Eledon Pharmaceuticals Reports Fourth Quarter and Full Year 2025 Operating and Financial Results
Rhea-AI Summary
Eledon Pharmaceuticals (Nasdaq: ELDN) reported 2025 operational and financial results on March 19, 2026, highlighting clinical progress for tegoprubart.
Key points: FDA Orphan Drug designation for liver transplantation, 24-month kidney transplant eGFR rose from 67.0 to 74.2 mL/min/1.73 m², islet transplant results showed 10/10 patients >4 weeks insulin independent (mean HbA1c ~5.35%), R&D $66.3M, net loss $45.6M ($0.52/share); adjusted net loss $79.1M.
Positive
- FDA Orphan Drug designation for liver transplantation
- Kidney transplant eGFR improvement from 67.0 to 74.2 mL/min/1.73 m²
- 10 of 10 post‑transplant islet patients >4 weeks achieved insulin independence
- Mean HbA1c ~5.35% in most recent islet transplant assessments
Negative
- R&D expenses increased 27% to $66.3 million in 2025
- Reported net loss widened to $45.6 million in 2025
- Adjusted net loss excluding warrant gains was $79.1 million
Key Figures
Market Reality Check
Peers on Argus
ELDN is up 4.17% on earnings and clinical updates, while scanner peers are split (ACHV up, ACOG down) and broader biotech peers show mixed moves, suggesting a stock-specific reaction rather than a sector-wide trade.
Previous Earnings Reports
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Nov 14 | Q3 2025 earnings | Positive | -8.0% | Phase 2 BESTOW data and equity raise expanded resources for tegoprubart programs. |
| Aug 14 | Q2 2025 earnings | Positive | +1.1% | Positive Phase 1b kidney data and solid cash balance supported development plans. |
| May 14 | Q1 2025 earnings | Positive | +2.1% | Strong cash position and progress using tegoprubart in xenotransplantation. |
| Mar 20 | FY 2024 results | Positive | +2.0% | Major transplant milestones and an oversubscribed offering bolstered balance sheet. |
| Nov 12 | Q3 2024 earnings | Positive | -11.4% | Completed BESTOW enrollment, early islet data, and large non-cash-driven net income. |
Earnings updates tied to tegoprubart and financings have produced mixed reactions, with several positive-readout quarters selling off despite constructive clinical and cash updates.
Over the past five earnings or annual updates from Nov 2024 through Nov 2025, Eledon repeatedly highlighted progress for tegoprubart in kidney and islet transplantation alongside capital raises that extended cash runway into 2026. Clinical data generally showed favorable eGFR and safety, while offerings and non-cash warrant gains shaped reported P&L. Price reactions were mixed: some quarters with strong trial and cash updates traded down, others modestly higher. Today’s full year 2025 report continues that pattern of advancing tegoprubart with higher R&D and a wider net loss.
Historical Comparison
Past earnings/annual updates moved ELDN an average of -2.81%. Today’s +4.17% post-earnings gain marks a stronger-than-typical reaction.
Earnings updates have tracked tegoprubart’s path from Phase 1b and Phase 2 BESTOW kidney data, through growing islet transplant experience and repeated financings that extended cash runway into 2026.
Market Pulse Summary
This announcement combines full year 2025 financials with detailed tegoprubart data in kidney, islet, and liver transplant settings. Key takeaways include higher R&D spending of $66.3 million, a net loss of $45.6 million, and strong insulin-independence rates in the UChicago islet trial. Historically, earnings updates have produced mixed stock reactions. Investors may focus on future regulatory interactions, Phase 3 kidney trial design, and capital needs as development progresses.
Key Terms
orphan drug designation regulatory
phase 1b medical
phase 2 medical
phase 3 medical
hbA1c medical
AI-generated analysis. Not financial advice.
Reported updated results from 12 patients with type 1 diabetes treated with tegoprubart following islet transplantation in UChicago Medicine-led study
Presented 24-month follow-up data from Phase 1b long-term extension study which continues to support the favorable safety and tolerability profile of tegoprubart
Tegoprubart granted Orphan Drug designation by the FDA for the prevention of allograft rejection in liver transplantation
IRVINE, Calif., March 19, 2026 (GLOBE NEWSWIRE) -- Eledon Pharmaceuticals, Inc. (“Eledon”) (Nasdaq: ELDN) today reported its fourth quarter and full year 2025 operating and financial results and reviewed recent business highlights.
“Over the past year, Eledon has made significant progress advancing tegoprubart, our anti-CD40L antibody, as a potential next-generation immunosuppressive therapy across multiple transplantation settings,” said David-Alexandre C. Gros, M.D., Chief Executive Officer of Eledon. “The over 100 patients treated across our transplantation programs to date provide a growing body of evidence that reinforces our conviction that tegoprubart can address key safety and efficacy issues with current standard-of-care transplant immunosuppression. Looking ahead, we anticipate multiple important milestones this year, including regulatory engagement to support advancement into Phase 3 development in kidney transplantation, initiation of an additional islet transplantation trial in type 1 diabetes, and the start of a clinical trial in liver transplantation.”
Fourth Quarter 2025 and Recent Corporate Developments
- Announced that tegoprubart has been granted Orphan Drug designation by the U.S. Food and Drug Administration (FDA) for the prevention of allograft rejection in liver transplantation. Tegoprubart previously received Orphan Drug designation from the FDA for the prevention of allograft rejection in pancreatic islet cell transplantation and for the treatment of amyotrophic lateral sclerosis (ALS).
- Presented 24-month follow-up data from eight patients enrolled in the Phase 1b long-term extension trial evaluating tegoprubart in kidney transplantation at the American Society of Transplant Surgeons Winter Symposium. The data continue to support the favorable safety and tolerability profile of tegoprubart with no episodes of biopsy-proven acute rejection, graft loss, death, new-onset diabetes mellitus, or de novo donor-specific antibody formation reported during the study period. Mean estimated glomerular filtration rate (eGFR) increased over the measurement period, from 67.0 mL/min/1.73 m² at 12 months to 74.2 mL/min/1.73 m² at 24 months.
- Reported updated results from 12 patients with type 1 diabetes treated with tegoprubart as the core immunosuppressant following islet transplantation in an investigator-initiated trial conducted at the University of Chicago Medicine Transplant Institute. All 10 patients who were more than four weeks post-transplant achieved
100% insulin independence and a most recent hemoglobin A1C (HbA1c) below6.0% , with a mean most recent HbA1c across the 10 patients of approximately5.35% . Tegoprubart-based immunosuppression was generally well tolerated with reported post-transplant immunosuppression-related adverse events successfully treated by lowering the mycophenolic acid dose, if necessary. There were no rejection episodes, and no patients developed de novo donor-specific HLA antibodies. Additionally, no evidence of nephrotoxicity, hypertension or neurotoxicity, which are commonly associated with tacrolimus-based immunosuppression regimens, was observed. The study continues to generate significant patient demand with inquiries received from several hundred T1D patients.
Anticipated Upcoming Milestones
- Receive FDA guidance on the Phase 3 trial design assessing tegoprubart in kidney transplantation, followed by initiation of the Phase 3 trial pending regulatory alignment.
- Report long-term data from Phase 1 and Phase 2 BESTOW studies evaluating tegoprubart in kidney transplantation.
- Receive FDA regulatory guidance on path to market for tegoprubart in islet cell transplantation and xenotransplantation.
- Initiate an investigator-led study evaluating tegoprubart for the prevention of organ rejection in patients with renal dysfunction receiving an islet cell transplant.
- Initiate an investigator-led study evaluating tegoprubart for the prevention of organ rejection in patients receiving a de novo liver transplant.
- Initiate an investigator-led study evaluating tegoprubart for kidney transplant tolerance induction.
Full Year 2025 Financial Results
Research and development (R&D) expenses for the year ended December 31, 2025 were
General and administrative expenses for the year ended December 31, 2025 were
Net loss for the year ended December 31, 2025 was
About Eledon Pharmaceuticals and tegoprubart
Eledon Pharmaceuticals, Inc. is a clinical stage biotechnology company that is developing immune-modulating therapies for the management and treatment of life-threatening conditions. The Company’s lead investigational product is tegoprubart, an anti-CD40L antibody with high affinity for the CD40 Ligand, a well-validated biological target that has broad therapeutic potential. The central role of CD40L signaling in both adaptive and innate immune cell activation and function positions it as an attractive target for non-lymphocyte depleting, immunomodulatory therapeutic intervention. The Company is building upon a deep historical knowledge of anti-CD40 Ligand biology to conduct preclinical and clinical studies in kidney allograft transplantation, xenotransplantation, islet cell transplantation, liver transplantation and amyotrophic lateral sclerosis (ALS). Eledon is headquartered in Irvine, California. For more information, please visit the Company’s website at www.eledon.com.
Follow Eledon Pharmaceuticals on social media: LinkedIn; Twitter
Forward-Looking Statements
This press release contains forward-looking statements that involve substantial risks and uncertainties. Any statements about the company’s future expectations, plans and prospects, including statements about planned clinical trials, the development of product candidates, expected timing for initiation of future clinical trials, expected timing for receipt of data from clinical trials, the company’s capital resources and ability to finance planned clinical trials, as well as other statements containing the words “believes,” “anticipates,” “plans,” “expects,” “estimates,” “intends,” “predicts,” “projects,” “targets,” “looks forward,” “could,” “may,” and similar expressions, constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are inherently uncertain and are subject to numerous risks and uncertainties, including: our short operating history and shifts in our business strategy; our operating losses since inception; our need for additional funding to develop our lead drug candidate and our ability to secure additional funding on acceptable terms or at all; the impact of issuances of our common stock, including in the possibility of dilution or a decline in our stock price; our ability to successfully develop our product candidates; unfavorable global economic and financial market conditions; the regulatory environment of our business and our ability to obtain required regulatory approvals; results of non-clinical studies and clinical trials, and risks that non-clinical studies or early clinical trials may not be predictive of results of later-stage clinical trials; delays or difficulties in enrollment of patients in clinical trials; our ability to attract and retain our executives and key employees; legislation of the pharmaceutical and healthcare industries; cybersecurity and data privacy risks; the ability of our products to achieve marketing approval; competition in our industry; our ability to obtain insurance coverage; our dependence on contract research organizations; our ability to protect our intellectual property; public health crises; our ability to maintain proper and effective internal control over financial reporting and other risks disclosed in our Annual Report on Form 10-K for the year ended December 31, 2025, filed with the Securities and Exchange Commission on March 19, 2026. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors. These risks and uncertainties, as well as other risks and uncertainties that could cause the company’s actual results to differ materially from the forward-looking statements contained herein, are discussed in our Annual 10-K, and other filings with the U.S. Securities and Exchange Commission, which can be found at www.sec.gov. Any forward-looking statements contained in this press release speak only as of the date hereof and not of any future date, and the company expressly disclaims any intent to update any forward-looking statements, whether as a result of new information, future events or otherwise.
Investor Contact:
Stephen Jasper
Gilmartin Group
(858) 525 2047
stephen@gilmartinir.com
Media Contact:
Jenna Urban
Berry & Company Public Relations
(212) 253 8881
jurban@berrypr.com
Source: Eledon Pharmaceuticals
| ELEDON PHARMACEUTICALS, INC. CONSOLIDATED BALANCE SHEETS (In thousands, except share and per share data) | ||||||||
| December 31, | ||||||||
| 2025 | 2024 | |||||||
| ASSETS | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 22,808 | $ | 20,549 | ||||
| Short-term investments | 110,528 | 119,629 | ||||||
| Prepaid expenses and other current assets | 2,352 | 3,552 | ||||||
| Total current assets | 135,688 | 143,730 | ||||||
| Operating lease right-of-use asset, net | 613 | 926 | ||||||
| In-process research and development | 32,386 | 32,386 | ||||||
| Other assets | 322 | 363 | ||||||
| Total assets | $ | 169,009 | $ | 177,405 | ||||
| LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 3,627 | $ | 5,833 | ||||
| Current operating lease liability | 358 | 314 | ||||||
| Accrued expenses and other liabilities | 14,359 | 5,430 | ||||||
| Total current liabilities | 18,344 | 11,577 | ||||||
| Deferred tax liability | 2,187 | 2,183 | ||||||
| Non-current operating lease liability | 283 | 640 | ||||||
| Warrant liabilities | 11,416 | 44,865 | ||||||
| Total liabilities | 32,230 | 59,265 | ||||||
| Commitments and contingencies | ||||||||
| Convertible preferred stock, 5,000,000 shares authorized at December 31, 2025 and 2024: | ||||||||
| Series X non-voting convertible preferred stock, | 2,151 | 2,151 | ||||||
| Series X1non-voting convertible preferred stock, | 53,543 | 53,543 | ||||||
| Stockholders’ equity: | ||||||||
| Common stock, | 75 | 60 | ||||||
| Additional paid-in capital | 482,189 | 417,946 | ||||||
| Accumulated other comprehensive income | 24 | 26 | ||||||
| Accumulated deficit | (401,203 | ) | (355,586 | ) | ||||
| Total stockholders’ equity | 81,085 | 62,446 | ||||||
| Total liabilities, convertible preferred stock and stockholders’ equity | $ | 169,009 | $ | 177,405 | ||||
| ELEDON PHARMACEUTICALS, INC. CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (In thousands, except share and per share data) | ||||||||
| Year Ended December 31, | ||||||||
| 2025 | 2024 | |||||||
| Operating expenses | ||||||||
| Research and development | $ | 66,267 | $ | 51,964 | ||||
| General and administrative | 16,984 | 18,613 | ||||||
| Total operating expenses | 83,251 | 70,577 | ||||||
| Other income, net | 4,220 | 3,924 | ||||||
| Change in fair value of warrant liabilities | 33,449 | 30,900 | ||||||
| Loss before income taxes | (45,582 | ) | (35,753 | ) | ||||
| Provision for income taxes | (35 | ) | (431 | ) | ||||
| Net loss | $ | (45,617 | ) | $ | (36,184 | ) | ||
| Other comprehensive loss: | ||||||||
| Unrealized loss on available-for-sale securities, net | (2 | ) | — | |||||
| Comprehensive loss | $ | (45,619 | ) | $ | (36,184 | ) | ||
| Basic and diluted earnings per share of common stock | $ | (0.52 | ) | $ | (0.66 | ) | ||
| Weighted-average common shares outstanding, basic and diluted | 81,836,246 | 48,543,787 | ||||||
| Basic and diluted earnings per share of Series X and Series X1non-voting convertible preferred stock | $ | (28.73 | ) | $ | (36.61 | ) | ||
| Weighted-average shares outstanding of Series X and Series X1non-voting convertible preferred stock, basic and diluted | 114,508 | 114,508 | ||||||
FAQ
What did Eledon (ELDN) announce about tegoprubart on March 19, 2026?
What were the 24‑month kidney transplant results Eledon (ELDN) reported?
What were the islet transplantation outcomes Eledon (ELDN) reported in type 1 diabetes patients?
How did Eledon's (ELDN) financials look for full year 2025?
What upcoming tegoprubart milestones did Eledon (ELDN) outline for 2026?
