Devonian Advances Thykamine™ Patent Strategy with Proprietary Fingerprint and Robust Manufacturing Controls
Rhea-AI Summary
Devonian (OTCQB: DVHGF) announced that a proprietary Thykamine™ fingerprint has been filed in two patent applications and will be used in all future Thykamine filings. The fingerprint defines eight chemical components in precise ratios using HPLC‑MS, with NMR confirmation showing ≥98% batch‑to‑batch confidence.
Biological potency assays in a U‑937 human cell model demonstrated equivalent activity across batches, including consistent inhibition of inflammatory cytokines RANTES and MIP‑1β. The fingerprint, NMR, and potency assays are being integrated into Thykamine's CMC framework to support pharmaceutical development and regulatory preparedness.
Positive
- Proprietary Thykamine fingerprint filed in two patent applications
- HPLC‑MS fingerprint defines 8 components in precise ratios
- NMR confirmation indicates ≥98% batch‑to‑batch chemical consistency
- Potency assays show equivalent biological activity across batches
- Analytical and biological controls to form Thykamine CMC framework
Negative
- Potency assay is still being validated for formal inclusion in CMC
- Patent filings are initial; no patent grants or approvals reported yet
News Market Reaction – DVHGF
On the day this news was published, DVHGF gained 149.65%, reflecting a significant positive market reaction.
Data tracked by StockTitan Argus on the day of publication.
The Thykamine™ fingerprint defines eight specific chemical components present in precise ratios, established using advanced HPLC-MS (High-Performance Liquid Chromatography–Mass Spectrometry) analytical methods. The HPLC-MS methodology has demonstrated high reproducibility across manufactured batches of Thykamine™, a result independently confirmed by NMR (Nuclear Magnetic Resonance) analysis, showing ≥
Batch reproducibility was further validated through potency assays using a U-937 human cell-based model, demonstrating that every batch of Thykamine™ exhibits equivalent biological activity. These assays confirmed consistent inhibition of key inflammatory cytokines, including RANTES and MIP-1β, reinforcing the functional equivalence of each production batch. The potency assay is currently being validated for inclusion in the Chemistry, Manufacturing and Controls (CMC) section of Thykamine™ production.
Collectively, the HPLC-MS fingerprinting, NMR confirmation, and potency assays will form an integral part of Devonian's CMC framework for Thykamine™ production, reinforcing regulatory preparedness and ensuring the level of manufacturing robustness required for pharmaceutical development.
Dr. André Boulet, Chief Executive Officer of Devonian, commented: "These analytical and biological methods clearly demonstrate the quality and consistency of Thykamine™ produced in every batch—not only from a chemical standpoint, but also as an active anti-inflammatory and anti-fibrotic pharmaceutical. This integrated approach provides strong confidence that patients will consistently receive a product of the same high quality, efficacy, and reliability."
This milestone reinforces Devonian's commitment to scientific rigor, intellectual property protection, and pharmaceutical-grade manufacturing as the Company continues to advance Thykamine™ through development.
About Thykamine™
Thykamine™, the first pharmaceutical product issued from Devonian's SUPREX™ platform, is a highly innovative product for the prevention and treatment of health conditions related to inflammation and oxidative stress including ulcerative colitis, atopic dermatitis, psoriasis, rheumatoid arthritis, and other autoimmune disorders. The anti-inflammatory, anti-oxidative and immunomodulatory properties of Thykamine™ have been demonstrated by a considerable number of in vitro and in vivo studies as well as in a Phase IIa clinical study in patients with mild-to-moderate distal ulcerative colitis and in a large Phase II study in adult patients with mild-to-moderate Atopic Dermatitis. Both Thykamine™ and SUPREX™ platform are covered by patents issued in several North American, European and Asian countries.
About Devonian
Devonian Health Group Inc. is a clinical stage pharmaceutical company specializing in the development of drugs for various auto-immune fibroinflammatory disease with novel therapeutic approaches to targeting unmet medical needs. Devonian's core strategy is to develop prescription drugs for the treatment of fibroinflammatory autoimmune diseases including but not limited to atopic dermatitis, radiodermatitis and ulcerative colitis.
Devonian is also involved in the development of high-value cosmeceutical products leveraging the same proprietary approach employed with their pharmaceutical offerings. Devonian also owns a commercialization subsidiary, Altius Healthcare LP, focused on selling prescription pharmaceutical products in
Devonian Health Group Inc. was incorporated in 2015 and is headquartered in
For more information, visit www.groupedevonian.com.
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SOURCE Devonian Health Group Inc.