansion of clinical trial sites across multiple countries.
Another recurring theme is PBGENE-DMD, a muscle-targeted excision program for Duchenne muscular dystrophy. News items discuss preclinical data on dystrophin restoration and functional muscle improvement, preparations for investigational new drug (IND) submissions, and plans for Phase 1/2 clinical studies in DMD patients with mutations in exons 45–55 of the dystrophin gene.
Investors can also find updates on partnered in vivo programs, such as ECUR-506 for neonatal onset OTC deficiency developed by iECURE using a licensed ARCUS nuclease, along with regulatory milestones like RMAT designation. Additional coverage includes progress in non-core ex vivo programs such as azer-cel, an allogeneic CAR T therapy being advanced by partners for lymphoma and autoimmune diseases.
Financial and corporate news, including quarterly results, equity offerings, and strategic priorities, round out the DTIL news stream. For those tracking gene editing, hepatitis B, DMD, and ARCUS-based therapies, this page provides an organized view of Precision BioSciences’ latest disclosures and clinical developments over time.
Precision BioSciences has entered a significant collaboration with Novartis to develop a specialized ARCUS nuclease for in vivo gene editing, targeting diseases like sickle cell disease and beta thalassemia. Precision will receive an upfront payment of
Precision BioSciences (DTIL) reported promising updates from its allogeneic CAR T pipeline, especially for PBCAR0191, which achieved a 100% overall response rate and a 73% complete response rate among evaluable CAR T relapsed patients. The company also noted a 50% durable response lasting over six months. Progress continues in the PBCAR19B and PBCAR269A programs, with a manufacturing optimization for PBCAR19B and advancements in the ongoing PBCAR269A study. Financially, the company had approximately $121 million in cash as of May 31, 2022.
Precision BioSciences, Inc. (Nasdaq: DTIL) announced a webcast and conference call on June 8, 2022, at 8:00 AM ET to update on its allogeneic CAR T programs. The company aims to share the latest clinical data on its lead candidate, PBCAR0191, designed for patients who have relapsed after CAR T therapy. Chief Medical Officer Alan List emphasized the significant unmet need in the CAR T relapse area.
Precision BioSciences is focused on developing innovative gene editing therapies using ARCUS technology to address genetic disorders and enhance patient treatment options.
Precision BioSciences, Inc. (NASDAQ: DTIL) announced its participation in the Jefferies Healthcare Conference from June 8-10, 2022. The in-person fireside chat will occur on June 9 at 4:00 PM ET at the New York Marriott Marquis. A live webcast of the event will be accessible on the company’s website, with an archived replay available for 30 days post-event. Precision BioSciences specializes in gene editing therapies using its proprietary ARCUS® platform, focusing on CAR T immunotherapy and gene editing candidates to treat genetic diseases.
Precision BioSciences, Inc. (NASDAQ: DTIL) announced the approval of inducement awards under its 2021 Employment Inducement Incentive Award Plan for new employees. This includes options to purchase 916,416 shares and 199,454 restricted stock units (RSUs). The stock options have an exercise price of $1.68 and a 10-year term, vesting at 25% after one year and the remaining 75% quarterly over three years. The RSUs vest on the first anniversary. These awards aim to attract talent critical for advancing its ARCUS® gene editing therapies.
Precision BioSciences (NASDAQ: DTIL) has appointed Melinda Brown to its Board of Directors and as Chair of the Audit Committee. Ms. Brown brings extensive experience in finance and risk management from previous roles at large public companies, including Tapestry, Inc. and PepsiCo, Inc. This addition marks the fifth new board member since April 2021, enhancing the board's diverse expertise. Brown expressed enthusiasm for joining a company focused on addressing unmet medical needs through its ARCUS genome editing platform.
Precision BioSciences (NASDAQ: DTIL) has appointed Juli Blanche as Chief People Officer, bringing over 25 years of HR leadership, particularly in the pharmaceutical industry. Previously with Bristol-Myers Squibb, she oversaw a workforce of 11,000 as Senior Vice President, HR Business Partner. CEO Michael Amoroso expressed optimism about her role in enhancing the company's people-focused culture and leadership. Blanche aims to leverage her experience to foster an innovative environment at Precision BioSciences, aimed at advancing gene editing therapies.
Precision BioSciences (DTIL) announced promising preclinical results for its ARCUS gene editing platform aimed at hepatitis B virus (HBV). Key findings include an 85% reduction in cccDNA and a 77% drop in HBsAg in HBV-infected human hepatocytes. The research also showed a 96% decrease in circulating HBsAg in animal models. Collaborating with Gilead Sciences and Acuitas Therapeutics, Precision plans to submit an IND application for its PBGENE-HBV candidate in 2024, marking a potential advancement in HBV treatment options.
Precision BioSciences (Nasdaq: DTIL) presented promising preclinical data on its ARCUS genome editing platform at the ASGCT conference (May 16-19, 2022). Key findings include:
- 98% knockdown of HAO1 protein in non-human primates related to Primary Hyperoxaluria Type 1.
- 85% degradation of Hepatitis B virus cccDNA and 77% reduction in HBsAg levels.
- Successful gene insertion approach for OTC deficiency in NHPs, with stable editing results.
The company plans to advance three product candidates to clinical trials over the next three years.
On May 6, 2022, Precision BioSciences (NASDAQ: DTIL) announced the grant of inducement awards under its 2021 Employment Inducement Incentive Award Plan. These awards consist of stock options totaling 401,905 shares, granted to four new employees who started on March 14, 2022. The options have an exercise price of $1.94, equal to the fair market value on the grant date, and a 10-year term with a vesting schedule. Precision BioSciences focuses on developing ARCUS-based gene editing therapies aimed at treating genetic and infectious diseases.
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